;; saved by seaview on Thu Dec 5 14:51:52 2019 ;;# of segments=1 all sites ;; 1,1570 ;;# of segments=2 extein ;; 1,504 1125,1570 ;;# of segments=1 intein ;; 505,1124 ;Minichromosome maintenance protein MCM [Candidatus Heimdallarchaeota archaeon] 30Candidatus_Heimdallarchaeota_archaeon_MBS85605.1 --------------------------------------MAMSETETEKAYETFF--RD-F QDENGDFK-YVXKINQMIIEN------QRS-LVIQY-DDLIQM-DGISVESE--LADTLM -----NEPRRMINIGGRILKETIKV------EDPDFHRKNSDNK--------FFVRFD-- --GI--P--E---ETEIRDIRAMDVQNQKIYWLEGMIIRATEIKSIVDKAFFE--CEI-- DPIHSRDITF---E--------DG--YYME-P-NECD--------VC--GNR--K----- -----------MYFKP------EKSKMVDWQFITLQERPEDLPAGASPKSIPCQL-KEDI VN-----SVRPGDRVKIGGIIRFKP---KNAKK----GDLL-TYDSWVEVNFIESLT--K DDEIDELSEEEREEFIEMAREPDFFKSLVSSVAPQIHG--LREIKQAALLMLFGGV-DK- KEEG-FSTRGQPNVLLVGDPGVAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLKYVQS-IAPRGL FTSGKGSSAAGLTAAIVRD-TDT-GE-ITLEAGAMVLADRGICLIDEFDKMSENDRSAIH EAMEQQTVSVAKAGIFATLNARTGVLAAANPKYGRYEDQ-RSFSENVN---LTPAILSRF DLVFILKDKPNEEKDSILAEHILQQHIENVDETP-------------------------- --------------------------Q--NRLMDEDKLKKYIKFANNNFKPI-ISSEASE KIREFYVQMRNR-----YGGNMNNGEGS--VTITARQLEGIIRLAEAKAKASLKKEVTKE DAQFAIDLMEYSLKEI-AIDPETG-TLDIDALYSGQT---QSRRNRFSIIQSLID-DLYR ----ENNG----PFSKDELIQRAKNLENI-PET--YTNEMIDQMI-LDGVLYNPKG-DTL NKP------- ;Minichromosome maintenance protein MCM [Thermoprotei archaeon] 33Thermoprotei_archaeon_RLF15559.1 --------------------------------MEPSVSNVSLASEPTTKFIEFL--RS-F KDATGRVK-YRERIRRMILLR------QRS-LIIDF-PDLMAY-D--R---S--LATSLL -----ESPSEYIPALDRAITEVVKL------DDMEYASSVT-----------FHARLR-- --AL--P--E---TVPLRELR--AEHIGKLVMIEGILTRASPVRQLLTEAVYQ------- IGDKEGYLRI-ESP------L-EQ--VVLPGP-----------------KKK-------- -----------VKLLL------DRCKFIDWQKLTVQEKPEDLPPGQLPRSVDVIV-TDDL VD-----KARPGDRVSVIGIVKVHQ------ER----PSSPASFSIYIEANNIEVSE--S GLEGVEITPEDEKKILELAKDPDIHKKIIRSIAPSIYG--NEDIKEAIAYQLFGGV-PKV YPDG-VKVRGDIHILLIGDPGTAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLKYVAR-LAPRGI YTSGKGSTAAGLTAAVVRD-KTS-GE-FYLEAGALVLSDKGIACIDELDKMNPQDRVSMH EAMEQQTISIAKAGIVATLNARCAILAAANPRFGRYINE-RPFNENIDEKKLPPTILSRF DLIFVLKDIPDEKIDSALADHVLSLH----SGRV-------------------------- --------------------------EKIGDIIPPDLLRKYIAYAREHVHPK-LSKEAVE KIKEFYLEMRSK-----A----KGGLSP--IPITPRQLESLIRLTEARARMALREIATAE DAEAAIRLMKVCLSKV-GYDEETG-KIDIDIIMVGRP---RSHQERLATIMDIIK-KLEE ----EYG---GEPVSIEEIYREAELR-DI-PKE--FVDKSLKYLM-EEGEIYEPRP-GYV KRTRS----- ;hypothetical protein AM324_10500 [Candidatus Thorarchaeota archaeon SMTZ1-83] 34Candidatus_Thorarchaeota_archaeon_SMTZ1-83_KXH69699.1 --------------------------------------MTLEMETEQERFEEFI--RT-F KDEQGSTV-YWSRVQQ-MSIDD-----ESS-LVVDF-QDLIGF-D--NV-----FMAFAT -----EDPQTFLRMAHNALVSILKI------EDPEYVGTIGHDG--------LQVRII-- --NY--S--E---NVPLRHIR--SRHIGKLIRISGIMMRASEVKPLLVNATFQ--CRV-- CMA---EIPQ---E--Q---E-EG--RYTE-P-PLCS--------TC--GKK--T-P--- -----------MKLLL------AKSRFIDWQKVRIQESPEELPPGQMPRSVDVVL-KGDI VD-----ISRPGDMVKVTGLLQTTP--DFSRRG----GKLA-TFNVFIEANGVEIAE--K EYEQLEISEEDEKAINELSKNPYIHEKIYRSIAPAIQG--HDEIKQSISLLLFGGV-DKT LPDG-TRLRGRSNILMVGDPGTGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQILKFVSG-LASRAL YTSGKGTTAAGLTAAVIHD-ADS-GA-MTLEAGALVLADQGIACIDEFDKMDPNDRTAIH EAMEQHTVSIAKAGIVATLNARTSILAAANPTLGRYETS-WTPQENIK---LPFTILSRF DLVWVMIDTPNEERDKELARFILDMH----QGKP-------------------------- -----------------------TKTTDETAPIPPGLLKKYIGYANRNVIPQ-LSPEAAE AIEDFYVGLRKR-----A----EGGAAP--VPITARQLESLVRLAEARAKMALRKNVTKE DGQAAVALMTASLQGV-ALDVETG-ELDIDRLVSQES---ASQRSARTAIINTLK-EMET ----DGS---E---SEVELLQRLEVK-GL-PRE--RAEAIIARLV-EEGAVYSPKGEGTI RLPPKS---- ;Minichromosome maintenance protein MCM, partial [Thermoprotei archaeon] 35Thermoprotei_archaeon_RLF03676.1 -----------------------------------------------------L--NR-- ---------------------------MRS-LVIEF-DDIIAF-D--S---D--MASFII -----EKPRLAIAEASKAIKDVMYI------ENRDYAEEVEY----------FIARFR-- --NL--P--E---QIPLRGIR--AIHINKLISLEGIVTRVTPVKQLLTHAVFR--CKS-- CGE---TIIV---P------QKGR--GLEY-P-EACP--------VCSTNGKKRSQG--- -----------FEFIP------EESKYIDWQKLVLQEKPEELPPGQLPRSIEVVV-TEDL VD-----VARPGDRAIITGILSVHS--EKSLRK----DVQP-IFRTYLEANYVDVVS--K EAYDVQITPEDEEKILKLAQLPDIRERIINSIAPSIHG--YKDIKKAIACLLFGGE-PKI FPDG-VRVRGDIHILLVGDPGTAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLRYVSY-IAPRGI YTTGKGSTAAGLTAAVVRE-RST-GD-FYLEAGALVLADGGVACIDEFDKMDPRDRVSIH EAMEQQTISIAKAGIVATLNARASILAAANPAFGRYLRQ-RTIAENID---LPVTILSRF DLIFVITDIPDAENDESLARHVVELH----RGIT-------------------------- -------------------------SRAFENIINPMFLKKYIAYARKYIHPK-LSQEAED KIVRFYIDMRSR-----S----QDPNSP--IAITPRQLEALIRLAEAHAKMALSNTVTAE DAEAAIALMLKFLQGV-GLDVETK-AIDIDIILTGKP---MSQREKFVKLMDILK-EMDR ----EYKE--K-PIKLEEFIKRAEEE-GL-DRA--FIEKAIMHLK-REGEIYEPRP-GYI KKT------- ;Minichromosome maintenance protein MCM [Thermofilum sp. ex4484_79] 36Thermofilum_sp._ex4484_79_OYT31763.1 ---------------------------------MYMAKMEEISLDPRAKFAFFF--KT-F KDKFGEYK-YRERISSLSLNR------MRS-LVIEF-DDIIAF-D--S---D--MASFII -----EKPRLAIAEASKAIKDVMYI------ENRDYAEEVEY----------FIARFR-- --NL--P--E---QIPLRGIR--AIHINKLISLEGIVTRVTPVKQLLTHAVFR--CKS-- CGE---TIIV---P------QKGR--GLEY-P-EACP--------VCSTNGKKRSQG--- -----------FEFIP------EESKYIDWQKLVLQEKPEELPPGQLPRSIEVVV-TEDL VD-----VARPGDRAIITGILSVHS--EKSLRK----DVQP-IFRTYLEANYVDVVS--K EAYDVQITPEDEEKILKLAQLPDIRERIINSIAPSIHG--YKDIKKAIACLLFGGE-PKI FPDG-VRVRGDIHILLVGDPGTAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLRYVSY-IAPRGI YTTGKGSTAAGLTAAVVRE-RST-GD-FYLEAGALVLADGGVACIDEFDKMDPRDRVSIH EAMEQQTISIAKAGIVATLNARASILAAANPAFGRYLRQ-RTIAENID---LPVTILSRF DLIFVITDIPDAENDESLARHVVELH----RGIT-------------------------- -------------------------SRAFENIINPMFLKKYIAYARKYIHPK-LSQEAED KIVRFYIDMRSR-----S----QDPNSP--IAITPRQLEALIRLAEAHAKMALSNTVTAE DAEAAIALMLKFLQGV-GLDVETK-AIDIDIILTGKP---MSQREKFVKLMDILK-EMDR ----EYKE--K-PIKLEEFIKRAEEE-GL-DRA--FIEKAIMHLK-REGEIYEPRP-GYI KKT------- ;Minichromosome maintenance protein MCM [Thermoprotei archaeon] 37Thermoprotei_archaeon_RLF24408.1 -------------------------------MEVSEPKEYAVLSDPRLKFTEFY--RT-F ETEDGRLK-YRERIRR-MVLLR-----QRS-LLIDF-SDLLAF-D--K---D--LAMELL -----RNPAPYIEAASKAISTIVSV------YDEEYARST---E--------FFARFR-- --NL--P--E---CTPIRELK--AAHIGHLVMIEGILTRATPVKQQIVEAVFE--CE--- CGE---RITV---R--QD----SY--VLKQ-P-GRCP---NP---AC--GRR--S----- -------S---FRLLI------EESKFRDWQRITVQERPEELPPGQLPRSIDVVV-TDDL VD-----KARPGDRVVITGILRVQQ--DRSSRG----AKLS-TFSVYVEANCIDVSR--A ELGEVVVSPEDERVILELAKQPDIHEKIVRSIAPSIYG--YEHIKEAIAYQLFGGV-PKV YPDG-VRVRGDIHILLVGDPGTGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLKYVAK-IAPRGL YTTGKGSSAAGLTATVLRD-KTT-GE-FYLEAGALVLCDKGIACIDEIDKMDTKDRVSIH EAMEQQTVSIAKAGIVATLNARCAILAAANPKYGRYIFE-RSFNENIDERKLPPTILSRF DLIFIITDRPEASRDEALARHVLELH----GGTH-------------------------- --------------------------IAMRDIIPPDLLRKYIAYAREKVHPK-LSTEAME EIRKFYLEMRSK-----A----QGVHSP--VPITPRQLESLIRLAEARAKMALRDVVTAE DARAAIRIMKLCLSSV-GYDEETG-AIDIDIIMVGKP---RSQQEKMARLMDIIR-ELEE ----AHDG--K-PVPLDEIYDEAERE-GL-DRA--FVDKALRHMK-DEGLIYEPRP-GYV KRT------- ;hypothetical protein DRN50_06970 [Thermococci archaeon] 40Thermococci_archaeon_RLF93599.1 -------------------------------------MMEIEYEDILNRFRDFF--LA-Y PD-VSNPK-YKTYIDEMKTTE------KKS-LDIDC-DDILDY-D--P---E--LYEAIV -----ERPVEVIPIAEDALKSILLG------------ED-------------VFVRFY-- --NA-----K-SEEIEIRDLR--SIHVNKFIQVMGIVGRSSEVKPEIVEAVFQ--CQR-- CGHIQIVEQI------------EE--FFKK-P-GICENP------AC--GRN--G-P--- -----------FKLLE------DQSKFRDWQVLKIQERPEKLRGGRMPRRINLII-RDDL VE-----LAKAGDRVTVTGILKTVQ---ESTFK----GKKT-TFRKYIDVNSIRIED--Q DVEEIKIAKEEEEKIKKLAQDPFIIEKIASCIAPSVYG--YPDIKEAIAMQLFSGV-LKE LPDG-TRLRGDPNILLVGDPGVAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLQYASK-IAPRGL YTSGKGTSAAGLTAAVVHD-ETT-GG-WALEAGALVIADGGIACIDEIDKMSKDDRSSIH EAMEQQTISIAKAGIVATLNARSAILAASNPKYGRFDRF-KSFAEQID---LPPTLISRF DLVFIITDVPDEERDKATAKHILDVH--RNAGEV-------------------------- ----------------------------ITPPIDLELLEKYILYAKINKFPV-LTKQASR KMHNFYVQLRKI-----A----QDRDAP--VPITARQLEALIRLGEARAKMRLSDKVEAE DAEAVIKLFKNTLFKV-GIDPETG-KLDIDVIMTGKP---KSQRDRLIHLMDIIS-ELDK -------G--D-GISLEDIIQEAERE-GM-DKN--FVRRAIEEFK-QKGDLYEPTP-NKF KVLR------ ;hypothetical protein DRN45_02865 [Thermococci archaeon] 41Thermococci_archaeon_RLF94697.1 -------------------------------------MMEIEYEDILNRFRDFF--LA-Y PD-VSNPK-YKTYIDEMKTTE------KKS-LDIDC-DDILDY-D--P---E--LYEAIV -----ERPVDVIPIAEDALKSILLG------------ED-------------VFVRFY-- --NA-----K-SEEIEIRDLR--SIHVNKFIQVMGIVGRSSEVKPEIVEAVFQ--CQR-- CGHIQIVEQI------------EE--FFKK-P-GICENP------AC--GRN--G-P--- -----------FKLLE------DQSKFRDWQVLKIQERPEKLRGGRMPRRINLII-RDDL VE-----LAKAGDRVTVTGILKTVQ---ESTFK----GKKT-TFRKYIDVNSIRIED--Q DVEEIKIAKEEEEKIKKLAQDPFIIEKIASCIAPSVYG--YPDIKEAIAMQLFSGV-LKE LPDG-TRLRGDPNILLVGDPGVAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLQYASR-IAPRGL YTSGKGTSAAGLTAAVVHD-ETT-GG-WALEAGALVIADGGIACIDEIDKMSKDDRSSIH EAMEQQTISIAKAGIVATLNARSAILAASNPKYGRFDRF-KSFAEQID---LPPTLISRF DLVFIITDVPDEERDKATAKHILDVH--RNAGEV-------------------------- ----------------------------ITPPIDLELLEKYILYAKINKFPV-LTKQASR KMHNFYVQLRKI-----A----QDRDAP--VPITARQLEALIRLGEARAKMRLSDKVEAE DAEAVIKLFKNTLFKV-GIDPETG-KLDIDVIMTGKP---KSQRDRLIHLMDIIS-ELDK ----GDGI------SLEDIIQEAERE-GM-DKN--FVRRAIEEFK-QKGDLYEPTP-NKF KVLR------ ;minichromosome maintenance protein MCM [Candidatus Heimdallarchaeota archaeon] 42Candidatus_Heimdallarchaeota_archaeon_TET30073.1 --------------------------------------MVSDTTDPVAAFNEFI--RE-F RDENGNYI-YREQIQQ-MTVEG-----EIS-LKVDF-TDVIKF-N--P---E--LARRSI -----DEPKEFLEAGNRAVTEVVEI------EDSDYAFTTR--E--------FFIRFF-- --NM--S--E-SEIIPLRGIR--TEHVGKLVMLYGITTRATVVKPLLIEGFFQ--CQN-- CQE---IMIL---P--QE----EG--RYNP-P-HQCQ---NP---GC--GRA--G----- -------P---FKLLT------EESKFVDWQKVTIQERPENLPPGQMPRSVSVLL-KHDM VD-----KVRPGDRISVIGVLQSIP---DFSKK--TPGKLA-TFHINMNANYVIPEE--Q DLEALEISEEEEQIILDLAKDPWIHTKIVDSLAPSIYG--YRDIKESLALLLFGGI-PKE LPDG-LKIRGESNILLIGDPGTAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQILRYIAT-LAPRAL YTSGKGSSAAGLTVAVLRD-QDT-GE-FTLEAGALVLSDRGVCCIDELDKMRKEDRSSIH EAMEQRTVSVAKAGIVATLNARCSILAAANPKLGRYIPS-RSAAENIN---LPVTILSRF DLIWIVRDEPEADVDKVKAQHILRLH---TAGVT-------------------------- ---------------------------EKEPPISKEILKKYISYAKLNSTPR-LSDEAAK RLEEFYLEMRKA-----G----EASDSP--IAITPRQLESLIRLTESHARMALRSEASIE DAEAAIRLLSVSLRQV-GIDPETG-KLDIDVVMVGTS---SSTRSKIETLMDLIA-EMEL ----ESK---GQAVPLDRIIEKAHDF-GM-TKD--FIERNIERMR-QDGMLFQPKA-GFI KRT------- ;minichromosome maintenance protein MCM [Vulcanisaeta thermophila] 43Vulcanisaeta_thermophila_WP_069807595.1 --------------------------------MTESEEKVVNVDDAIQGFRDFI--EG-D EK-------YVDEINNMIIQR------RKS-LVIDF-HDLLLR-N--K---D--LADMLI -----ERPQLAIQAASEAVRQAVTE------RDPELAKSIK--N--------FYARFK-- --RL--P--E---TVPIRKLR--SEVLGKLIMVEGIVTRQTPPKHYLKKTVFR--CSE-- CGF---ELEI---P--Q---P-TT--SFVQPP-RKCP--------KC--GAT--NS---- -----------FVLVE------ERSELIDWQKIIVQEKPEELPPGQLPRNIEAIL-LDDL VD-----TVKPGDRVYLVGIMNLDI---AQLRK----NKPP-ILSSFMEVNYVEGQQ--R EFVEIEITPEDERRILEIARSPNVRERIIKSIAPSIYG--MENIKEAIACLLFGGV-PKV YPDG-IRVRGDIHILLVGDPGMAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------TQLLRFVAK-IAPRAV YTTGKGSSAAGLTAAVVRE-KDT-GE-FYLEAGALVLADTGVAVIDELDKMDAKDRVAIH