For Today:

• Does selection still play a role in human evolution? Read abstracts (or more) of articles on Natural selection in a contemporary human population, Natural and sexual selection in a monogamous historical human population, and Measuring selection in contemporary human populations.
• Read Wikipedia entry on Toxoplasma and behaviour
• Take home exam #7 is due on Friday

For Friday

• Read the wikipedia entry (Introduction, Use, Interpretation, Distribution, and Example sections) on the maximum likelihood ratio test (https://en.wikipedia.org/wiki/Likelihood-ratio_test) (also, I found a you-tube video that provides an introduction to the underlying idea at https://www.youtube.com/watch?v=Tn5y2i_MqQ8)
• Refresh you knowledge of Baysian approaches to phylogenetic inference.
  Read the following sections in the Wikipedia entry http://en.wikipedia.org/wiki/Bayesian_inference_in_phylogeny: Intro, Bayesian Inference of Phylogeny, Background and Bases, Pitfalls and controversies, MRBAYES software for Bayesian Inference of Phylogeny)

For Monday (after Thanksgiving)

• read the Wikipedia entries on PSSMs, HMMER, , and at least skim through the entry for hidden Markov models

Take home exam #7 is due

Continue slides from class 21

Goals class 22

• Know what the terms positive, negative, and neutral selection mean and what frequent synonyms for these terms are.
• Know how to infer the type of selection using synonymous and non-synonymous substitutions.
• Know that one can infer the type of selection from the rate with which a gene goes to fixation.
• Be able to discuss the terms positive and diversifying selection