Assignments for Today
- Read Walter Fitch's article on types of homology (available on HuskyCT or here)
Assignments for Wednesday
- Explore the population genetic simulations at http://www.radford.edu/~rsheehy/Gen_flash/popgen/.
- Using the same fitness and frequency for the A1 and A2 allele, explore the impact of population size on drift?
- For a larger population size (1000) explore settings that reflect balancing selection.. (w11:.9; w12:1, w22=.95)
- What happpens, if you decrease the population size?
- Using a small initial frequency of allele 1 (e.g. 0.01 with a population of 50) and a large fitness advantage for this allele, perform simulations for 20 populations.
What does this suggest for the effectiveness of natural selection? Does natural selection acting on a single advantageous allele work better in a large population?- What, if any, is the difference between a mutation and a substitution? (More than on answer is possible.)
- Read the wikipedia entry (Introduction, Use, Interpretation, Distribution, and Example sections) on the maximum likelihood ratio test (https://en.wikipedia.org/wiki/Likelihood-ratio_test) (also, I found a you tbe video that provides an introduction to the underlying idea at https://www.youtube.com/watch?v=Tn5y2i_MqQ8)
Assignments for Friday
- Take-home exam #6 is due
Take home exam#4 out of 26 (mean: 86% median: 87%) and take home exam#5 out of 27 (mean: 88% median: 87%)
Discuss globin gene evolution.
Discuss orthologs, in and out-paralogs.
PPT Slides for today