EALEQQTVSIAKAGIVATLNARASVLAAANPAFGRYLPN-RTVAENVD---LPVTLLSRF DLIFIIRDEPSMERDRAIAEHIVTLH----AGEVP------------------------- --------------------------ESFSDIIPPELLRKYIAYARKHIKPV-LTPEARE RIVQFYVQMRNK-----S----REPGSP--IAITARQLEALIRLAEAEARMRLSPVVEAE DADKAIRLFMSYLSSV-GIDVESG-KIDIDVIMTGKP---RSSQERLALVMDILS-RLEE ----ANGG--K-PVRVEDLYKEAEGA-GL-DRQ--FVDKALNMLV-KSGDVYMPRP-GYV KRVVV----- ;Minichromosome maintenance protein MCM [Candidatus Verstraetearchaeota archaeon] 45Candidatus_Verstraetearchaeota_archaeon_RLE57022.1 ------------------------------------MTLEISELDPREKFANFY--KS-F KTSEGEYK-YRRLLSQ-MAITG-----QRS-LHIDF-DDLMQY-D--H---E--LAERLI -----EKPFRYIEAASNAVGDVMRI------INLNYAMKVKR----------FKARFR-- --KL--P--E---VTPLRKIR--AEHLGKLIMIEGILTRSSSVKQQLIRGIFE--CQN-- CGA---AIAV------EAKRR-EE--RVVQ-P-KICP--------NC--RKN--G-P--- -----------FKLIL------EESEFIDWQRLTIQEKPEELPPGQLPRSIEAIA-REDL VD-----VARPGDRVVVVGILKPIR---EYSPR----GSLS-TFRPEIEINSIDVSE--K GLEEIEISPEDEEAIKELAKDPLIHEKIIRSIAPSIYG--YREIKEGIAYLLFGGV-PKT LPDG-VRIRGDINILLVGDPGTAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLQYVSR-IAPRGI YTSGKGSTAAGLTAAVVRD-KLT-GD-WYLEAGALVLADGGVACVDEIDKMRNEDRVAMH EVMEQQTVSIAKAGIVATLNARTAILAAANPTLGRFIEQ-KPITENVN---LPVTILSRF DLIFKIRDIPDETIDEKMSEHILRLH--QLRGYT-------------------------- ----------------------------GPTPIPPDLLKKYISYARKNVQPR-ISQEAFE RIKKYYVEMRKK----------GKEVGS--IPITPRQLEALVRMSEARAKMALREEATKE DAEAAIRLMSYVLETT-AYDRETQ-SIDIDVLMTGKS---RSQREKLGKLMDIIREKIRE ----ISG-----PVKREEIVEAAKNA-GL-EES--FIELALEKLS-KEGVIFEPRQ-GYI MLT------- ;minichromosome maintenance protein MCM [Methanothermobacter wolfeii] 47Methanothermobacter_wolfeii_WP_145924506.1 -----------------------------------MMKTVDKSKTALTKFEEFF--ST-- -K-------YKDKVFEAIEKYPT----ERS-IHVDY-LDLEMF-D--P---D--LADLLI -----EKPDDVIRAAQQAIRNIDPL-----------RKNAE-----------LNIKFM-- --GI--S--N---IIPLRELR--SKFIGKFVAVDGIVRKTDEIRPRIVKAVFE--CRG-- CMR---LHEV--TQ------S-TN--MLTE-P-SMCS--------EC--GGR--S----- -----------FRLLQ------DESEFLDTQTLKLQEPLENLSGGEQPRQITVVL-EDDL VD-----TLTPGDIVRVTGTLRTVR-------D----ERTK-RFKNFIYGNYAEFLE--Q EFEELQITEEDEEKIKELASDPNIYEKIIRSTAPSIHG--YREVKEAIALQLFGGS-GKE LDDK-TRLRGDIHILIVGDPGIGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQMLKYVSK-LAPRGI YTSGKGTSGVGLTAAAVRD-EFG-G--WSLEAGALVLGDKGNVCVDELDKMREEDRSAIH EALEQQTISIAKAGIMATLNSRCSVLAAANPKFGRFDSY-KSIAEQID---LPSTILSRF DLIFVVEDKPDEDKDRALARHILKTH----KEDQ-------------------------- ----------------------------MPFEIDPELLRKYIAYARKNVRPV-LTDEAMQ VLEDFYVSMRAS-----A----ADEDSP--VPITARQLEAIIRLSEASAKIKLKEHVEAE DARKAIKLSQACLKQV-GYDPETG-KIDIDKVEGRTP---KSERDKFRLIIELIR-EFED ----EYG---G-KAPTNILISEMMDRYNV-SEE--KVEEVIRILK-DKGVIFEPSR-GYL KIV------- ;Minichromosome maintenance protein MCM [Candidatus Verstraetearchaeota archaeon] 48Candidatus_Verstraetearchaeota_archaeon_RLE50187.1 ----------------------------------MGLELTPELLDPREKFVNFY--KT-F QAPDGSFK-YRERIRQ-MASLG-----KRS-LVIDF-EDLLVY-D--H---E--LATSLI -----EEPAKVIEAASKAILDVMRV------EDMEYANKVKT----------FNARFR-- --RL--T--E---ATSLRAIR--VENLNKLIMVEGIITRATAVKHLLVNAVFR--CER-- CGE---EIPQ---P--Q---P-GG--PLVT-P-AQCTNPG------C--QRK--G-P--- -----------FRLIP------ERSTFMDWQKLTLQERPEDLPPGQLPRSIDVIV-RDDL VD-----AARPGDRVSIVGILKPQQ--DVTARG----SKLT-TFSSYIEANYIDVAE--R GAEEVEITPEDEQKIKELAKDPLIHSRIVRSIAPSIHG--LEEVKEAIAYLLFGGT-PKV MPDG-VRIRGDINILLVGDPGTAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLQYVAK-IAPRGI YTSGRGSTAAGLTATVVRD-KTT-GE-FVLEAGALVLADGGVACIDEIDKMRQEDRVAIH EAMEQQTVSIAKAGIVAQLNARASILAAANPALGRYVPH-KTPAENID---LPVTILSRF DLIFPIMDRPDEDRDRALSEHILRLH----QHQS-------------------------- --------------------------PAHEGIIPPDLLKKYISYARRYVTPH-LTPQAAK RIQDFYLEMRMK-----S----EGPDSP--VPISPRQLEALIRLSEARAKIALRSEVLEE DADAAIRLMKYFLVQV-GMDKSTG-RFDIDTILVGRP---KSQSDKIAKLLELLI-EMER ----ENEG--G-PVRKDQFIER-AELLGL-ERF--FVEKVLNQWR-NEGVIYEPRS-GYI KKA------- ;minichromosome maintenance protein MCM [Vulcanisaeta sp. EB80] 50Vulcanisaeta_sp._EB80_WP_081227344.1 ----------------------------------MTEPMEVSLDSLIQGLRDFI--ES-S DR-------YVDEINNMIIQR------KKS-LVIDF-HDLLIS-N--K---D--LADMLL -----ERPQLIMQAGSEAVRQAITE------RDPELAKSVR--N--------FYMRFR-- --RL--P--E---SLPIRKLR--SEVLGRLIMVEGIITRQTPPRHYLRKSVFR--CSQ-- CGY---EVEI---P--Q---P-TT--GFVQPP-KRCP--------KC--GAI--NS---- -----------MVFVE------ERSEFIDWQKIIVQEKPEELPPGQLPRSIEAIL-LDDL VD-----TVKPGDRVYLVGVMNLDL---ADLRK----GKPP-VVSSFMDVNYVESQQ--R ELVEIEITPEDEKRILDLAKMPDVRERIIRSIAPSIYG--MEDIKEAIACLLFGGV-PKV YPDG-IRVRGDIHILLVGDPGMAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------TQLLRFVTK-IAPRAV YTTGKGSSAAGLTAAVVRE-KDT-GE-FYLEAGALVLADTGVAVIDEIDKMDAKDRVAIH EALEQQTVSIAKAGIVATLNARCSVLAAANPAFGRYLPN-RTVAENVD---LPVTLLSRF DLIFIIRDEPNLDRDKAIAEHITTLH----AGEV-------------------------- -------------------------PEGFTEIISPDLLRKYIAYARKHVKPV-LTPEARE RIVQFYVQMRAK-----S----REPDSP--IAITARQLEALIRLAEAEAKMRLSPVVEAE DADRAIRLFMKYLSSV-GIDIESG-KIDIDIIMTGKP---KSAQERLALVMNILA-QLED ----ANGG--K-PVRIEDLYREAESA-GL-DRQ--AVDKAINMLL-KSGDVYTPRP-GYI KLIRL----- ;minichromosome maintenance protein MCM [Thermococcus celer] 53Thermococcus_celer_WP_088862216.1 ----------------------------------------MDREEMIERFARFL--RE-Y VDDDGNEV-YLNRLKDLLTVIP-----KRS-LAVDW-THLNSF-D--P---E--LAEELL -----ENPEESIAAAEDAIQIVLRE------PPLLKEEEFR-----------VHARFH-- --NL--P--R---TLLVKELG--SEHINRLIQVEGIITRVSEVKPFVQKAVYV--CKD-- CGN--EMVRL-QKP--------YG--NLVK-P-AKCD--------AC--GSR--N----- -----------IDLDV------EKSRFINFQSFRLQDRPESLKGGQMPRFVDAIL-LDDL VD-----TALPGDRVLVTGILRVIL-----EGK----DKRP-IFKKVLEVNHIEQLS--K EIEELEISPEDEQRIRELARRKDIVDAIVDSIAPAIWG--HKTVKKGIALALFGGV-QRT LPDG-TKLRGESHVLLVGDPGVAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLRYVSN-LAPRAI YTSGKSSSAAGLTAAAVRD-EFT-GS-WVLEAGVLVLADGGFACIDEFDKMSERDRSAIH EALEQQTISISKAGITATLNARTTVIAAANPKFGRFNRH-KSLPEQLD---LPPTLLSRF DLIFLLLDEPDEKVDSSIAEHILKVR----RGEA-------------------------- --------------------------EAVTPKIPYDLLKKYIAYARKNVHPV-LSREAME EIKRYYVRMRKG-FKRPGE---DEGVQA--IPITARQLEALIRLSEAHARMRLSETVTRE DAKAAMAIIEDMIRKI-AVD-EEG-TLDVSILEVGKS---SRKINKIDKMIDIIK-NLES ----EGE---F-GAPEDEIIEAAKGA-GLGSEG--EIKKLLNDLK-RDARIYEPRA-GFY RVL------- ;AAA family ATPase [Methanobacterium sp.] 54Methanobacterium_sp._RJS48138.1 -----------------------------------MTHATDKTKTSLAKFEEFF--ST-- -K-------YKDNVFEALEKYPD----QRS-VVIDY-LDLEMF-D--P---D--LADLLI -----EKPEEVIRASQKAIKNIDPL-----------RKNAD-----------LNIRLE-- --NV--T--N---NIPLRFLR--SKFIGKFLSVDGIVRKTDEIRPRIITAMFE--CRG-- CMR---LHEV--SQ------S-SN--MIAE-P-SLCS--------DC--GGR--S----- -----------FRLLQ------EESEFMDTQTVKVQEPLENLSGGEQPRQILVVL-EDDL VD-----SLTPGDIVRITGTLRTVR-------D----EKTR-RFKNYIYGNFIEHLE--Q EFEELLLSPEDEENIKELSRDEHIYEKIIKSTAPSIHG--YRDVKEAIALQLFGGS-GKE LEDK-TRLRGDIHILIVGDPGIGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQMLKYVSK-LAPRGI YTSGKGTSGVGLTAAAVRD-ELG-G--WSLEAGALVLGDRGNVCVDELDKMREEDRSAIH EALEQQTISIAKAGIMATLNSRCSVLAAANPKFGRFDSF-KSLAEQIE---LPSTILSRF DLIFVVEDKPDMEKDRALARHILSIH----KEDS-------------------------- ----------------------------MPYEIDPELLRKYIAYARRHSHPV-LSEGAMD VLEEFYVSMRNS-----A----SDDESP--VPITARQLEAIIRLSEASAKIKLKSVVDAE DAKKAIKLQQACLKQV-GYDPETG-KIDIDKVEGRPP---KSERDKFRILVEVIK-ELEE ----EYN---G-KAPTNILISEMGDRYTV-SPE--KVEELVRVLK-HKGVIFEPTR-GYL KVV------- ;Minichromosome maintenance protein MCM [Thermoprotei archaeon] 55Thermoprotei_archaeon_RLE62281.1 -----------------------------------MTEITEATLDPRQKFIDFF--KT-F QASTGEYK-YRDRIGRMAAAN------SIS-LVIDF-EDILAI-D--A---E--LASLIV -----ERPRYLIPEASKAILDVMKV------ENPEYAASVDH----------FIARFK-- --GL--P--E---IVPLRKVR--AVHINRLIALDGIVTRISPVKQQLIEAVFQ--CTE-- CGE---EVIV---P--Q---T-GK--GVTA-P-KICP--------VC--SREEGKKRST- -----------FDLKI------EKCKFIDWQKMILQERPDELPPGQLPRSIEIIV-TEDL VD-----VARPGDRAIITGILSVEP--ERSSNR----EGPP-IFKTFVEANYIDVMS--K ETYDVEITVEDEKRILELAKLPDIRDRIISSIAPSIHG--YREIKEAVACLLFGGE-PKI FPDG-VRTRGDIHVLLVGDPGTGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQILRYVAT-IAPRAV YTTGKGSTAAGLTAAVVRE-RRT-GE-FYLEAGALVLTDGGVACIDEFDKMDPRDRVSIH EAMEQQTISIAKAGIVATLNARASVLAAANPAFGRYIRQ-RTIAENID---LPVTILSRF DLIFVITDVPNAESDRSLAEHVVGLH----SGDY-------------------------- -------------------------SEKFRNLIPPELLKKYVAYARRYIHPR-LSEEAKQ KIIDFYTEMRAR-----G----EDPNSP--IAITPRQLEALIRLAEAHAKMALKTIVTEE DAEAAIRLMMCFLQGV-GLDTETK-SIDIDIVMTGKP---MSQREKLIKLIDILR-ELEK ----ESS---NGMVKVQELLDRAASQ-GL-DKE--FVEKALQHLR-KEGEIFEPRP-GYV KKT------- ;Minichromosome maintenance protein MCM [Thermoprotei archaeon] 57Thermoprotei_archaeon_RLE84755.1 ---------------------------MLQVNSMVESTIIIEKFDPRERFIEFL--KT-F ED-ASGLK-YRKLISQMVLEK------SVS-LEIDF-EDLLSF-D--E---E--LANFLL -----EHPAETLEEAGKAVKEVMKI------ENANYAKLVD--R--------FFARIK-- --NL--P--E-NFHVPLRKLR--AIHINKFISVEGIVTRMTPVKQQLTVALFK--CRE-- CGE---EIEV---E--Q---V-GR--GLSA-P-SSCPV--------C--QAE--G-R--- -------KRSSFDLIL------ERSKFIDWQKFILQEKPEELPPGQLPRSLEVIL-KDDL VD-----AVRPGDRVTVTGILAVVED--KAVRK----DQPP-IFYTYMNANHVEVST--K ENIDIEITPEDEVKILELAKRPDIRDLIINSLAPSIYG--YREIKKAIALLLFGGV-PKV YPDG-VRVRGDIHVLLVGDPGTAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLRYVST-IAPRGI YTTGKGSTAAGLTAAVIRE-KRT-GD-FYLEAGALVLADGGIACIDEFDKMDPRDRVSIH EAMEQQTISIAKAGIVATLNARASILAAANPAFGRYIPE-RSVVENID---LPVTILSRF DLIFVITDRPNKDEDRHLAEYVLDFH----RFKY-------------------------- -------------------------MDVFENTIHPDLLKKYIAYARQHIRPR-LSEEAKK KLVDFYIDMRAR-----S----EDPTSP--IAITPRQLEALVRLAEAHAKMALSSVVTEK DAEAAIELMLFMLRKV-GMDVKTQ-AFDIDIIMTGQP---KSKRDRILKIIDLIT-EMIK ----ENNN--E-PIRKEDVIQRATTL-GF-ERS--FVEKVIERLQ-DSGELIEPKP-GYI LKTIM----- ;Minichromosome maintenance protein MCM [Vulcanisaeta sp. JCHS_4] 58Vulcanisaeta_sp._JCHS_4_KUO82090.1 ----------------------------------MTEPMEVSLDSLIQGLRDFI--ES-S DR-------YVDEINN-MIIQR-----KKS-LVIDF-HDLLIS-N--K---D--LADMLL -----ERPQLIMQAGSEAVRQAITE------RDPELAKSVR--N--------FYMRFR-- --RL--P--E---SLPIRKLR--SEVLGRLIMVEGIITRQTPPRHYLRKSVFR--CSQ-- CGY---EVEI---P--Q---P-TT--GFVQPP-KRCPK--------C--GAI--N-S--- -----------MVFVE------ERSEFIDWQKIIVQEKPEELPPGQLPRSIEAIL-LDDL VD-----TVKPGDRVYLVGVMNLDL---ADLRK----GKPP-VVSSFMDVNYVESQQ--R ELVEIEITPEDEKKILDLAKMPDVRERIIRSIAPSIYG--MEDIKEAIACLLFGGV-PKV YPDG-IRVRGDIHILLVGDPGMAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------TQLLRFVTK-IAPRAV YTTGKGSSAAGLTAAVVRE-KDT-GE-FYLEAGALVLADTGVAVIDEIDKMDAKDRVAIH EALEQQTVSIAKAGIVATLNARCSVLAAANPAFGRYLPN-RTVAENVD---LPVTLLSRF DLIFIIRDEPNLDRDKAIAEHITTLH----AGEV-------------------------- -------------------------PEGFTEIISPDLLRKYIAYARKHVKPV-LTPEARE RIVQFYVQMRAK-----S----REPDSP--IAITARQLEALIRLAETEAKMRLSPVVEAE DADRAIRLFMKYLSSV-GIDIESG-KIDIDIIMTGKP---KSAQERLALVMNILA-QLED ----ANGG--K-PVRIEDLYREAESA-GL-DRQ--AVDKAINMLL-KSGDVYTPRP-GYI KLIRL----- ;minichromosome maintenance protein MCM [Methanobrevibacter gottschalkii] 59Methanobrevibacter_gottschalkii_WP_091699389.1 ------------------------------------MNSTTKSQTSIAKFEEFF--AT-- -S-------YKDDVFKILEQYPD----ERS-LNVDY-RTLEIF-D--P---D--LADLLI -----DKPEEVIDAAKIAIKNIDPL--------------VKDAD--------INIRFE-- --HL--S--N---IIPLKTLL--SKYIGTFVAADGIVRKTDEIRPRIETGVFE--CRG-- CMR---LHEV---E--QS--S-AN--RIIE-P-SLCS--------EC--GGR--S----- -----------FRLLQ------EESKYVDTQTARMQEPLENLSGGTEPKQMLMIL-EDDL VD-----KLNPGDKVRITGTLKTFR------EE-----RSG-KFKNYIYVNHIEPLE--Q EFEELQLSEEDEEQIIELSKDPNIYDKIIKSTAPSIRG--YRDVKEAIALQLFGGA-AKQ LEDE-TKLRGDIHILIVGDPGIGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQILKYVSR-LAPRSI YTSGKGTTGAGLTAAAVRD-ELG-G--WSLEAGALVLGDQGNVCVDELDKMRSEDRSALH EALEQQTVSIAKAGIMATLNSRCSVLAAANPKFGRFDRY-KVLAEQID---LPAPIISRF DLIFVIEDKPSKERDSKLAEHILKTH----QFNT-------------------------- ----------------------------VDYEIEPELLRKYIAYARKNVNPR-LTEEANE VLKEFYVSTRNS-----N----PEEQGA--VPITARQLEAIIRLSEASAKIKLKETVDKE DAEKAVRLQLACLKEV-GVDPETG-ELDADIVSGGTP---KSDRDKIQRVTEEIK-QLEE ----EYA---G-QAPLNVLISNMSDKYGV-SED--KTEQIVKNLV-QKGVIYQPVN-GYF KRVV------ ;Minichromosome maintenance protein MCM [Vulcanisaeta sp. SCGC AB-777_J10] 60Vulcanisaeta_sp._SCGC_AB-777_J10_PVU73010.1 ----------------------------------MTEPMEVSLDSLIQGLRDFI--ES-S DR-------YVDEINNMIIQR------KKS-LVIDF-HDLLIS-N--K---D--LADMLL -----ERPQLIMQAGSEAVRQAITE------RDPELAKSVR--N--------FYMRFR-- --RL--P--E---SLPIRKLR--SEVLGRLIMVEGIITRQTPPRHYLRKSVFR--CSQ-- CGY---EVEI---P--Q---P-TT--GFVQPP-KRCP--------KC--GAI--NS---- -----------MVFVE------ERSEFIDWQKIIVQEKPEELPPGQLPRSIEAIL-LDDL VD-----TVKPGDRVYLVGVMNLDL---ADLRK----GKPP-VVSSFMDVNYVESQQ--R ELVEIEITPEDEKRILDLAKMPDVRERIIRSIAPSIYG--MEDIKEAIACLLFGGV-PKV YPDG-IRVRGDIHILLVGDPGMAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------TQLLRFVTK-IAPRAV YTTGKGSSAAGLTAAVVRE-KDT-GE-FYLEAGALVLADTGVAVIDEIDKMDAKDRVAIH EALEQQTVSIAKAGIVATLNARCSVLAAANPAFGRYLPN-RTVAENVD---LPVTLLSRF DLIFIIRDEPNLDRDKAIAEHITTLH----AGEVP------------------------- --------------------------EGFTEIISPDLLRKYIAYARKHVKPV-LTPEARE RIVQFYVQMRAK-----S----REPDSP--IAITARQLEALIRLAEAEAKMRLSPVVEAE DADRAIRLFMKYLSSV-GIDIESG-KIDIDIIMTGKP---KSAQERLALVMNILA-QLED ----ANGG--K-PVRIEDLYREAESA-GL-DRQ--AVDKAINMLL-KSGDVYTPRP-GYI KRVIV----- ;MULTISPECIES: minichromosome maintenance protein MCM [Methanobrevibacter] 61Methanobrevibacter_WP_069573767.1 ------------------------------------MNSTTKSQTSIAKFEEFF-ATS-- ---------YKDDVFKILEQYPD----ERS-LNVDY-RALEIF-D--P---D--LADLLI -----DKPEEVIDAAKIAIKNIDPL-----------VKDAD-----------INIRFE-- --HL--S--N---IIPLKTLL--SKYIGTFVAADGIVRKTDEIRPRIETGVFE--CRG-- CMR---LHEV-EQS------S-AN--RIIE-P-SLCS--------EC--GGR--S----- -----------FRLLQ------EESKYVDTQTARMQEPLENLSGGTEPKQMLMIL-EDDL VD-----KLNPGDKVRITGTLKTFR---EERSG---------KFKNYIYVNHIEPLE--Q EFEELQLSEEDEEQIIELSKDPNIYDKIIKSTAPSIRG--YRDVKEAIALQLFGGA-AKQ LEDE-TKLRGDIHILIVGDPGIGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQILKYVSR-LAPRSI YTSGKGTTGAGLTAAAVRD-ELG-G--WSLEAGALVLGDQGNVCVDELDKMRSEDRSALH EALEQQTVSIAKAGIMATLNSRCSVLAAANPKFGRFDRY-KVLAEQID---LPAPIISRF DLIFVIEDKPSKERDSKLAEHILKTH----QFNT-------------------------- ----------------------------VDYEIEPELLRKYIAYARKNVNPR-LTEEANE VLKEFYVSTRNS-----N----PEEQGA--VPITARQLEAIIRLSEASAKIKLKETVDKE DAEKAVRLQLACLKEV-GVDPETG-ELDADIVSGGTP---KSDRDKIQRVTEEIK-QLEE ----EYA---G-QAPLNVLISNMSDKYGV-SED--KTEQIVKNLV-QKGVIYQPVN-GYF KRVV------ ;Minichromosome maintenance protein MCM [Thermoprotei archaeon] 62Thermoprotei_archaeon_RLE84985.1 ------------------------------------------------MFVEFF--KA-F ETEEG-FK-YRKLISS-MALDS-----RTS-LVIDW-QDLLSY-N--E---E--LANRLI -----DNPKEVLEAASQAIKDVMRI------ENPEFYEKVD--R--------FHARVR-- --GL--P--E-TLHVSIRGIR--AAHIGKLIAVEGVVTKISPVKQQLVEAVFR--CRN-- CGT---EITV---P--QN----EQ--SFVK-P-STCTRCEEE---G---RKR--S----- -------D---FEFIP------EKSKFLDWQRFVLQEKPEELPPGQLPRSIDVIL-KEDL VD-----TIRPGDRVTVIGFISISR---ERSRN----EGPP-LFRPYLEANYVEVSS--K ENMDLEITSEDVEKILKLSHRKDIRELIVSTIAPSIYG--YEKIKKAIAALLFGGV-PKV YPDG-VRVRGDIHILLVGDPGTAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLRYVAS-LAPRGI YTTGKGSTAAGLTAAVVRE-KST-GD-FFLEAGALVLADGGVACIDEFDKMDPKDRVSIH EAMEQQTVSIAKAGIVATLNARTSVLAAANPAFGRYMLN-RSVSENID---LPVTILSRF DLIFVMTDKPDKERDEELAEHVLDFH----SGRYP------------------------- --------------------------EHLESIIPAELLKKYIAYARRYIKPK-LSEEARK KLMDFYIEMRRK-----G----EGEGSP--IAITPRQLEALIRLAEAHAKMALSEVVTVE DAEAAIDLMNYFLHEV-GIDIETR-RLDIDVVMTGQS---MSQREKIMILMDLIK-RMIE ----ENEG--D-PVKREDVVAR-ATEMGF-DEL--FVRKVIEKLQ-ETGELMEPRP-GYI LRTVP----- ;minichromosome maintenance protein MCM [Vulcanisaeta moutnovskia] 63Vulcanisaeta_moutnovskia_WP_013604562.1 --------------------------------MTTQETTEVSLDDLIQGLRGFI--ES-S DR-------YVDEINNMIIQR------KRS-LVVDF-HDLLISSK------D--LADMLL -----ERPQLIIQAGSEAVRQAITE------RDPELAKSVR--N--------FYMRFR-- --RL--P--E---SLPIRRLR--SEVLSKFIMVEGIITRQTPPRHYLRKSVFR--CSQ-- CGY---EIEI---P--Q---P-TS--GFVQPP-KRCP--------KC--GAF--NS---- -----------MVFVE------ERSEFIDWQKVIVQEKPEELPPGQLPRSIEAIL-LDDL VD-----TVKPGDRVYLVGIMNLDL---ADLRK----GKPP-VVSSFMEVNYVESQQ--R ELVEIEITPEDEKKILELSKMPDVRERIIRSIAPSIYG--MEDIKEAIACLLFSGV-PKI YPDG-IRVRGDIHILLVGDPGMAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------TQLLRFVTK-IAPRAV YTTGKGSSAAGLTAAVVRE-KDT-GE-FYLEAGALVLADTGVAVIDEIDKMDAKDRVAIH EALEQQTVSIAKAGIVATLNARCSVLAAANPAFGRYLPN-RTVAENVD---LPVTLLSRF DLIFIIRDEPNLDRDKAIAEHITTLH----AGEVP------------------------- --------------------------EGFTDIIPPDLLRKYIAYARKHVKPV-LTHEARD RVVQFYVQMRAK-----S----REPDSP--IAITARQLEALIRLAEAEAKMRLSPVVEVE DADRAIRLFMKYLSSV-GIDVESG-KIDIDIIMTGKP---KSTQERMALIMNLLA-QLED ----SSGG--K-PVRIEDLYREAESA-GL-DRQ--AVDKAINMLL-KSGDIYMPKP-GYV KRVLV----- ;minichromosome maintenance protein MCM [Candidatus Thorarchaeota archaeon] 64Candidatus_Thorarchaeota_archaeon_TFG15271.1 --------------------------------------MSEYEVGPQERFEEFL--KS-Y KDEQGNAT-YWTRTQQMSINE------ETS-INVDF-QDLTSF--------DNVFLALSK -----EDPISFLQLADDALRSLLRT------EDPDYMAGIEEGL--------IKVRIV-- --NY--P--E---HVSLRSIR--SRHIGKLIHISGIMMRASEVKPLLVHATFR--CRR-- CGE---EISL---S------QEDG--RYIE-P-DQCP--------VC--GKK--T-P--- -----------VRLVP------EKSQFRDWQKVRIQESPEELPPGQMPRSVDVIL-EGDI VD-----ISRPGDLVKITGILMTAPD--FSRRR----GRLA-TFNVFIQANGVEIAE--K EYEQLELSEEDEKQIQELAEDPYVHERIVASIAPSIKG--HEDIKESIALLLFGGV-GKT LPDG-TRLRGRSNILMIGDPGTGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQILKFVSK-LASRSL YTSGKGTTAAGLTAAVVHD-TDS-GA-MTLEAGALVLADQGIACIDEFDKMDPNDRTAIH EAMEQHTVSIAKAGIVATLNARTSILAAANPTLGRYEPS-ASVQDNIK---LPFTILSRF DLMWILVDTVEATKDRELAQFILGMH-RMRRSET-------------------------- --------------------------DSKTPPIPPGFLKKYIGYAHRYVLPQ-LTVEAAE VIENFYVDLRKT-----A----EGGAAP--VPITARQLEALVRLSEARARMALKSKVSKE DAQASVRLMEESLKMV-ALDRITG-KIDIDRMVSKMS---AAQRSSSDTILKVMR-DMES ----EGI---S-TVSEEELIRRVEPL-GL-SKE--RAEEVIRKLV-AEGILFSPKH-GKL KRAQS----- ;Minichromosome maintenance protein MCM [Arc I group archaeon U1lsi0528_Bin089] 65Arc_I_group_archaeon_U1lsi0528_Bin089_KYC53990.1 --------------------------------------MKLSYEEIEDKFKELF--ES-Y PD-VSEPK-YKKIIDK-MKLEG-----KLS-IYINF-DDIIDF-N--F---D--LSEQLL -----SSPEEVFPAAIDALKEVYGA-----------EQGKR-----------LAVRIT-- --NL--PITE---RIDIKDIR--AVHINKLIQVEGVVRRTTEVKPEIIEAVFE--CER-- CGD---FITI--YQ------D-SI--IFKP-P-ITCSNPS------C--GRN--G-P--- -----------FKLMK------MHSTFVDWQSIKIQEKPEKLRGGQLPRSLDCTI-KEEI VD-----TAQPGNVVTIVGILKTLQ---EGAGK--TGGKKT-TFSKFLEVNSIEIKE--K DIQDLELSEEDEEKIRELASDPKICENITNSIAPSIYG--NQHVKYAVALQLFSSE-ARL LQDG-TRIRGDSHILLVGDPGVAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQILKYMNM-VAPRSI YTSGKGTSAAGLTAAVIRD-ETS-GT-FALEAGALVIADNGIACIDEIDKMSNDDRSSIH EAMEQQTVSIAKAGIIATLNARASILAAANPKRGRFDSY-KPLGEQID---LLPTLLSRF DLIFILTDKPKESEDKKIAEHILKLH----SNEE-------------------------- --------------------------DNITPPIETETIRKYAIYSKKTIQEISLTDEAKN RLLEFYVSIRKK-----G----EEKNTP--IPITARQLESLIRLSEARARMRLSDKVMVE DVEEIIQLYMKSIEDI-GKDPETG-EIDIDMIMTGRP---KSQRDKITIIMEIIS-NLDK ----KSNN--E-GALISELYEEARAE-NI-SDS--FTRKIIDELK-QKGDVYEPRP-DRL KLTLM----- ;Minichromosome maintenance protein MCM [Arc I group archaeon B03fssc0709_Meth_Bin005] 68Arc_I_group_archaeon_B03fssc0709_Meth_Bin005_KYC45172.1 --------------------------------------MKLNKEEVIDRFKEFY--EA-Y PD-VSEPK-YKKLIDK-MKIEG-----KSS-LYIDF-DDLIDF-D--F---D--LSEQLL -----NEPEDILASPSQALKEVYGA-----------EANKR-----------LTARFI-- --NL--PPTE---RIDIRDIR--AVHINKLIQVEGVVRRTSEVKPEVIEAVFS--CER-- CSE---YITI--MQ------D-SH--IFKT-P-VTCSNPA------C--GRN--G-P--- -----------FTLVK------TYSKFIDWQNIKIQEKPEKLKGGRLPWIMDCII-KDDI VD-----LAQPGNVVTIVGILKTVQ---EGSTK--SGGKKT-TFTKSIEVNSIEIKE--K DIQDLELSEEDEEKILELSSDPKICENITNSIAPSIFG--NQHVKYAVALQLFSSE-ARI LNDG-TRIRGDSHILLVGDPGVAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQILKYINL-VAPRSI YTSGKGTSAAGLTAAVIRD-ETS-GS-FALEAGALVIADNGIACIDEIDKMSNEDRSSIH EAMEQQTISIAKAGIIATLNARASILAAANPKRGRFDSY-KPLGEQID---LLPTLLSRF DLIFILTDKPKESEDKKIAEHILKLH----SNEK-------------------------- --------------------------QSIMPVLGTDEIRKYAIYSKKTIKEITLTEEAKN RLLEFYVSIRKK-----G----EEKNTP--IPITARQLESLIRLSEARARMRLSDKVMVE DVEDIIQLYMKSIEEI-GKDPETG-EIDIDMIMTGRP---KSQRDKITVIMDIIS-NLDK ----KNNN--E-GALTSEVYEEARAE-NI-SDS--FTRKIIDELK-QKGDVYEPRP-DRL KLTLL----- ;minichromosome maintenance protein MCM [Vulcanisaeta distributa] 69Vulcanisaeta_distributa_WP_013335643.1 --------------------------------MTTPETAEVSLDSLIQGLRGFI--ES-S DK-------YVDEINN-MIIQR-----KRS-LVIDF-HDLLIS-S--K---D--LADMLL -----ERPQLIIQAGSEAVRQAITE------RDPELAKSVR--N--------FYMRFR-- --RL--P--E---SLPIRRLR--SEVLGKLIMVEGIITRQTPPKHYLRKSVFR--CSQ-- CGY---EVEI---P--Q---P-TT--GFVQPP-KRCPK--------C--GAL--N-S--- -----------MVFVE------ERSEFIDWQKIIVQEKPEELPPGQLPRSIEAIL-LDDL VD-----TVKPGDRVYLVGIMNLDL---SDLKK----GRPP-VVSSFMEVNYVESQQ--R ELVEIEITPEDEKRILELSKMPDVRERIIKSIAPSIYG--MEDIKEAIACLLFGGV-PKV YPDG-IRVRGDIHILLVGDPGMAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------TQLLRFVTK-IAPRAV YTTGKGSSAAGLTAAVVRE-KDT-GE-FYLEAGALVLADTGVAVIDEIDKMDAKDRVAIH EALEQQTVSIAKAGIVATLNARCSVLAAANPAFGRYLPN-RTVAENVD---LPVTLLSRF DLIFIIRDEPNLDRDKAIAEHITTLH----AGEV-------------------------- -------------------------PEGFADIVPPDLLRKYIAYARKHVKPV-LTPEARE RIVQFYVQMRAK-----S----REPDSP--IAITARQLEALIRLSEAEAKMRLSPVVEAE DADRAIRLFMKYLSSV-GIDVESG-KIDIDIIMTGKP---KSAQERMALIMNLLA-QLEE ----SSGG--K-PVKIEDLYKEAEAA-GL-DRQ--AVDKAINMLL-KSGDIYMPKP-GYV KRVLI----- ;minichromosome maintenance protein MCM [Methanobrevibacter sp. YE315] 70Methanobrevibacter_sp._YE315_WP_067040762.1 ------------------------------------MNSTTKSQTSIAKFEEFF-ATS-- ---------YKDDVFKILEKYPD----ERS-LNVDY-QSLEIF-D--P---D--LADLLI -----DKPEEVIEAAQIAIKNIDPL-----------VKDAD-----------INIRFE-- --NL--S--N---IIPLKTLL--SKYIGTFVAADGIVRKTDEIRPRIETGVFE--CRG-- CMR---LHEV-EQT------S-AS--RIIE-P-SLCS--------EC--GGR--S----- -----------FRLLQ------EESKYIDTQTARMQEPLENLSGGTEPKQMLMIL-EDDL VD-----KLNPGDKVRITGTLKTFR------EE-----RSG-KFKNYIYVNHIEPLE--Q EFEELQLSEEDEEKILELSKDPHIYDKIIKSTAPSIKG--YRKVKEAIALQLFGGS-SKQ LEDD-TKLRGDIHILIVGDPGIGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQILKYVSR-LAPRSI YTSGKGTTGAGLTAAAVRD-ELG-G--WSLEAGALVLGDQGNVCVDELDKMRAEDRSALH EALEQQTVSIAKAGIMATLNSRCSVLAAANPKFGRFDSY-KVLAEQID---LPAPIISRF DLIFVIEDKPSREGDSELADHILEIH----KEKS-------------------------- ----------------------------IDYEIEPELLRKYIAYARKTVNPR-LTDEANK VLKEFYVSTRNN-----N----PEEQSA--VPITARQLEAIIRLAEASAKIKLKDTVDKE DAEKAVELQLACLKEV-GVDPETG-EMDIDIIDGRPA---KSDRDKIQRVTEEIA-LLEE ----EFA---G-SAPLEAIITNMNEKYNL-SEE--KVRSIVRNLQ-QKGIIYEPST-GYY RRLSS----- ;MULTISPECIES: minichromosome maintenance protein MCM [Methanobrevibacter] 71Methanobrevibacter_WP_016358964.1 ------------------------------------MSPSEKVNTTITKFEEFF--ST-- -Q-------YKDEVFDVLEKYPE----EKS-ITIQY-NDLEMF-D--P---D--LADHLI -----DAPNDVLSAAQSAIRNIDPL--------------VQNAD--------INVRIA-- --NL--S--N---VIPLNILL--SKYIGSFVAADGIVRKTDEIRPRIETATFE--CRG-- CTK---KYEV--EQ-----TS-QN--HIVE-P-SMCP--------NC--GGR--S----- -----------FRLLQ------EESHYIDTQTARMQEPLENLSGGTEPKQMLMVL-EDDL VD-----ELNPGDKVRITGVLKTFR---EDRSG---------KFKNYIYVNHIEPLE--Q EFEELKISEEDEEKIIELSQDPHIYDKIIKSTAPSIRG--YRNVKEAIALQLFGGA-AKV LEDD-TRLRGDIHILIVGDPGIGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQILKYVSK-LAPRSI YTSGKGTTGAGLTAAAVRD-ELG-G--WSLEAGALVLGDQGNVCVDELDKMREEDRSALH EALEQQTVSIAKAGIMATLNSRCSVLAAANPKFGRFDRY-KALAEQID---LPSPILSRF DLIFVIEDKPDVKNDSELAQHILDIH----QKNS-------------------------- ----------------------------VEYAIEPDLLRKYIAYARKNSNPK-LTNEAMD VLKEFYVSTRNS-----S----SEEQGP--VPITARQLEATIRLAEASAKIRLKDEVEAE DAKEAVKLQMACLKEV-GVDPETG-EIDIDKVEGRTP---SSDRDKMQKVIEEIS-SLQE ----EYG---D-QAPLNVLISNLEDNYNI-SED--KAERIIRTLK-QKGVIYEPSH-GYL KRV------- ;hypothetical protein tca_01716 [Methanothermobacter sp. EMTCatA1] 72Methanothermobacter_sp._EMTCatA1_BAZ99755.1 -------------------------------------MKTVDKSKTLTKFEEFF--SL-- QD-------YKDRVFEAIEKYPN----VRS-IEVGY-LDLEMF-D--P---D--LADLLI -----EKPDDVIRAAQQAIRNIDPL-----------RKNVD-----------LNIRFS-- --GI--S--N---VIPLRELR--SKFIGKFVAVDGIVRKTDEIRPRIVKAVFE--CRG-- CMR---LHEV--TQ------S-TN--MITE-P-SLCS--------EC--GGR--S----- -----------FRLLQ------DESEFLDTQTLKLQEPLENLSGGEQPRQITVVL-EDDL VD-----TLTPGDIVRVTGTLRTVR-------D----ERTK-RFKNFIYGNYTEFLE--Q EFEELQISEEDEEKIKELAGDPNIYEKIIRSTAPSIHG--YREVKEAIALQLFGGT-GKE LDDK-TRLRGDIHILIVGDPGIGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQMLKYVSK-LAPRGI YTSGKGTSGVGLTAAAVRD-EFG-G--WSLEAGALVLGDKGNVCVDELDKMREEDRSAIH EALEQQTISIAKAGIMATLNSRCSVLAAANPKFGRFDSY-KSIAEQID---LPSTILSRF DLIFVVEDKPDEEKDRELARHILKTH----KEDH-------------------------- ----------------------------MPFEIDPELLRKYIAYARKNVRPV-LTDEAMQ VLEDFYVSMRAS-----A----ADEDSP--VPITARQLEALVRLSEASAKIKLKEHVEAE DARKAIKLSQACLKQV-GYDPETG-KIDIDKVEGRTP---KSERDKFRLLLELIK-EYED ----DYG---G-RAPTNILITEMMDRYNV-SEE--KVEELIRILK-DKGAIFEPAR-GYL KIV------- ;Minichromosome maintenance protein MCM [Arc I group archaeon U1lsi0528_Bin055] 73Arc_I_group_archaeon_U1lsi0528_Bin055_KYC50146.1 --------------------------------------MKYSYEEVIDRFKEFY--EA-Y PD-VSEPK-YKKLIDKMKMEG------KSS-LYIDF-DDVIDF-D--F---D--LSEQIL -----KEPEQILTGPNAALKEVYGA-----------ETDKR-----------LTARFV-- --DL--PPTE---KIDIRDIR--AIHINKFIQVEGVVRRTTEVKPEVIEAVFS--CER-- CGE---YLTI-MQD--------SP--SFKT-P-VTCSNP------AC--GRN--G-P--- -----------FKLVK------AYSKFVDWQNIKIQEKPEKLKGGRLPWIMDCII-KDDI VD-----TAQAGNVVNIVGILKTVQ-ENWPKSG----GKKT-TFNKSIEVNSIGIKE--K DIQDLELSEEDEEKILELASDPKICENITNSIAPSIFG--NQHVKYAVALQMFSSE-ARL LHDG-TRIRGDSHILLVGDPGVAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQILKYINL-VAPRSI YTSGKGTSAAGLTAAVIRD-EGS-GS-FALEAGALVIADNGIACIDEIDKMSNEDRSSIH EAMEQQTISIAKAGIIATLNARASILAAANPKRGRFDSY-KPLGEQID---LLPTLLSRF DLIFILTDKPKESDDKKIAEHILKLH----SNEK-------------------------- --------------------------DSIIPILETEDIRKYAIYSKKTIKEITLTDDAKN RLLEFYVSIRKK-----G----EEKNTP--IPITARQLESLIRLSEARARMRLSDKVMVE DVEDIIKLYMKSIEEI-GKDPETG-EIDIDMIMTGRP---KSQRDKITVIMDIIS-NLDK ----KSNN--E-GALTSEVYEEARAE-NI-SDS--FTRKIIDELK-QKGDVYEPRP-DRL KLTLL----- ;minichromosome maintenance protein MCM [Methanothermobacter thermautotrophicus] 74Methanothermobacter_thermautotrophicus_WP_010877372.1 ------------------------------------MMKTVDKSKTLTKFEEFF--SL-- QD-------YKDRVFEAIEKYPN----VRS-IEVDY-LDLEMF-D--P---D--LADLLI -----EKPDDVIRAAQQAIRNIDRL-----------RKNVD-----------LNIRFS-- --GI--S--N---VIPLRELR--SKFIGKFVAVDGIVRKTDEIRPRIVKAVFE--CRG-- CMR---HHAV--TQ------S-TN--MITE-P-SLCS--------EC--GGR--S----- -----------FRLLQ------DESEFLDTQTLKLQEPLENLSGGEQPRQITVVL-EDDL VD-----TLTPGDIVRVTGTLRTVR---DERTK---------RFKNFIYGNYTEFLE--Q EFEELQISEEDEEKIKELAGDPNIYEKIIRSTAPSIHG--YREVKEAIALQLFGGT-GKE LDDK-TRLRGDIHILIVGDPGIGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQMLKYVSK-LAPRGI YTSGKGTSGVGLTAAAVRD-EFG-G--WSLEAGALVLGDKGNVCVDELDKMREEDRSAIH EALEQQTISIAKAGIMATLNSRCSVLAAANPKFGRFDSY-KSIAEQID---LPSTILSRF DLIFVVEDKPDEEKDRELARHILKTH----KEDH-------------------------- ----------------------------MPFEIDPELLRKYIAYARKNVRPV-LTDEAMQ VLEDFYVSMRAS-----A----ADEDSP--VPITARQLEALVRLSEASAKIKLKEHVEAE DARKAIKLSQACLKQV-GYDPETG-KIDIDKVEGRTP---KSERDKFRLLLELIK-EYED ----DYG---G-RAPTNILITEMMDRYNV-SEE--KVEELIRILK-DKGAIFEPAR-GYL KIV------- ;MULTISPECIES: minichromosome maintenance protein MCM [Methanobrevibacter] 75Methanobrevibacter_WP_004032260.1 ------------------------------------MNASTKSRTSVAKFEEFF-ATT-- ---------YKDDVFEILEKYPD----ERS-LTVDY-NDLEMF-D--P---D--LADLLI -----EKPEEVIEASKSAIKNIDPL--------------VKDAD--------INIRFE-- --NL--S--N---IIPLKTLL--SKYIGTFVAADGIVRKTDEIRPRIETGVFE--CRG-- CMR---LHEV---EQRS-----DS--RIIE-P-SLCS--------EC--GGR--S----- -----------FRLLQ------EESKYIDTQTARMQEPLENLSGGTEPKQMLMVL-EDDL VD-----QLNPGDKVRITGTLKTFR------EE-----RSG-KFKNYIYVNHIEPLE--Q EFEELQLTEEDEAKIIELSKDPDIYEKIIKSTAPSIRG--YRDVKEAIALQLFGGA-AKE LEDE-TRLRGDIHILIVGDPGIGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQMLKYVSK-LAPRSI YTSGKGTTGAGLTAAAVRD-ELG-G--WSLEAGALVLGDQGNVCVDELDKMRSEDRSALH EALEQQTVSIAKAGIMATLNSRCSVLAAANPKFGRFDRF-KILAEQID---LPSPILSRF DLIFVVEDKPSVKGDSELAQHILQIH----QQNT-------------------------- ----------------------------VNYEIEPELLRKYIAYARKNVNPK-LTDEANM VLKEFYVSTRNS-----S----GDEESP--VPITARQLEAIIRLAEASAKIRLKDTVDKE DAQKAVRLQLACLKEV-GVDPETG-EIDIDKVEGRTP---KSDRDKLQRIISEIE-ILEE ----EYA---G-QAPMNVLVSNMSDKYDM-SEE--KVDEMVRNLK-HKGVIYEPTN-GYL KRA------- ;minichromosome maintenance protein MCM [Methanothermobacter sp. CaT2] 76Methanothermobacter_sp._CaT2_WP_144245658.1 ------------------------------------MMKTVDKSKTLTKFEEFF--SL-- KE-------YKDRVFESIEKYPN----VRS-IEVDY-LDLEMF-D--P---D--LADLLI -----EKPDDVIRAAQKAIRNIDPL-----------RKNVD-----------LNIRFS-- --GV--S--N---VIPLRELR--SKFIGKFVAVDGIVRKTDEIRPRIVKAVFE--CRG-- CMR---LHEV--SQ------S-TN--MITE-P-SLCS--------EC--GGR--S----- -----------FRLLQ------DESEFLDTQTLKLQEPLENLSGGEQPRQITVVL-EDDL VD-----TLTPGDIVRVTGTLRTVR-------D----ERTR-RFKNFIYGNYTEFLE--Q EFEELQISEEDEEKIRELAADPNIYEKIIRSTAPSIHG--YREVKEAIALQLFGGT-GKE LDDK-TRLRGDIHILIVGDPGIGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQMLKYVSK-LAPRGI YTSGKGTSGVGLTAAAVRD-EFG-G--WSLEAGALVLGDKGNVCVDELDKMRDEDRSAIH EALEQQTISIAKAGIMATLNSRCSVLAAANPKFGRFDSY-KSIAEQID---LPSTILSRF DLIFVVEDKPDEEKDRELARHILKTH----KEDH-------------------------- ----------------------------TPFEIDPELLRKYIAYARKNVRPV-LTDEAMQ VLEDFYVSMRAS-----A----ADEDSP--VPITARQLEALVRLSEASAKIKLKEHVEAE DARKAIKLSQACLKQV-GYDPETG-KIDIDKVEGRTP---KSERDKFRLLLELIR-EYEE ----DYG---G-RAPTNILITEMMDRYNV-SEE--KVEELIRILK-DKGAIFEPAR-GYL KVV------- ;minichromosome maintenance protein MCM [Methanobrevibacter smithii] 77Methanobrevibacter_smithii_WP_019267683.1 ------------------------------------MNASTKSRTSVAKFEEFF-STT-- ---------YKDDVFEILEKYPD----ERS-LTVDY-NDLEMF-D--P---D--LADLLI -----EKPEEVIEASKSAIKNIDPL--------------VKDAD--------INIRFE-- --NL--S--N---IIPLKTLL--SKYIGTFVAADGIVRKTDEIRPRIETGVFE--CRG-- CMR---LHEV---EQRS-----DS--RIIE-P-SLCS--------EC--GGR--S----- -----------FRLLQ------EESKYVDTQTARMQEPLENLSGGTEPKQMLMVL-EDDL VD-----QLNPGDKVRITGTLKTFR------EE-----RSG-KFKNYIYVNHIEPLE--Q EFEELQLTEEDEEKIIELSKDPNIYEKIIKSTAPSIRG--YRDVKEAIALQLFGGA-AKE LEDE-TRLRGDIHILIVGDPGIGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQMLKYVSK-LAPRSI YTSGKGTTGAGLTAAAVRD-ELG-G--WSLEAGALVLGDQGNVCVDELDKMRSEDRSALH EALEQQTVSIAKAGIMATLNSRCSVLAAANPKFGRFDRF-KILAEQID---LPSPILSRF DLIFVVEDKPSVKGDSELAQHILQIH----QQNT-------------------------- ----------------------------VNYEIEPELLRKYIAYARKNINPK-LTDEANM VLKEFYVSTRNS-----S----GDEESP--VPITARQLEAIIRLAEASAKIRLKDTVDKE DAEKAVRLQLACLKEV-GVDPETG-EIDIDKVEGRTP---KSDRDKLQRIISEIE-LLEE ----EYA---G-QAPMNVLISNMSDKYDI-SEE--KVDEMVRNLK-HKGVIYEPTN-GYL KRA------- ;minichromosome maintenance protein MCM [Methanobrevibacter smithii] 78Methanobrevibacter_smithii_WP_019264387.1 ------------------------------------MNASTKSRTSVAKFEEFF-STT-- ---------YKDDVFEILEKYPD----ERS-LTVDY-NDLEMF-D--P---D--LADLLI -----EKPEEVIEASKSAIKNIDPL--------------VKDAD--------INIRFE-- --NL--S--N---IIPLKTLL--SKYIGTFVAADGIVRKTDEIRPRIETGVFE--CRG-- CMR---LHEV---EQHS-----DS--RIIE-P-SLCS--------EC--GGR--S----- -----------FRLLQ------EESKYVDTQTARMQEPLENLSGGTEPKQMLMVL-EDDL VD-----QLNPGDKVRITGTLKTFR------EE-----RSG-KFKNYIYVNHIEPLE--Q EFEELQLTEEDEAKIIELSKDPNIYEKIIKSTAPSIRG--YRDVKEAIALQLFGGA-AKE LEDE-TRLRGDIHILIVGDPGIGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQMLKYVSK-LAPRSI YTSGKGTTGAGLTAAAVRD-ELG-G--WSLEAGALVLGDQGNVCVDELDKMRSEDRSALH EALEQQTVSIAKAGIMATLNSRCSVLAAANPKFGRFDRF-KILAEQID---LPSPILSRF DLIFVVEDKPSVKGDSELAQHILQIH----QQNT-------------------------- ----------------------------VNYEIEPELLRKYIAYARKNINPK-LTDEANM VLKEFYVSTRNS-----S----GDEESP--VPITARQLEAIIRLAEASAKIRLKDTVDKE DAEKAVRLQLACLKEV-GVDPETG-EIDIDKVEGRTP---KSDRDKLQRIISEIE-LLEE ----EYA---G-QAPMNVLISNMSDKYDI-SEE--KVDEMVRNLK-HKGVIYEPTN-GYL KRA------- ;minichromosome maintenance protein MCM [Methanobrevibacter smithii] 79Methanobrevibacter_smithii_WP_019266375.1 ------------------------------------MNASTKSRTSVAKFEEFFSTT--- ---------YKDDVFEILEKYPD----ERS-LTVDY-NDLEMF-D--P---D--LADLLI -----EKPEEVIEASKSAIKNIDPL-----------VKDAD-----------INIRFE-- --NL--S--N---IIPLKTLL--SKYIGTFVAADGIVRKTDEIRPRIETGVFE--CRG-- CMR---LHEV-EQR--S-----DS--RIIE-P-SLCS--------EC--GGR--S----- -----------FRLLQ------EESKYVDTQTARMQEPLENLSGGTEPKQMLMVL-EDDL VD-----QLNPGDKVRITGTLKTFR---EERSG---------KFKNYIYVNHIEPLE--Q EFEELQLTEEDEAKIIELSKDPNIYEKIIKSTAPSIRG--YRDVKEAIALQLFGGA-AKE LEDE-TRLRGDIHILIVGDPGIGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQMLKYVSK-LAPRSI YTSGKGTTGAGLTAAAVRD-ELG-G--WSLEAGALVLGDQGNVCVDELDKMRSEDRSALH EALEQQTVSIAKAGIMATLNSRCSVLAAANPKFGRFDRF-KILAEQID---LPSPILSRF DLIFVVEDKPSVKGDSELAQHILQIH----QQNT-------------------------- ----------------------------VNYEIEPELLRKYIAYARKNINPK-LTDEANM VLKEFYVSTRNS-----S----GDEESP--VPITARQLEAIIRLAEASAKIRLKDTVDKE DAEKAVRLQLACLKEV-GVDPETG-EIDIDKVEGRTP---KSDRDKLQRIISEIE-LLEE ----EYA---G-QAPMNVLISNMSDKYDI-SEE--KVDEMVRNLK-HKGVIYEPTN-GYL KRA------- ;minichromosome maintenance protein MCM [Methanobrevibacter smithii] 80Methanobrevibacter_smithii_WP_100198697.1 -------------------------------------MLVQNHEHLLQKFEEFF--ST-- -T-------YKDDVFEILEKYPD----ERS-LTVDY-NDLEMF-D--P---D--LADLLI -----EKPEEVIEASKSAIKNIDPL--------------VKDAD--------INIRFE-- --NL--S--N---IIPLKTLL--SKYIGTFVAADGIVRKTDEIRPRIETGVFE--CRG-- CMR---LHEV---E--QR--S-DS--RIIE-P-SLCS--------EC--GGR--S----- -----------FRLLQ------EESKYVDTQTARMQEPLENLSGGTEPKQMLMVL-EDDL VD-----QLNPGDKVRITGTLKTFR------EE-----RSG-KFKNYIYVNHIEPLE--Q EFEELQLTEEDEEKIIELSKDPNIYEKIIKSTAPSIRG--YRDVKEAIALQLFGGA-AKE LEDE-TRLRGDIHILIVGDPGIGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQMLKYVSK-LAPRSI YTSGKGTTGAGLTAAAVRD-ELG-G--WSLEAGALVLGDQGNVCVDELDKMRSEDRSALH EALEQQTVSIAKAGIMATLNSRCSVLAAANPKFGRFDRF-KILAEQID---LPSPILSRF DLIFVVEDKPSVKGDSELAQHILQIH----QQNT-------------------------- ----------------------------VNYEIEPELLRKYIAYARKNINPK-LTDEANM VLKEFYVSTRNS-----S----GDEESP--VPITARQLEAIIRLAEASAKIRLKDTVDKE DAEKAVRLQLACLKEV-GVDPETG-EIDIDKVEGRTP---KSDRDKLQRIISEIE-LLEE ----EYA---G-QAPMNVLISNMSDKYDI-SEE--KVDEMVRNLK-HKGVIYEPTN-GYL KRA------- ;MULTISPECIES: minichromosome maintenance protein MCM [Thermococcus] 81Thermococcus_WP_088179816.1 ----------------------------------------MDREDMIERYARFL--RE-Y VDDSGNEV-YLNKLKDLLTVTP-----KRS-LAIDW-THLNSF-D--P---E--LAGELL -----ENPEESILAAEDAIQIVLRE------PPLLKEEEFK-----------VHARFY-- --NL--P--R---TLLVKELG--SEHINRLIQVEGIITRVSEVKPFVEKAVFV--CKD-- CGN--EMVRLQRP---------YE--NIVK-P-SKCD--------AC--GSR--N----- -----------VDLDV------EKSRFINFQSFRLQDRPESLKGGQMPRFVDAIL-LDDL VD-----TALPGDRILATGILRVIL-----EQK----DKRP-IFKKVLEVNHIEQLS--K EIEELEISPEDEQKIRELAKRKDIVDAIVDSIAPAIWG--HKTVKKGIALALFGGV-QRT LPDG-TKLRGESHVLLVGDPGVAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQILRYVAN-LAPRAI YTSGKSSSAAGLTAAAVRD-EFT-GS-WVLEAGVLVLADGGFALIDEFDKMSDRDRSAIH EALEQQTISISKAGITATLNARTTVIAAANPKYGRFNRH-KSLPEQLD---LPPTLLSRF DLIFLLLDEPDEKVDSSIAEHILKVR----RGEA-------------------------- --------------------------EAVTPKIPYELLKKYIAYARKNVHPV-LSREAME EIKRYYVRMRKG-FKRPGE---DDGVQP--IPITARQLEALIRLSEAHARMRLSETVTRE DARAAIAIIEDMIRKI-AVD-EEG-TLDVSILEVGKS---SKKINKIDRMVDIIK-SLES ----EGE---F-GAPEDRILEAAKQA-GLGSEN--EIKKLINDLK-RDARIYEPRA-GFY RVL------- ;minichromosome maintenance protein MCM [Thermofilum pendens] 82Thermofilum_pendens_WP_011752169.1 -------------------------------------MVVTQAIPLTERITEFL--KRFT VD--GREK-YRDAIRRMSIER------SIS-LVIDF-DDLLLF-D--K---E--LADILL -----ERPHDFLDAASKAIMEVLKI------ENPDYAKEVGY----------VHARIR-- --RP--P--E-IVHLKIRNIR--ARHLGRLVAVEGIVTKISPVKQELVEGVFK--CKT-- CGT---ELTV---P------QGPE--GLTK-P-TTCP--------VC--SEN--GVKSAG -----------FVLLP------EKSKFVDLQKFVLQEKPEELPPGQLPRSIEVLV-REDL VD-----VVRPGDRATVVGFLRMEE--DKKLVK----NAPP-IFHAYLEANYVEVSA--K ENLDVEITPEDEKKILELSRREDLEEIIINSIAPSIYG--YKEIKTAIALLLFGGV-PKI HPDG-IRVRGDIHILLIGDPGTAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLRYVAS-IAPRGL YTSGKGASAAGLTAAVVKE-KNS-GE-FYLEAGALVLADGGVACIDEFDKMEAKDRVSIH EAMEQQTVSIAKAGIVATLNARASILAAANPAFGRYLPG-RNISENID---LPVTILSRF DLIFVVRDTPNAERDRELAQYVVDFH-----GET-------------------------- ------------------------YPVSLEKVLDAQTLKKYIAYARRHVRPR-LSPEAKS KIVEYYVNMRKK-----S----EDASSP--IAITPRQLEALIRLSEAHARMHLRDVVTAR DAEVAISLMEYFLRNV-GIDTQTM-TIDIDTIMTGQP---KSQREKLIAVLDTVK-NLVR ----QNNG--E-PIKEEDLYSELEKN-GI-DRN--FARKAIEKLL-EQGELMQPSP-GRI SVVSL----- ;minichromosome maintenance protein MCM [Methanothermobacter marburgensis] 83Methanothermobacter_marburgensis_WP_013295175.1 ------------------------------------MMKTVDKSKTLTKFEEFF--SL-- KK-------YKDRVFESIEKYPN----VRS-IEVDY-LDLEMF-D--P---D--LADLLI -----EKPDDVIRAAQKAIRNIDPL-----------RKNVD-----------LNIRFS-- --GV--S--N---VIPLRELR--SKFIGKFVAVDGIVRKTDEIRPRIVKAVFE--CRG-- CMR---LHEV-SQS--------TN--MITE-P-SLCS--------EC--GGR--S----- -----------FRLLQ------DESEFLDTQTLKLQEPLENLSGGEQPRQITVVL-EDDL VD-----TLTPGDIVRVTGTLRTVR---DERTR---------RFKNFIYGNYTEFLE--Q EFEELQISEEDEEKIKELAADPNIYEKIIRSTAPSIHG--YREVKEAIALQLFGGT-GKE LDDK-TRLRGDIHILIVGDPGIGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQMLKYVSK-LAPRGI YTSGKGTSGVGLTAAAVRD-EFG-G--WSLEAGALVLGDKGNVCVDELDKMRDEDRSAIH EALEQQTISIAKAGIMATLNSRCSVLAAANPKFGRFDSY-KSIAEQID---LPSTILSRF DLIFVVEDKPDEDKDRELARHILKTH----KEDH-------------------------- ----------------------------TPFEIDPELLRKYIAYARKNVRPV-LTDEAMQ VLEDFYVSMRAS-----A----ADEDSP--VPITARQLEALVRLSEASAKIKLKEHVEAE DARKAIKLSQACLKQV-GYDPETG-KIDIDKVEGRTP---KSERDKFRLLLELIR-EYEE ----DYG---G-RAPTNILITEMMDRYNV-SEE--KVEELIRILK-DKGAIFEPAR-GYL KVV------- ;minichromosome maintenance protein MCM [Methanobrevibacter woesei] 84Methanobrevibacter_woesei_WP_116669278.1 -----------------------------------MSTSTTKIGTSVAKFEEFF--ST-- --------IYKDQLFETLEKYPD----ERS-LEIDY-NNLEMF-D--P---D--LADLLI -----EKPQEILDAATNAIKNIDPL-----------VKDVD-----------INLRIA-- --NL--T--N---IIPLKTLL--SKYIGNFVAADGIVRKTDEIRPRIETAVFE--CRG-- CMR---LHEV---E--QS--S-DS--RIVE-P-SLCS--------EC--GGR--S----- -----------FRLLQ------EESKYIDTQTARMQEPLENLSGGTEPKQMLMIL-EDDL VD-----KLNPGDKVRITGTLKTFR-------E----ERSG-KFKNYIYVNHIEPLE--Q EFEELHLTPEDEEEIIELSKDPNIYDKIIKSTAPSIKG--YRDVKEAIALQLFGGS-AKQ LADE-TRLRGDIHILIVGDPGIGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQMLKYVSK-LAPRSI YTSGKGTTGAGLTAAAVRD-ELG-G--WSLEAGALVLGDQGNVCVDELDKMRSEDRSALH EALEQQTVSIAKAGIMATLNSRCSVLAAANPKFGRFDRF-KLLAEQID---LPSPILSRF DLIFVVEDKPSIKNDSELADHILEIH----QSNE-------------------------- ----------------------------INYEIEPELLRKYIAYARKNVNPR-LTDEANT VLKEFYVSTRNS-----G----QDEEGP--VPITARQLEAIIRLAEASAKIRLKETVDKE DAEKAVRLQLACLKEV-GIDPETG-EIDIDKVEGRTP---KSDRDKLQRVLEEIE-LLEE ----EYG---G-QAPTNVLASNMADKYDI-SEE--KVENIIRNLK-HKGIIYEPTS-GYL KRA------- ;replicative DNA helicase Mcm [Methanothermobacter defluvii] 85Methanothermobacter_defluvii_REE24592.1 -------------------------------------MKTVDKSKTLTKFEEFF--SL-- QD-------YKDRVFEAIEKYPN----VRS-IEVDY-LDLEMF-D--P---D--LADLLI -----EKPDDVIRAAQQAIRNIDRL-----------RKNVD-----------LNIRFS-- --GV--S--N---VIPLRELR--SKFIGKFVAVDGIVRKTDEIRPRIVKAVFE--CRG-- CMR---LHEV--TQ------S-TN--MITE-P-SLCS--------EC--GGR--S----- -----------FRLLQ------DESEFLDTQTLKLQEPLENLSGGEQPRQITVVL-EDDL VD-----TLTPGDIVRVTGTLRTVR---DERTK---------RFKNFIYGNYTEFLE--Q EFEELQISEEDEEKIKELAGDPNIYEKIIRSTAPSIHG--YREVKEAIALQLFGGT-GKE LDDK-TRLRGDIHILIVGDPGIGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQMLKYVSK-LAPRGI YTSGKGTSGVGLTAAAVRD-EFG-G--WSLEAGALVLGDKGNVCVDELDKMREEDRSAIH EALEQQTISIAKAGIMATLNSRCSVLAAANPKFGRFDSY-KSIAEQID---LPSTILSRF DLIFVVEDKPDEDKDRELARHILKTH----KEDH-------------------------- ----------------------------MPFEIDPELLRKYIAYARKNVRPV-LTDEAMQ VLEDFYVSMRAS-----A----ADEDSP--VPITARQLEALVRLSEASAKIKLKGHVEAE DARKAIKLSQACLKQV-GYDPETG-KIDIDKVEGRTP---KSERDKFRLLLELIK-EYED ----DYG---G-RAPTNILITEMMDRYNV-SEE--KVEELIRILK-DKGAIFEPAR-GYL KIV------- ;hypothetical protein A3K78_09975 [Candidatus Bathyarchaeota archaeon RBG_13_52_12] 86Candidatus_Bathyarchaeota_archaeon_RBG_13_52_12_OGD57966.1 ---------------------------------------MAKQVSHEEVFTRFI--ED-F RNPEGVLK-YEQNIQE-MPIKG-----VSS-LIVDF-NDVYNY-D--M---E--LAADVI -----NDPDKILELFSRVVYDKLRQ------RDLVWAEAQK--K--------IHVRFR-- --AL--P--S---VTQLRRIG--SEHISRLVMVQGIIVRASATTPQVMKAVFR--CSN-- CNE---LNYV---E--QD----GE--TLKT-P-IKCE--------HC--DSK--T----- -------R---FDLVP------KLSVFMDSQRITIQERPEDLPPGQLPRSLHVDL-KDDI VD-----QARPGDRITLVGSVNLLQ---RFGRG----GQLR-IFDMVMEASHLEVSG--R ESEMTDISPADEDKIKEIAQDPWVHRRLLQSIAPSIFG--LENIKESILYLLFGGL-SKE LPD--VRIRGDINVLLVGDPGTGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLQFAAK-IAPRGL MTTGRGSTAAGLTAAVVKE-GGT-GN-FILEAGALVLSDQGICCIDEIDKMREEDRGAIH PAMEQQIVPIAKGGIVATLNARTSILAAANPTLGRYNPY-QTIGQNIN---LPVTILSRF DVIFVIKDVPDAEKDATMADHILGLH--RAAGST-------------------------- ----------------------------ITSPIDPELFRKYISYAKTRVRPI-LNEEVIT RFKDFYVKMRTA-------SIEGGEASA--VSITARQLESLVRLAEARAKAHLRSEVTKE DAEAVITLMQTSLEQV-GIDVSTG-QIDIDILYTGKP---RSLQTQLQKVLAKIV-ELER -----TG-----PVKDDDLYEALAEE-GI-NRS--EAAKLISTLM-RDGTIFSPRP-GTY RRTS------ ;minichromosome maintenance protein MCM [Methanothermobacter defluvii] 87Methanothermobacter_defluvii_WP_115892823.1 ------------------------------------MMKTVDKSKTLTKFEEFF--SL-- QD-------YKDRVFEAIEKYPN----VRS-IEVDY-LDLEMF-D--P---D--LADLLI -----EKPDDVIRAAQQAIRNIDRL-----------RKNVD-----------LNIRFS-- --GV--S--N---VIPLRELR--SKFIGKFVAVDGIVRKTDEIRPRIVKAVFE--CRG-- CMR---LHEV-TQS--------TN--MITE-P-SLCS--------EC--GGR--S----- -----------FRLLQ------DESEFLDTQTLKLQEPLENLSGGEQPRQITVVL-EDDL VD-----TLTPGDIVRVTGTLRTVR---DERTK---------RFKNFIYGNYTEFLE--Q EFEELQISEEDEEKIKELAGDPNIYEKIIRSTAPSIHG--YREVKEAIALQLFGGT-GKE LDDK-TRLRGDIHILIVGDPGIGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQMLKYVSK-LAPRGI YTSGKGTSGVGLTAAAVRD-EFG-G--WSLEAGALVLGDKGNVCVDELDKMREEDRSAIH EALEQQTISIAKAGIMATLNSRCSVLAAANPKFGRFDSY-KSIAEQID---LPSTILSRF DLIFVVEDKPDEDKDRELARHILKTH----KEDH-------------------------- ----------------------------MPFEIDPELLRKYIAYARKNVRPV-LTDEAMQ VLEDFYVSMRASA---------ADEDSP--VPITARQLEALVRLSEASAKIKLKGHVEAE DARKAIKLSQACLKQV-GYDPETG-KIDIDKVEGRTP---KSERDKFRLLLELIK-EYED ----DYG---G-RAPTNILITEMMDRYNV-SEE--KVEELIRILK-DKGAIFEPAR-GYL KIV------- ;Minichromosome maintenance protein MCM [Candidatus Thorarchaeota archaeon] 88Candidatus_Thorarchaeota_archaeon_RLI56060.1 ---------------------------------------MTEPRDTKDRLVEFL--RT-F KDEQGKTI-YWDRVQVMPERE------QVS-LIVDF-QDLMTE-D--P---T--FVTDAA -----ENPIAFLKMADEALVSVMRT------DNAEYVESLDKSL--------IKLRFI-- --NH--P--D---HVKLRAIR--ARHIGKFINVGGVMMRASEVKPLLVETTFQ--CRL-- CDT---EIPQ-VQE--------DG--RYTE-P-PVCP--------TC--EKK--T-P--- -----------LKMLP------QKSTFQDWQKVRIQESPEELPAGQMPRSIDVIL-KGDI VD-----ISRPGDFIRVTGILKTSPD--FSRRG----SRLA-TFNTFIEANGVEVSE--K EYEQLDITDEEKQAIDDLAQDPFVHTRIIKSIAPSIKG--HEYVKKSIALLLFGGR-EKL LPDG-TRLRDKSNILMIGDPGTGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQILKFVSD-LAPRGL YTSGKGTTAAGLTAAVVHD-TDS-GA-MTLEAGALVLADKGIACIDEFDKMDPNDRTAIH EAMEQHTVSIAKAGIVATLNARTSILAAANPTLGRYEPS-MNVQDNIR---LPFTILSRF DLIWIMVDTVEATKDRALARHILDLH----QMKKI-K----------------------- -------------------------EPDEIPPIDPVFLKKYIGHAAQNVHPD-LSQEAAD VIEEYYVDMRKQ-----A----EGGRAP--VPITARQLESLVRLAEAHAKMALRSEVTRE DAQEAIDLMKQSLLMV-AFNPETG-QYDIDRTQASMD---STQRSASDTVLKALQ-AIES ----ETD---RTTVDREALVERASSM-GI-SRD--KAEQTIELLI-RDGILFSPRE-GKI RHHLSTG--- ;AAA family ATPase [Methanophagales archaeon] 89Methanophagales_archaeon_PXF52786.1 --------------------------------------MAQNLDLTTERWEDFL--KR-Y ---------CWDELVELSNYYPE----KRS-LFVKF-TDMDLY-D--P---N--LADMVL -----ESPDVAINAATRALRAIDTP------------TGVTLDE--------ANFRII-- --KV--P--R---RLKIRDIR--SEDIGKLVSIEGLVTKATEVRPKVVEAVFE--CPF-- CHH---VFSV---E--Q---S-GR--QFKE-P-VECDQESGG----C--GRK--SQH--- -----------FKLLL------EQCKFANAQKIQLQESPEELRGGELPQAIDVYL-EDDI TG-----GVTPGDRVIITGILRSYQ---RTTRF----GKTP-FFDIYLEGNSLEHKE--E EFEEIKITEEDEQRIMELKNQPDVYEKLIMSIAPSIYG--YEEIKEAMVLQLFAGV-PKE LPDE-TRIRGDIHVLLVGDPGVAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLTYLVK-LAPRGL YTGGKSSTSAGLTAAAVKD-EFGEGR-WTLEAGALVLADKGIAAVDEIDKMRKEDRDALH EAMEQQTVSVAKAGIMARLNSRCGLLAAANPKYGRFDKY-TPIAEQIN---MPPTLLSRF DLIFTMMDRPNEEADTKTAEHIIETH---YAGELL-A----------------------R AKNVSKINRAER-------EHFERAVAVMKPPIESDLLRKYVAWSKRNVFPV-MSEGARR RFLEFYIGLRRQ-----GY---EDEDAP--VPVTARQLEALIRLGEARARARLSDEITEE DADRVINIVTYCLKRV-FVDPETG-RLDTDWVTVGIT---KTKRDRARSIREIIK-DLER ----EYG---D-EVPLEEVLDLAEEE-GM-ERE--KAEEIIEVMK-RDGILFSPSS-GIV KFVR------ ;Minichromosome maintenance protein MCM [Thermoprotei archaeon] 90Thermoprotei_archaeon_RLG74742.1 ----------------------------MTVEEVEAPMIEAKEVDLKLQFRDFF--KT-F KDKQGKLK-YWNKILDIAIKG------EKS-LIVDF-PDLLLT-K--P---D--LALKVL -----EEPRITLEYASEALKDIVRG------ENPELVERTEK----------FYVRFR-- --NL--P--R---TVPIRKLG--AEHIERLVQIEGIITRMTPVIQRLYKAVFK--CLE-- CGS---ETKV-LQE--------EE--TIEY-P-ELCG--------FCEERKRTKIESRKA RPQ--------FKLLL------HKSKFINMQKIIVQEKPEDVPPGHMPRSVEVVL-LEDL VD-----KARPGDRVTVVGILTVKG--ERSVKK----GTKL-TFEMKIEANSLEVSQ--K VLEEIEISKEDERKILELAKDPKIREKIVQSIAPAIHG--YNHIKKAIALLLFGGV-PKE LPDG-TRIRGDIHILLVGDPGVAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQILQYIAR-IAPRGL YTSGKGSSAAGLTAAVIRD-KST-GE-YFLEAGALVLADGGICAIDEIDKMRPEDRVAIH EAMEQQTISIAKAGIVARLNARTAILAAGNPKFGRYIED-RLFTENIN---LPPTILSRF DLIFVMRDKPAPQTDEELVSHILTVH---KQYER-------------------------- ----------------------------VKPPISPSLLRKYVGYARKYVKPR-LTEEAAK IISDFFVNLRSK-----AS---ENPNAP--IPITPRQLEAIIRLAEAHARMVLRNEVTAE DAKAAIDLVVRSFKDV-GLDIEAG-VIDIDIIMTGKP---VSRRLKIMKVMEIIE-KLE- ----EYP---GAEVKKSDVIEQAVKS-GL-DAK--EVEEILDQLR-REGSLYEPRL-GKI ARTM------ ;minichromosome maintenance protein MCM [Candidatus Verstraetearchaeota archaeon] 92Candidatus_Verstraetearchaeota_archaeon_RZN56958.1 ------------------------------------MEIIQETIDYREKFAEFL--KS-F QDRNGNFK-YRDAIAQMASLG------KTS-LVIDF-EDLMSY-D--A---N--LAKELK -----ERPEVVIQRANLAITDVMRT------VNMNYAARVKE----------FRARFR-- --KL--D--E---VIPLRALK--ASLINKLIMVEGIITRTSFVKQLIKIAKFQ--CPL-- CKE---KFEI-EQT--------GT--ILVS-P-VQCPNP------DC--RKK--GN---- -----------FRLLT------EESKFVDWQMIQLQERPEELPPGRLPRSIDCIL-QEDL VD-----TIRPGDRVYIIGVLKARQ------DA----SKMA-TFSSFIDVNYVEISE--K GLEEIEITPEDEKAIIELSKDPLLYQKIFSSIAPSIYG--YEEIKEAIAYQLAGGV-PKV MPDG-VKVRGDIHILLVGDPGTAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLQYVAR-IAPRGI YTSGKGSTAAGLTATVVRD-KTT-HE-FFLEAGALVLADRGYACIDEIDKMRSEDRVALH EAMEQQTISIAKAGIVVQLNARTSILAAANPTFGRYVPQ-RSIAENLS--DLPVTIISRF DLIFTLMDRPEEARDRAMSEHILSLH----QGAT-------------------------- --------------------------SVKSPPISPDLLKKYFYYVRKNIKPI-LTDRAIK KIEEFFLEMRKK-----G----EGSDSP--VPITVRQLESIIRLSEARAKLALKKEVTEE DVEPVIKLMKSFLFQV-GIDRTTG-KLDIDTIMVGRP---KSISDKLAALFDLLI-TMEK ----ENN---MAPVKKEAFISRAENE-GF-SRN--FVENALIKWT-NEGIIYEAKP-GYI KKA------- ;Minichromosome maintenance protein MCM n=2 Tax=Candidatus Heimdallarchaeota TaxID=1936272 RepID=A0A1Q9P483_9ARCH 1Candidatus_Heimdallarchaeota__UniRef50_A0A1Q9P483 ----------------------------------MNNMAIDTRDELYEAYLDFF--KS-F QTDEGEFK-YVTNINKMIREG------ERS-LIIDY-DDLVLM-DDIN---DMEISSTLT -----EKPYFTIEIGSEALAEQVRI------ENPDYHREISADNDH------FSVRFA-- --NP--P--T---PIQIRDLR--ANHVDSIRWLEGIVIRTTEIKSIITEAVYY--CTE-- PNQHRNLIMF---Q--------DG--IYSR-P-DRCFVE------TC--KAK--E----- -----------FILDP------RESKMIDWQIITLQEKPEDLPPGASPKSLPCRL-IDDI VN-----AVRPGDRVHLGGLVRSRP--SKIAKK----GQIL-TYDIWVDVNYIESLT--K EEQYADLTLEEEKEFRELAQDPKIHDRLLESVAPAIFG--MEKEKEATLLMLFGGV-DKV FPDG-FTTRGQSNMLLVGDPGVAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLRYVKS-IAPRGL YTSGRGSSAAGLTAAIIRD-PDT-GE-IALEAGALVLADRGICLIDEFDKMNENDRSAIH EAMEQHTISIAKAGIVATLNARTGVLAAANPKYGRYEPH-RTFSENVN---LSPAILSRF DLVFIIKDEPDAEKDQVLASHILKLH--RFHGTA-------------------------- --------------------------QSIIPPISEEKLKKYIAFAKTYYSPT-LTEEATE VIEEYYVNMRMS-VGSSN----DDGIKRNRVTITARQLEGIVRMAEARARAGLRSTVTKH DALKAIELMQYSLNQI-AIDPATG-EADIDGFYSGHT---SSKRSKLTKLLSIID-FLYR ----DSGG--K-PFEESLLLQEAETE-GI-TQE--YAKGVVQQML-RDGQLYQPKA-GWI KRPDA----- ;DNA replication helicase protein MCM n=3 Tax=Candidatus Verstraetearchaeota TaxID=1915410 RepID=A0A444L8Y0_9ARCH 2Candidatus_Verstraetearchaeota__UniRef50_A0A444L8Y0 ------------------------------------MTETVEIVDYRERFVSFL--KE-F QDSKGAFK-YRDAMSSMASQG------KTS-LVVDF-EDVISF-D--P---D--LAKDIK -----ERPLELLPKINAAIYDAMRA------ENMQYAAKIKN----------FKARFR-- --KL--D--E---VVPLRSLK--SAHMGKLIMVEGIITRASAVKQLLKTAVYQ--CPR-- CGE---KIVL----------EQTG--NILMPP-SQCTNQ------DC--ARK--GY---- -----------FRLLP------EESVFVDWQLISVQEKPEELPPGQLPRSVEGIL-QGDI VD-----TSRPGDRVSLVGILQAKQE--FTSRG----FRLA-TFSSGIEANHLEISE--R GTEEVAITPEDEKAIKKLASDPNLYDKLIGSIAPSIYA--YDEIKEAVAYQLAGGV-TKT MPDG-IKIRGDINILLVGDPGTAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLQYVSR-IAPRGV YTSGKGSTAAGLTATVIRD-KNT-GE-FFLEAGALVIADKGIACIDEIDKMRPEDRSAIH EAMEQQTISIAKAGIVVQLNARSSILAAANPSFGRYVPQ-KTISENIN--DLPVTILSRF DLIFTLLDRPDELKDRKMTEHILNLH----RGIR-------------------------- --------------------------VTKESPIDPELLKKYIYYVRKHGSPK-IGEDASK AIEDFFLEMRAM-----G----QGADSP--VPITMRQLEAVIRLSEARAKLALKKEVSKE DVQAVIRLLKTFLKQV-GIDSSTG-KIDIDTIMVGHP---KSQGDKMAQLFDIFR-EMEK ----ENEG--R-PVRKEALIERAGLE-GL-DRK--FVERAVIEWI-NQGVIYEPKH-GEL KKA------- ;MCM domain-containing protein n=18 Tax=Archaea TaxID=2157 RepID=A0A135VA84_9ARCH 3Archaea__UniRef50_A0A135VA84 --------------------------------------MTLEMETEQERFEEFI--RT-F KDEQGSTV-YWSRVQQMSIDD------ESS-LVVDF-QDLIGF-D--N---V--FMAFAT -----EDPQTFLRMAHNALVSILKI------EDPEYVGTIGHDG--------LQVRII-- --NY--S--E---NVPLRHIR--SRHIGKLIRISGIMMRASEVKPLLVNATFQ--CRV-- CMA---EIPQ-EQE--------EG--RYTE-P-PLCS--------TC--GKK--T-P--- -----------MKLLL------AKSRFIDWQKVRIQESPEELPPGQMPRSVDVVL-KGDI VD-----ISRPGDMVKVTGLLQTTP--DFSRRG----GKLA-TFNVFIEANGVEIAE--K EYEQLEISEEDEKAINELSKNPYIHEKIYRSIAPAIQG--HDEIKQSISLLLFGGV-DKT LPDG-TRLRGRSNILMVGDPGTGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQILKFVSG-LASRAL YTSGKGTTAAGLTAAVIHD-ADS-GA-MTLEAGALVLADQGIACIDEFDKMDPNDRTAIH EAMEQHTVSIAKAGIVATLNARTSILAAANPTLGRYETS-WTPQENIK---LPFTILSRF DLVWVMIDTPNEERDKELARFILDMH----QGKP-------------------------- -----------------------TKTTDETAPIPPGLLKKYIGYANRNVIPQ-LSPEAAE AIEDFYVGLRKR-----A----EGGAAP--VPITARQLESLVRLAEARAKMALRKNVTKE DGQAAVALMTASLQGV-ALDVETG-ELDIDRLVSQES---ASQRSARTAIINTLK-EMET ----DGS---E---SEVELLQRLEVK-GL-PRE--RAEAIIARLV-EEGAVYSPKGEGTI RLPPKS---- ;Replicative DNA helicase Mcm n=18 Tax=TACK group TaxID=1783275 RepID=A1RXH4_THEPD 4TACK_group__UniRef50_A1RXH4 -------------------------------------MVVTQAIPLTERITEFL--KRFT VD--GREK-YRDAIRRMSIER------SIS-LVIDF-DDLLLF-D--K---E--LADILL -----ERPHDFLDAASKAIMEVLKI------ENPDYAKEVGY----------VHARIR-- --RP--P--E-IVHLKIRNIR--ARHLGRLVAVEGIVTKISPVKQELVEGVFK--CKT-- CGT---ELTV---P------QGPE--GLTK-P-TTCP--------VC--SEN--GVKSAG -----------FVLLP------EKSKFVDLQKFVLQEKPEELPPGQLPRSIEVLV-REDL VD-----VVRPGDRATVVGFLRMEE--DKKLVK----NAPP-IFHAYLEANYVEVSA--K ENLDVEITPEDEKKILELSRREDLEEIIINSIAPSIYG--YKEIKTAIALLLFGGV-PKI HPDG-IRVRGDIHILLIGDPGTAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLRYVAS-IAPRGL YTSGKGASAAGLTAAVVKE-KNS-GE-FYLEAGALVLADGGVACIDEFDKMEAKDRVSIH EAMEQQTVSIAKAGIVATLNARASILAAANPAFGRYLPG-RNISENID---LPVTILSRF DLIFVVRDTPNAERDRELAQYVVDFH-----GET-------------------------- ------------------------YPVSLEKVLDAQTLKKYIAYARRHVRPR-LSPEAKS KIVEYYVNMRKK-----S----EDASSP--IAITPRQLEALIRLSEAHARMHLRDVVTAR DAEVAISLMEYFLRNV-GIDTQTM-TIDIDTIMTGQP---KSQREKLIAVLDTVK-NLVR ----QNNG--E-PIKEEDLYSELEKN-GI-DRN--FARKAIEKLL-EQGELMQPSP-GRI SVVSL----- ;Minichromosome maintenance protein MCM n=10 Tax=Archaea TaxID=2157 RepID=A0A150IYU3_9EURY 5Archaea__UniRef50_A0A150IYU3 --------------------------------------MKYSYEEVIDRFKEFY--EA-Y PD-VSEPK-YKKLIDKMKMEG------KSS-LYIDF-DDVIDF-D--F---D--LSEQIL -----KEPEQILTGPNAALKEVYGA-----------ETDKR-----------LTARFV-- --DL--PPTE---KIDIRDIR--AIHINKFIQVEGVVRRTTEVKPEVIEAVFS--CER-- CGE---YLTI-MQD--------SP--SFKT-P-VTCSNP------AC--GRN--G-P--- -----------FKLVK------AYSKFVDWQNIKIQEKPEKLKGGRLPWIMDCII-KDDI VD-----TAQAGNVVNIVGILKTVQ--ENWPKS---GGKKT-TFNKSIEVNSIGIKE--K DIQDLELSEEDEEKILELASDPKICENITNSIAPSIFG--NQHVKYAVALQMFSSE-ARL LHDG-TRIRGDSHILLVGDPGVAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQILKYINL-VAPRSI YTSGKGTSAAGLTAAVIRD-EGS-GS-FALEAGALVIADNGIACIDEIDKMSNEDRSSIH EAMEQQTISIAKAGIIATLNARASILAAANPKRGRFDSY-KPLGEQID---LLPTLLSRF DLIFILTDKPKESDDKKIAEHILKLH----SNEK-------------------------- --------------------------DSIIPILETEDIRKYAIYSKKTIKEITLTDDAKN RLLEFYVSIRKK-----G----EEKNTP--IPITARQLESLIRLSEARARMRLSDKVMVE DVEDIIKLYMKSIEEI-GKDPETG-EIDIDMIMTGRP---KSQRDKITVIMDIIS-NLDK ----KSNN--E-GALTSEVYEEARAE-NI-SDS--FTRKIIDELK-QKGDVYEPRP-DRL KLTLL----- ;Putative ATPase involved in replication control, Cdc46/Mcm family n=72 RepID=A0A0F7IIB4_9EURY 6_UniRef50_A0A0F7IIB4 ----------------------------------------MTMLSSPNVWREFF--QN-- -Y-------YERELNKIAGKISTGDGTEKS-IYVDVLSHLALF----R---EGVLAEELF -----NYPDQVIEDAKNGISLTDNI------------YDVKLEN--------CTPRFV-- --NL--PVSR---RTLIRDLR--AEHISRFISIEGIVRKVTEVRPKIVEAAFV--CSH-- CGK---KVRV-YQE--------ES--KIKT-P-YECP--------AC--KSK--R----- -----------FVFLP------EESVLVDSQRIKIQEYPENLKGGEQPQSIDVYL-EGDI TG-----IVNPGDRVVINGIVRANP---RGQGQ----KKLV-HMDLYIEGNSIEILQ--Q EYEEFEITEEDKKRILELSEDERIYEKIIKSIAPSIYG--YEDIKLAIALQLFGGV-PKR LPDG-TEIRGDIHILLVGDPGVAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLRYVHR-IAPRSV YTTGKGTTTAGLTATAVRD-EVD-GR-WTLEAGALVLADKGIALVDEIDKMRPEDRSALH EAMEQQTISVAKAGINAVLKARCALLGAANPKYGRFDRY-SPIAEQIN---LSPTLMSRF DLIFVLTDDPDPARDTELAKHILQTH---KLGEKL-E----------------------K MRN-VASEYTR--------QSLEGEIQKVVPVIDPDLLRKYIAYAKRTVFPV-LTDEAEK RIIEFYVGMRSK----------AKEDSP--VPVTARQLEALIRLAEASARIRLSDRIELE DVERVIRIIRKSLEQI-ALDPETG-EIDIDYAFSGTS---KSQRDKIMTIKRIVE-ELEK ----EYE---K-GVPEEVIFEEAEKQ-GI-DKL--KTRDLLIKMR-EKGELYCPRP-DHY RVVHNY---- ;Replicative DNA helicase Mcm n=33 Tax=Archaea TaxID=2157 RepID=E8R8R1_DESM0 7Archaea__UniRef50_E8R8R1 ------------------------------MSRESSLETGLRGAELTEAFKKFI--DT-Y RSKEGLRK-YEERIGQ-MVGMG-----QRS-LIVDF-TDLIGY-S--R---E--LANTLI -----DRPDEALESFSDAIRSIVER------DYPEYARKAV--K--------FYPRLR-- --NP--P--E---TLRIRDIS--SDYIGKLIAIEGIVTRVTRIDARIVKATYR--HAD-- PETGVHEFHY---P--EEGEM-GE--RLER-P-QLCP--------VC--GKP--G----- -------R---FELIP------EKSVFIDWQKIVVQEKPEEVPGGQIPRSIEVVL-TGDI VD-----AARPGDRVVVIGILRVAP-VTSIDKR----GPRA-VFSFYIDANNVEVQE--K VLEEIEITKEDEERIRELARDPWIREKIIASIAPGIYG--YWDIKEAIALLLLGGV-PKI LQDG-TRIRGDIHVLLVGDPGTAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLQFTSR-LAPRGL YTSGKGSTAAGLTATVLRD-KAT-GE-YYLEAGALVIADGGVACIDEIDKMRDEDRSAIH EALEQQTVSIAKAGIVARLNARASVLAAGNPKDGRYDPT-KPISKNID---LPPTILSRF DLIFTIKDLPNPEQDRKLARYVLGVH-----SDV-------------------------- --------------------------EKTRPLIDLQLLKKYISYARRYVHPQ-LTPEAAK LIEEFYVSMRKS-------SIPSDPTRPVAIAITPRQLEALVRLTEAHARLSLKSKATLE DAEEAIRLMLVMLTKI-GIDVESG-MIDIDVIESGVS---ASRREKKRKFREFLF-SILE ----EVS-----EISVSEVIKRAREK-GF-ERE--FVQEEIKDML-RSGEIYEPKV-GYI AKA------- ;MCM domain-containing protein n=6 Tax=unclassified Candidatus Bathyarchaeota TaxID=1700837 RepID=A0A1F5DSG1_9ARCH 8unclassified_Candidatus_Bathyarchaeota__UniRef50_A0A1F5DSG1 ---------------------------------------MAKQVSHEEVFTRFI--ED-F RNPEGVLK-YEQNIQE-MPIKG-----VSS-LIVDF-NDVYNY-D--M---E--LAADVI -----NDPDKILELFSRVVYDKLRQ------RDLVWAEAQK--K--------IHVRFR-- --AL--P--S---VTQLRRIG--SEHISRLVMVQGIIVRASATTPQVMKAVFR--CSN-- CNE---LNYV---E--QD----GE--TLKT-P-IKCE--------HC--DSK--T----- -------R---FDLVP------KLSVFMDSQRITIQERPEDLPPGQLPRSLHVDL-KDDI VD-----QARPGDRITLVGSVNLLQ---RFGRG----GQLR-IFDMVMEASHLEVSG--R ESEMTDISPADEDKIKEIAQDPWVHRRLLQSIAPSIFG--LENIKESILYLLFGGL-SKE LPD--VRIRGDINVLLVGDPGTGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLQFAAK-IAPRGL MTTGRGSTAAGLTAAVVKE-GGT-GN-FILEAGALVLSDQGICCIDEIDKMREEDRGAIH PAMEQQIVPIAKGGIVATLNARTSILAAANPTLGRYNPY-QTIGQNIN---LPVTILSRF DVIFVIKDVPDAEKDATMADHILGLH--RAAGST-------------------------- ----------------------------ITSPIDPELFRKYISYAKTRVRPI-LNEEVIT RFKDFYVKMRTA-SIE------GGEASA--VSITARQLESLVRLAEARAKAHLRSEVTKE DAEAVITLMQTSLEQV-GIDVSTG-QIDIDILYTGKP---RSLQTQLQKVLAKIV-ELER -----TG-----PVKDDDLYEALAEE-GI-NRS--EAAKLISTLM-RDGTIFSPRP-GTY RRTS------ ;MCM domain-containing protein n=5 Tax=Thermococcaceae TaxID=2259 RepID=A0A075LT46_9EURY 9Thermococcaceae__UniRef50_A0A075LT46 ----------------------------------------MEKEEMIHGFIEFL--RS-Y ADSKGNKI-YVNKIKDLLTVTP-----KKS-IAIDW-SHLNAF-N--P---P--LAQELM -----DNPEEVILAAKDALRIILSE-----------DFDEEELK--------INPRFY-- --NL--P--H---TLLVKELG--AEHINRLIQVEGIITRVSEVKPFVQKSVFV--CKD-- CGN--EMTRL--QR------P-YS--QMVK-P-PRCE--------NC--GSR--N----- -----------LELDV------EKSSFMNLQTFRLQDRPESLKGGQMPRFVDAIL-LDDL VD-----VALPGDRVIATGVLRIIM----ESRE-----KRP-IFKKILEVNHIEQIS--K DVEELEISPEDEQKIRELAKRPDVIDAIVGSIAPAIWG--HKEVKKGIALALFGGV-HRQ LPDG-TKLRGESHVLLVGDPGVAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQILRYVAN-LAPRAI YTSGKSSSAAGLTAAAVRD-ELT-GS-WVLEAGVLVLADMGVALIDEFDKMSDRDRSAIH EALEQQSISISKAGITATLNSRTTVIAAANPKYGRFNRA-KPLPEQLD---LPPTLLSRF DLIFVLLDEPDENIDSDIATHILKVR----RGEA-------------------------- --------------------------EAVAPKVPYDLLKKYIAYARKNIHPV-LSKEAMD EIKRYYIRMRKR-AKVGNS---EEGVKP--MPITARQLEALIRLSEAHARMRLSDVVTRE DAKEAIAIMEYALKQV-AMD-EEG-MLDISILEVGKS---SKQINKIERMVSIIK-RLEN ----KNE---W-GAPIDDIISEAVES-GM-KKD--EARKLIERLF-NEGQIYSPRD-GYY RVA------- ;Putative ATPase involved in replication control, Cdc46/Mcm family n=28 Tax=Archaea TaxID=2157 RepID=H6QD60_PYROT 10Archaea__UniRef50_H6QD60 ------------------------------------MSLEAELDLLRDKIRELI--TT-N EK-------ISDEIINIIIQR------KRS-LEVDF-HDILMF-D--K---S--LADLVV -----ERPRQVLAEADKVVREVVEE------KDPETARMLKR----------FYLRVR-- --GS--P--L---AVPLRKLR--SEYIGRLIKIEGIITRLTPPKHFLHKALYR--CTQ-- CGY---EIEL--MQ------E-LE--RHVEPP-AKCP--------RCGASKS-------- -----------FTLVT------ELSQYIDWQKAIVQERPEDLPPGQMPRNVEVVL-LDDL VD-----TVKPGDIVSLTGVVDLTL---SELKK----GRPP-IVTSYIQGVHVETMN--K ELVE-EITKEDEQKILEISRRPDVRELIVRSIAPSIYG--YEEIKEAVACLLFGGN-EIV YPDG-VRVRGEINILLIGDPGTAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLKFVAK-IAPRAV YTTGKGSSAAGLTAAVVRD-KLT-GE-FYLEAGALVLADKGIAVIDEIDKMDAKDRVALH EAMEQNTVSISKAGIVATLNARAAVLAAANPAFGRYLPN-RTVAENID---LPVSLLSRF DLIFVIRDEPREDFDSAVAGHILELH----SGKTP------------------------- --------------------------EAFRDVLRPDFLRKYIMYARRYVRPV-LSEEAKE RIKAFYLEMRRR---------YQGPGTA--IAITARQLEALIRLTTAEAKMRLSPIATAE DAERAIRLYLAFLKSV-GIDIESG-AIDIDAIITGVP---ASRREAYIKVVELLK-KLEE ---AERG-----PVKIDTLKAEAEKI-GI-PPA--EVQRIVDLLI-RNGEAYTPRP-GYI KRVT------ ;MCM domain-containing protein n=49 Tax=cellular organisms TaxID=131567 RepID=A0A151BJE8_9ARCH 11cellular_organisms__UniRef50_A0A151BJE8 -------------------------------------MTELLEEDPQERFQNFF--KS-- ------DK-YRQRISQ-MALNG-----TTS-IVIDL-EDLLKA----YL--D--LPEKII -----EKPDEYLRYANRAAFNQLHI------QEPEYAERIRDVG--------VTVRVR-- --GL--L--S---PTPIRVLG--SEHIGRLVVLEGIITRATTVMPLVTKAAFR--CKR-- CGK---VQYV---E------Q-SG--TFLTAP-SRCNEPT------C--GRT--G-P--- -----------FEFLQ------EESEFIDSQEIRVQEYPEDLPPGQTPRSLDVRLVGKDI VN-----VARPGDRVRIVGVVRAES---STMPR---AGKLR-TFTLHIDANFVESAG--R ESEVLSISPEEEEEILKLSKDPWIHRKIIRSIAPSIYG--YEHIKEAIMHLLFGGV-QKN LPD--ITIRGELNVLMIGDPGTAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLRYVQR-IAPRGL YTSGRGTTAAGLTAAVLPT-KAG-G--MSLEAGALVLADKGIACIDEIDKMRKEDRVAIH EAMEQHTISIAKGGIVATLNARAAILAAANPALGRYDPY-RTVAENIS---LPVTILSRF DLIFVMRDIPERERDVSMTDHILKLH---MRGAPP------------------------- ----------------------------EEAPIPPDLLRKYISYAR-NIKPV-LTPEALE RLKEFYLAMRSA-----S----EAEGAP--IAITARQLESLIRVAEARARAALRREVLAE DAEAAIALMRRSLKEV-GIDVSSG-KFDIDIIMTGKP---KSLRDKLRALLSLLA-EMEK ----ETG-----MVRRSDLIESLNREFNI-PQE--EAERLISQLL-REGTIYEPRK-GYL KRI------- ;Minichromosome maintenance protein MCM n=1 Tax=Candidatus Heimdallarchaeota archaeon LC_3 TaxID=1841598 RepID=A0A1Q9NP09_9ARCH 12Candidatus_Heimdallarchaeota_archaeon_LC_3__UniRef50_A0A1Q9NP09 --------------------------------------------MNEEQFKSFF--YE-F RDESGQPI-YDLKIDKLIQNK------QRS-LEVSI-TDMQNF-EILNPEVE--LTNPLL FPDAINGPKNAIKEAVKALKTIIRE------KDEEYLRLIKHR---------INIRFH-- ---LAPP--E-TIQEKLREIR--SAQIGKLIQTNAIITKASEVKPLIETGRFE--CLT-- CRS---LIDR-YFS--------DG--EYQP-P-VFCEIQQADGS-NC--SGR--S----- -----------FKLLK------DDSDFVDIQRIVLQERPEDLPAGRMPENFVAYL-RDDL VD-----TVRPGDRVTIVGMLDTRP--DRKLAR----GQLA-IFSKFLETIHVEKES--E ELVELEISQEDEEAILELSRDVMVLEKIRESIAPMIFG--FTEEKEAISYLLFGGT-EKK LSEG-LKIRGESNILLIGDPGVGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQILRSVAE-IVPRKI YTSGRGASAAGLTAAVMRD-PDT-NE-MTLEAGAVVLADKGFAFIDEFDKMKREDRSALH EAMEHHTVSIAKAGIIATLNARTSILAAANPRDGRWIKD-RTPMNNMN---LPQTIISRF DLIFPMVDEPNAIEDEKKAAHILSMH---QQGRF-------------------------- ----------------------------DEPPIDIELLRKYIEFARKNIIPK-LSPEAKD QLLDFYLDLRSR-----SGLNEEAGGRPSSVSITPRQLEALVRLSEARAKMALRDIVTRE DAERVIKLFKFSYDKI-AMD-ETG-AYDVDRASGGVG---AQTRNDLGKLKDLIL-KMSR ----ENED--G-DVKASDLKIKSTAELDI-DPR--KYDELMENLS-REGEIYEPRP-GVI RLSSY----- ;Minichromosome maintenance protein MCM n=69 Tax=Methanobacteriales TaxID=2158 RepID=U6EEF4_9EURY 13Methanobacteriales__UniRef50_U6EEF4 ---------------------------------METESTTDKTKNPVAKFEEFF--ST-- -K-------YKDTVYEALEKYPE----DRS-VVVDY-VELEMF-D--P---D--LADLLI -----EKPEEVIKAASKSVQNIDPL-----------RKNAE-----------LNIRFE-- --NV--R--N---NIPLRYLR--SKYIGKFVAVDGIVRKTDEIRPRIRKAIFE--CRS-- CMR---LHEV--QQ------K-SN--VITE-P-ALCQ--------EC--GGR--S----- -----------FRILQ------EESEFLDTQTTKVQEPLENLSGGEQPRQINVVL-EDDL VD-----TVTPGDVVRITGTMKTVR-------D----EKTK-RFHNYIYGNYISALE--Q EFEELDISPEDEEKIKELAKDPDVYNKIINSTAPSIKG--YREVKEAIALQLFGGT-AKE LDDK-TRIRGDIHILIVGDPGIGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQMLKYVSK-LAPRGI YTSGKGTSGVGLTAAAVRD-EFG-G--WSLEAGALVLGDKGNVCVDELDKMRPEDRSAIH EALEQQTISIAKAGIMATLNSRCSVLAAANPKFGRFDRY-KSIAEQIN---LPSTILSRF DLIFVVEDKPDVEKDSALASHILNTH----RDTA-------------------------- ----------------------------VPYEIDPELLRKYIAYARREIKPH-LTNEAMD VLREFYVGMRGG-----A----SDEDSP--VPITARQLEALVRLAEASTKIRLGHEVTAE DAKRAVSLQEKCLKQV-GYDPETG-KVDIDKVEGRTP---KSDRDKIRVVQEIIK-ELEE ----EYG---G-RAPTNILITEMRDRYNM-SEE--KVEDLIRQLK-RKGIIYEPQQ-GYL RVA------- ;MCM domain-containing protein n=15 Tax=Archaea TaxID=2157 RepID=A0A2R7Y165_9ARCH 14Archaea__UniRef50_A0A2R7Y165 -------------------------MAILRLPSPARGGCGHVSVPLEEKLVDFF--KA-- ------EK-YRALLAR-AALTN-----QRS-IPVDF-SDLLAF-D--E---E--ISNRIV -----NEPLRYLPALSRAAYKQLQI------ESPEYAARIT--N--------FYARVH-- --NL--P--E---VTPIREIR--SAHLRKLIMVDGIVVRATVVKPMLDVGTFQ--CRY-- CGE---KYRI---P--QD----NA--PRLRQP-ERCV---SP---QC--RGK--R-P--- -------S---FELIQ------EESEFVDYQIIGIQEKPEDLPPGQLPRIVEVRL-RDDL VD-----RARPGDRVLITSILLSLQ---ERAGE----APLR-TFRSYLDAVWVETVS--K EPESLQITPEEEEMFKQMAQDPLIYNKIIDSLAPSIYG--LEHIKEAIMLLLFGGR-TKV FPDG-VKVRGDINILLVGDPGTAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SALLQYVAS-IAPRGL YTSGRGTTAAGLTAAVIRE-QGG-G--MVLEAGATVLADMGVCCIDEIDKMKPEDRVALH EVMAQQTASVAKGGIVATLNARTAILAAANPALGRYDPY-MSFTDNVN---LPVTLLSRF DLIFVLRDEPNPEQDRKVSSHILALH---SMGSP-------------------------- ---------------------------TVVPPIKPEVLKKYIAYAKR-VNPE-LTPGALR ILEDFYLQMRSV----------YEKTST--VTITARQLESLIRLAEARARAALRDKVTEE DAGAVVLLMKRSLQEV-GIDVKTG-KPDIDVIMTGKP---KSVRDKLAVVLNTIK-EFED ----RKG-----VAEEEELKAALLEN-GL-SEP--EINRILSWLI-TEGKVYTPKP-GCY KVA------- ;Replicative DNA helicase Mcm n=6 Tax=Archaeoglobi TaxID=183980 RepID=N0BED9_9EURY 15Archaeoglobi__UniRef50_N0BED9 ---------------------------------------MMFSSP--EAWREFF--ET-- -Y-------YQKELNTLADKILTDGRKEKS-IYVNFLKDLFIFYE--G---R--IAEELL -----EYPDTVLEHASKGLELSYNI------------HDVRLEN--------CKARIV-- --NL--P--Q-TRRILIRDLR--SEHVSKFVAVEGIVRKVTEVRPKIVKASFI--CLS-- CGN---EVFV---V--Q---D-DN--QLKQ-P-YECK----T----C--NTR--G-R--- -----------FVFNP------DNSIKVDSQRIKIQEYPENLRGGEQPQTIDVFL-EGDL TG-----KINPGDRVVINGIVRART---RGYGS----RKTP-YMDIFIEGNSIEVLQ--Q EYEEFEITQEDIEKIMELSEDPDLYKKITDSVAPVIYG--YDKIKLAIALQLFGGV-PKK LPDG-TEIRGDIHILLVGDPGVAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQMLRYVHR-IAPRSV YTTGKGTTSAGLTATATRD-EVD-GR-WTLEAGALVLADKGIALVDEIDKMRAEDRSALH EAMEQQTISVAKAGINAMLRSRCALLGAANPKYGRFDLY-SPLVEQID---LSPTLLSRF DLIFIMTDQPNPDHDRRLAEHILKTH---QIGEKL-E----------------------M MKH---LSIEA--------AEYRNEYKNIEPKIDPQLLRKYIAYAKRTVFPV-LTKDAMD RIIEYYVNLRNS----------SKESS---VTITARQLEALIRLAEASARLRLSDEVTVE DVNRVIDVVEASLKQI-ATNPETG-EIDIDYGLTGTS---KTQRDRILTIKKIVE-ELEK --LDDYR---K-GVPEDEIIKRAVEK-GI-DEM--RAKDVLHKLR-EKGELYSPRP-NLY RIVHYT---- ;Minichromosome maintenance protein MCM n=26 Tax=Sulfolobaceae TaxID=118883 RepID=MCM_SACS2 16Sulfolobaceae__UniRef50_Q9UXG1 -------------------------------MEIPSK-----QIDYRDVFIEFL--TT-F KGNNNQNK-YIERINE-LVAYR-----KKS-LIIEF-SDVLSF-N--E---N--LAYEII -----NNTKIILPILEGALYDHILQ------LDPTYQRDIE--K--------VHVRIV-- --GI--P--R---VIELRKIR--STDIGKLITIDGILVKVTPVKERIYKATYKHIHPD-- CMQ---EFEW---P--EDEEM-PE--VLEM-P-TICP--------KC--GKP--G----- -------Q---FRLIP------EKTKLIDWQKAVIQERPEEVPSGQLPRQLEIIL-EDDL VD-----SARPGDRVKVTGILDIKQ--DSPVKR----GSRA-VFDIYMKVSSIEVSQ--K VLDEVIISEEDEKKIKDLAKDPWIRDRIISSIAPSIYG--HWELKEALALALFGGV-PKV LED--TRIRGDIHILIIGDPGTAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQMLQFISR-VAPRAV YTTGKGSTAAGLTAAVVRE-KGT-GE-YYLEAGALVLADGGIAVIDEIDKMRDEDRVAIH EAMEQQTVSIAKAGIVAKLNARAAVIAAGNPKFGRYISE-RPVSDNIN---LPPTILSRF DLIFILKDQPG-EQDRELANYILDVH----SGKS-------------------------- ----------------------------TKNIIDIDTLRKYIAYARKYVTPK-ITSEAKN LITDFFVEMRKK-----SS---ETPDSP--ILITPRQLEALIRISEAYAKMALKAEVTRE DAERAINIMRLFLESV-GVDMESG-KIDIDTIMTGKP---KSAREKMMKIIEIID-SLAV ----SSE-----CAKVKDILKEAQQV-GI-EKS--NIEKLLTDMR-KSGIIYEAKP-ECY KKV------- ;MCM family protein n=3 Tax=Candidatus Korarchaeota TaxID=51967 RepID=B1L6L9_KORCO 17Candidatus_Korarchaeota__UniRef50_B1L6L9 ---------------------------------MVEKSPLMSSEELVEKYKSFI--RY-Y RDENNEPI-YQKALAQLIEEQ------RRS-LSVNW-YHLYNF-N--PDFRE--IAEDIV -----MNPSLHISAGSSAIKELVMELMPMTEEFRIYSEGD------------FHLRFY-- --NV--P--T---KASFRDLT--KFSIGRLIEIEGIITRVSDIYDKLVRASFI--CTN-- CGR---IEEI---D------IIGE--KLRV-L-EKCP--------EC--GAP-------- -----------MKLDH------EMSKFIRWRSVRIQERPEDLPPGMMPEHVDGIL-TDDI VD-----DVKPGDRVRVTGIIRIKP---ARRDE----GREGLIYKRYLEIIHVEVPN--R VYEKLEITPEDEEEILKLSEREDLEELIVKSIAPSVFG--WADVKRAIAYALFGGS-TKI LADG-SKVRGEINVLLVGDPGVAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLKYTAQ-LAPRGL YTTGKGSTAAGLTAAVVRD-SAT-GG-WTLEAGALVLADMGVACIDEFDKMSEDDRRSIH EAMEQQTISIAKAGIVATLNARTTIIAAANPKKGKYDDY-VTVAENIN---LPPTILSRF DLVFIMKDRPGVESDSMVAEHILITR----MGRNPEA----------------------- -----------------------------KPPIDPNLLKKYIAYAKQNIDPI-LTDEAAE RIKNYYVDVRGR-----GIKESEEGIVQDLISITPRQLEALIRLSEARARMHLRREVTAE DAEMAINLMEITLKGA-AYDIVSG-HFDITGWMTGIS---FPEVKRREVVFQIIK-QLAE ----GSED--G-LVDRDVVVRMAAERLNL-KGKEYVIEDILRKLN-EDGLIIFPPG-GKI RLI------- ;AAA family ATPase n=14 Tax=Halobacteriales TaxID=2235 RepID=A0A2R6GIE6_9EURY 18Halobacteriales__UniRef50_A0A2R6GIE6 -------------------------------------MATAENQELVERFEEFY--RS-- -Y-------YRDEIGELAQGYPGE---RRS-LHVDW-EDLYRF-D--Q---H--LADDFL -----SQPEQLQEYAEEALRLYDLP------------VDVSLGQ--------AHVRVY-- --NL--P--E---TTGIRDIR--SQHVNTLVSVKGIVRKATSVRPKIREAAFE--CQR-- CGT---LTRV---P--Q---P-DS--DFQE-P-HECQ--------GC--ERQ--G-P--- -----------FRINF------DQSEFVDSQQLRVQESPEGLRGGDTPESIDVHV-EDDL TG-----EVSPGDHVKVTGVLHLEQ---QGSNN----DKSP-VFDVYMDGMSIEIED--E EFEEMDITEADKRRIVELSSDEHIYERMVDSMAPSIYG--YREEKLAIILQLFSGV-TKH LPDG-SRTRGDLHILLIGDPGTGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLQYIRN-IAPRSV YTSGKGSSAAGLTAAAVRD-DFGDGQQWSLEAGALVLADKGIAAVDELDKMNPDDRSAMH EGLEQQSISVSKAGINATLKSRCSLLGAANPKYGRFDQY-EPIAEQID---LEPALISRF DLIFTVTDQPDEEEDKRLAEHIIQTN---YAGELN-T----------------------Q RTELAAANVSE--------EQVENVTDTVAPDIDADLLRKYVAYAKRSCFPT-MTEEAKE AIRDFYVNLRAK-----G----EGEDAP--VPVTARKLEALVRLAEASARIRLSDTVERE DADRVIDIVRSCLQDI-GVDPETG-QFDADVVETGTS---KSQRDRIKNLKQLIS-DIEE ----DHD---D-GAPVDEVLERADEI-GM-EPS--KAEHEIDKLK-QKGEVYEPRT-DYL RTT------- ;Replicative DNA helicase _Mcm, cdc21_ n=3 Tax=Thaumarchaeota TaxID=651137 RepID=A0A075FIL5_9ARCH 19Thaumarchaeota__UniRef50_A0A075FIL5 -----------------------------------MEQSIGTHSSWDDTLVRFI--KN-F KDKSNILK-YQEALSQ-MVYHN-----SKS-LIVDY-EDLLIF-D--D---D--LSTILI -----ERPDEVLSEFNSATYKSLYS------VHPEYAESIK--N------D-IQVRLR-- --SL--P--E---QVPLRDIS--SKNLHRLSSVEGLVVRTSELKPLATSAAFA--CTK-- CGE---SNVI---Q--QV----TP--LLVK-P-SSCIRA------DC--SET--K----- -------N---FTFDE------KQSSYQDYQLIRIQELPEELPPGQLPQSSDVHL-TGDM VN-----IARPGDRLNLTGIVRIDQ---PESRG----NEASSIFRSKIEGNYIDIES--K GPEDVELTKDEEELILDFAKDLDAYPKLIQSIAPNIQG--LESQKEAVLLMLIGAP-NKT TEDG-SSIRGDINILFVGDPGTAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SELLKYASR-LAPRGL YASGKGSTAAGLTAAVVRE-R-T-GM-MMLEAGTVVLADKGIACIDEFDKMRNEDRTALH EAMEQQTVSVAKGGINATLNARTAVLAAANPELGRYDNY-KTFNDQIN---IGAALLTRF DLIFAIKDTPNVVRDEKLAQHILAIH---EKGKI-------------------------- ---------------------------TVDVPLEFDLLKKYISYAKNFI-PT-LSPEAKK LIQDYYVQTRQK--PAKG----DGEHDG--IPITPRALEGMVRLASARARSLFRDIVTEE DAEFARNLVRKMYESV-GTDPETG-EVDPGIFY-GKP---VSQRSMLETCMNIFE-ELQK ----ESSK--Q-LVDKDEFIQKLIDTGKF-TST--EARKYFKNMS-DSGQIYNVQD-NLY RKVN------ ;MCM domain-containing protein n=10 Tax=TACK group TaxID=1783275 RepID=A0A1Q7MMI6_9CREN 20TACK_group__UniRef50_A0A1Q7MMI6 ------------------------------------MLAPTETALPENVFQDFF--RA-Y QADPVGSK-YRKRLAEVAVNNG------RS-LVIDF-DDLIAF-D--P---V--LARNVV -----NHPDDFFVHAGSAATSQMRV------EDPEYAEQVGR----------IIVRFR-- --RL--P--E---KRALRKIG--AEDLMKLALVEGIVVRTGQVRPMIVKAVFR--CRK-- CGE---LSRQ---D------Q-TG--DLLRGPGPICA--------SC---KQQSG----- -----------WDLIE------DQCVFKNTQEARVQERPEDLPPGMLPRYLDVRL-DDDL VD-----TARPGDRVALTSVVRAEK--QYAGEK----GKLR-TFNLYLEANFVDVVG--K ETEIVEITLEDEKKIIEASKHPFVHRNLIMSLAPSIYG--YDEIKEGILYLLFAGV-AKR LPDG-VNIRGDLNCLIVGDPGTAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLQYVSR-IAPRGL YTSGRGTTAAGLTAAVLRE-KTG-G--MVLEAGALVLADKGVACIDELDKMRPDDRVAIH EALEQQTVSVAKGGIVATLNARAAVLAAANPSLGRYEPH-RNINENIN---LPVTILSRF DLIFLVKDLPDPDSDSEMSSHILQLH----RARH-------------------------- --------------------------GSEEAPFQPDFLRKYISYAKR-IIPV-LTPEAVK ELQDFYLKMRGT----------TGREAA--VAITPRQLEALVRLSEARARAFLRDQVTVE DAKSAVKIMTYALLDV-GVDVKTG-KIDIDTIMTGRP---ATVRDTLGRVIDIVR-ELER ----ETGD-----VDEKILIAAIVDKNKV-TDG--EARRFVGQLI-KEGMLYSPKE-GRL KRTSS----- ;Mcm2 DNA replication licensing factor n=34 Tax=Euryarchaeota TaxID=28890 RepID=Q8TSW4_METAC 21Euryarchaeota__UniRef50_Q8TSW4 --------------------------------------MTETESKWGEKLKKFF--KD-- -Y-------YWNEILQLANEYPD----QRS-LEVDF-TDMEKF-D--R---E--LSKELL -----EHPGELIFAAEAALKEIDLP------------VEKSLEQ--------AHVRVI-- --KI--P--N---RIPIRELR--SKHLSRFVAIEGMIRKATEVRPRITEAAFQ--CLR-- CGH---LTLV-EQN--------SF--KFEE-PYAGCEGD------NC--GKK--G-P--- -----------FKVSI------EDSTFIDAQKLQIQESPENLKGGSQPQSLEVDT-EDDL TG-----NITPGDRVIINGILKSRQ---RALKD----GKST-FYDLVLEANSIERLD--K DFDELEITPEDEEQILELSRDPAIYEKIIGSIAPSIYG--YEDIKEALALQLFSGV-VKN LPDG-ARIRGDIHMMLVGDPGIAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLRYVVK-LSPRGV FASGRSASASGLTAAAVKD-DMNDGR-WTIEGGALVMADMGIAAVDEMDKMKTEDKSALH EAMEQQTISVAKAGIIATLKSRCALLGAANPKYGRFDRY-EGLAEQIS---MPPALLSRF DLIFVLLDTPNHALDSRIANHILQSH---YAGELS-E----------------------Q RLKLPGSKVTE--------DFVDAELEVIEPVIQAEIMRKYVAYARKNVYPV-MEEDARQ HLIDFYTGLRKS-----G----EGKNTP--VPVTARQLEALVRLSEASARIRLSNVVTLE DAKRTIRITMNCLKNV-GVDPETG-ALDADILASGTS---MSQRNKIKLLKDIIK-KVCE ----RHTG--A-KAPLEEVYAEAENEHGI-DRG--HAEEYIKKMK-QRGDILSPDQ-NHI RLIN------ ;MCM domain-containing protein n=9 RepID=A0A0F9UKX3_9ZZZZ 22_UniRef50_A0A0F9UKX3 --------------------------------MTTPFTNSAVPLNKIQKLEDFY--RL-F QERPGEYK-YLEQINN-VFSKG-----GNA-LIILY-EDLLAY-D--P---Q--IADLLS -----NDPQSLLEDAVEAFKNILKF------QGAVL-TNKD-----------YFVRIS-T RDKLC-P--L---FCSLRGLR--AKNIDKLIYTKGILVRCSSIRPKLLKAKFE--CAV-- CGS---QFEV--IQ------L-TS--RIKW-P-NFCTDK------RC--KAKTQSD---- -----------FRLIS------KSSEFIDWQSITLQEIPEDLPPGRIPRSVQAIL-THDL VD-----IVKPGDRVKIMGLYKSVL---AQSTK----SFNSTLFKTFIEVNLIDPED--K SDQLIELSIEDKKKIEELSNEPMIQKKIARSIGPNIYG--REQLKMACALSLFGGT-RRK KPGG-GYKRGDLHFLVVGDPGTGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SEILKGAVE-VSPRGL YTSGKGSTGVGLTAAVIKE-SET-GQ-MNLEAGVVVLANGGVAAIDEFDKMDTADRSALH EAMEQQTVSIAKAGIVATLKAQTAIIAAANPQYGRYDRY-KTPTQNIR---LPPSLLSRF DLIFIVVDRPNKSEDAQMAEFILKNA--MTKPEEDFD----------------------- ------------------------NENDTITPISSEFLKKYIKYARRTCHPV-LTDEAKE RIKEFYLGLRGQ---------YESEDAI--ISILARNLDALIRLSEAYAKMALRDNVIKD DVEEVIKLFQRYLKDT-GYDETSG-KIDMDRIFIGES---RSNLNKLESLMNRLK-EIFE ----ENNW--K-SLEKKNVIQILELEENL-DKK--FIENSLGELI-REGTLYEPRS-NFI KFTNNEVI-- ;DNA replication initiator _Cdc21/Cdc54_ n=3 Tax=Nanohaloarchaea TaxID=1051663 RepID=H0AET4_HALSG 23Nanohaloarchaea__UniRef50_H0AET4 ----------------------------------------MDYGEAVTEFEEFF--TE-- -------K-YEQEVLS-AEKQG-----KDS-VIVEF-KDLDMF-K--P---E--ITDYLK -----EEPEKALDAASEGVMAVDIL------KE-E-----------------LNVRIR-- --NM--P--E-EDYVLLKNLR--SEHIGKFVPVEGMIKRASQVKPEVVSAVFE--CTQ-- CGD---RYTK---E--QD----SS--QLKS-P-YKCE---------C--GSK--R----- -------------FDP------VEKNMTDTQIVTLEENPESREGSEQPSSLSVRL-EGDL VDPEFQRKVVPGNVVEVTGIVRERP--IKKNSK---------KFDIYMEANNVEPRQ--Q EFEQLELEEDEIEEIREMASDENIFGRITESIAPSIFG--HDRIKEAIALQLFGGV-RKT REDG-VKSRGDLHILLIGEPGTGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLKFAGE-LAPKGR YVVGKSSTGAGLTASVVKE-EST-GE-FSLEAGAVVLAHKGMAAIDEIDKMSVEDRSSLH EAMEQQQISVSKANIQATLNAQTSILAAGNPKLGRFDPY-EPIPEQIN---IGDTLLSRF DFIFPVKDEPDQDRDNKLANQILANH-----REP-------------------------- --------------------------EDQDAEISQEKLRKYVAYAKKNVRPD-LTEEASD LIQDFYVSMRSS----------GDEDS---VPITARQLEAMVRIAEASARAQLKDQVEES DAQRAIDILKYTLEQV-GMDPETG-DFDIDRIESGVS---SSQRNRIQTIKHLID-ELAG ----DDG-----SAEIEAVIEAAESE-DI-SSE--KTEEVIEKLK-REGELFEPKQ-GFV QKI------- ;AAA family ATPase n=15 Tax=Archaea TaxID=2157 RepID=A0A257AQB8_9EURY 24Archaea__UniRef50_A0A257AQB8 -----------------------------------------MQDALAEKWEDFL--KR-Y ---------YWDELVELSNSYPE----KRS-LFVKF-IDIDKY-D--S---D--LANMVL -----EEPDAALDTATQALQEIDIP------------TGVTLDE--------ANLRII-- --KL--P--R---KLKIRDVR--SSDIGRLTSLEGLVTKVTEVRPRVAEALFE--CPF-- CGY---QFLV---E--Q---K-GR--QFKE-P-SECE----S----C--DRK--VQH--- -----------FLLLT------ERCKFANSQKIRLQESPEELRGGELPQLLDVNL-EDDI SG-----VVAPGDRVAVTGILRSFQ---RQTQY----GKMP-FFEVYLDGNSLEVKE--E EFEEIEITEADEREILGLKEQPDLYEKLIKSIAPSIYG--YEEIKEAMVLQLFAGI-PKE LPDE-TRVRGDIHVLLVGDPGVAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLTYLVK-LAPRGL YTGGKSSTSAGLTAAAVKD-EFGEGR-WTLEAGALVLADKGIAAVDEIDKMEKRDRDALH EAIEQQTVSIAKAGMMARLNSRCALLAAANPKGGRFDRY-TPISEQIN---MPPTLLSRF DLIFTMLDRPNEELDTRTAKHIIETH---YVGELL-ATPGDRSSGSRREAGSERGERGER AERAERAERAERGERAEREEHFKVAMQRMKPEIAGGLLRKYVAWSKRNVFPV-MSEEAKQ KFLDFYIGLRQP--------SYEDEDAP--VPVTARQLEALIRLGEARARARLSDKITAE DAERVINLVTYCLKRV-FVDPETG-KLDADWVNVGTT---KTRRDRARSIREIIK-ELVK ----EYG---E-EVPIEAVLDAAEEE-GT-ERE--KAEEMIEVMK-REGVLYAPGG-GVV KFVR------ ;AAA family ATPase n=45 RepID=A0A1E7GEI2_9EURY 25_UniRef50_A0A1E7GEI2 --------------------------------------MTETESKWDEKLKRFF--KD-- -Y-------YWNEILQLANEYPD----QRS-LGVDF-TDIEKF-D--R---E--LSKEFL -----DHPGELIEAAEAALKQIDLP------------VEKSLEQ--------AHVRIM-- --KI--P--N---RISIRELR--SKHLSRFVAIEGMIRKATEVRPRITKAAFQ--CLR-- CGH---LTVV--EQ------N-SF--KFEE-PFSGCEND------TC--GKK--G-P--- -----------FKVMI------GDSTFIDAQKLQIQESPENLKGGSQPQSLEIDS-DDDL TG-----NVTPGDRVIINGILKSVQ---RTLKD----GKST-FYDLVLQANSIEHLD--K DYDELEITAEDEEQILELSRDPAIYDKIIGSVAPSIYG--YEDIKEALSLQLFSGV-VKN LPDG-SRIRGDIHVLLVGDPGIAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLRYVVK-LSPRGV FTSGRSASASGLTAAAVKD-DLNDGR-WTIEGGALVMADMGVAAVDEMDKMKAEDKSALH EAMEQQTISIAKAGIIATLKSRCALLGAANPKYGRFDRY-EGIAEQIN---MPPALLSRF DLLFVLLDTPNHALDSKIASHILQSH---YAGELF-E----------------------Q RQKLPSSLITE--------DFVEAEMEVIEPIIDPEIMRKYVAYARKNVFPV-MEGNTRN RLMKFYTDLRKT-----G----EGKDSP--VPVTARQLEALVRLSEASARVRLSNKVTLE DAERTIKIVMNCLKNV-GIDPDTG-ALDADIIASGTS---MSQRNKIKVLRDIIK-KVSE ---RHPGK--E-GAPLEEVYTEAESNHGI-NRT--HAEEYIKKMK-QGGDLLSPDQ-KHI RLVN------ ;Putative ATPase involved in replication control, Cdc46/Mcm family n=21 Tax=Thermoprotei TaxID=183924 RepID=V4K357_9CREN 26Thermoprotei__UniRef50_V4K357 -----------------------------------MSEGVQEQLTVGEKFKEFL--RS-F KD-ATGLK-YMNRVHRMMNLD------MTS-LLVDY-PDLYRH-D--P---E--LAVLLV -----DNPRPVLKQFDDALKEVVAA------EDPDYAKRKGK----------FHVRVQ-- --GL--Y--E---TTKIRDVK--TSHMGRLVQIEGIITRMRPVRSKMVKAAFR--HEKEG CNA---EFLW---PEGEDELI-ED--KIER-P-PACP--------VC--HEA--GGR--- -----------FVLLR------DKSIYIDWQELTLQERPEDVPGGQMPRSIAVEL-TEDL VD-----IARPGDLVTVVGIVEPSP-----VGG----DKSP-LFELRVRANSLRVSE--K VLEEVAITREDEEKILELAKDPWVRERIVASIAPSIYG--HWDLKEAIALQLFSGV-QKV MPDG-TRIRGDIHVLFVGDPGVAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLQSASR-IAPRSV FTSGKGSTAAGLTAAVLKD-PKS-SE-YFLEAGALVLADGGLAVIDEFDKMRPEDRVSIH EAMEQQTVSISKAGIVARLNARAAVLAAGNPKYGLYDPQ-RSFIDNVN---LPPTVLSRF DLIFVVRDLVSKEHDERLARYILDVH-----SDF-------------------------- --------------------------SRFTPEIDPQLLKKYVIYARRYYRPK-LSDEAKE IIQEFFVTMRST-----ALKYGSEGQIP--VPVTARQLEALVRLSEAHARMGLKETVTAE DAEEAIRLMLSFLSSV-GLDIESG-AIDIGIISTGAP---FHTRKLMTVITDTIK-RLSE ----DGRP----CVKHEDLVKEVINITKA-SKE--KAEEAIAKMK-QQGLIIERRP-ECY TVM------- ;Replicative DNA helicase Mcm n=18 Tax=Methanosarcinaceae TaxID=2206 RepID=Q46C52_METBF 27Methanosarcinaceae__UniRef50_Q46C52 --------------------------------------MTEIESKWDEKLKRFF--KD-- -Y-------YWNEILQLANEYPD----QRS-LSVDF-TDIEKF-D--R---E--LSKEFL -----DHPEELIKAAAAALKEIDLP------------VEKSLEE--------AHVRVV-- --RI--P--N---RVPIRELR--SKHLSRFIAIEGMIRKATEVRPRITKAAFE--CLR-- CGY---LTFV--DQ------N-SF--KFEE-PFAGCEGE------NC--GKK--G-P--- -----------FKIRI------EDSTFIDAQKLQIQESPENLKGGSQPQSLEVDS-EDDL TG-----SVTPGDRVIINGILKSRQ---RTLKD----GKST-FYDLVLEANSIEHLD--K DYDELEITAEDEEEILELSRDPEIYGKIVSSVAPSIYG--YEDIKEALVLQLFSGV-VKN LPDG-SRIRGDIHIMLVGDPGIAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLRYVVK-LSPRGV FTSGRSASASGLTAAAVKD-ELNDGR-WTIEGGALVMADMGIAAVDEMDKMKTEDKSALH EAMEQQTISIAKAGIIATLKSRCALLGAANPKYGRFDRY-EGLAEQIS---MPPALLSRF DLIFVLLDTPDHNLDTKIANHILQSH---YAGELF-E----------------------Q KEKLPGSQIKE--------DFVEAEMEVIEPVIQPEIMRKYVAYARKNVFPV-MEEDARA HLINFYTDLRKT-----G----ESKNTP--VPVTARQLEALVRLSEASARVRLSNTVTLE DAKRTIKIMMNCLKNV-GVDPETG-ALDADILASGTS---MSQRNKIKILRDIIK-KVSE ---KHPGA--K--APLEEVYAIAENEHGI-DKI--HAEENIKKMK-QRGDLLSPDQ-NHI RLV------- ;Replicative DNA helicase Mcm n=13 Tax=Stenosarchaea group TaxID=2290931 RepID=A0A1G9PET4_9EURY 28Stenosarchaea_group__UniRef50_A0A1G9PET4 -------------------------------------MAQAQNQELTERFIQFY--RN-- -Y-------YRDAIGQLAQKYPNE---QRS-LYIDY-DDLYRF-D--P---D--LAEDFL -----NQPDQLREYAEEALRLYDLP------------ADVKLGK--------AHVRLR-- --NI--D--R---AVDIRSIRVHDDHIGKLIAVSGIVRKATDVRPKITEAAFE--CQR-- CGT---MTYI---P--Q---S-DG--NFQE-P-HECQ--------GC--ERQ--G-P--- -----------FRVNF------DQSEFIDSQKIRVQESPEGLRGGETPQAIDIDL-EDDI TG-----RVTAGDHVTVTGVLHIEQ---QKSGQ----EKSA-IFDLYMDGMSITVED--E EFEDMEITDEDKQQIIEISNRENIYEDMVASVAPAIYG--YDEEKMAMILQLFSGV-TKH LPDG-SRIRGDLHMLLIGDPGTGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQMLSYIQN-IAPRSV YTSGKGSSSAGLTAAAVRD-DFGDGQQWTLEAGALVLADKGIAAVDELDKMRPEDRSAMH EALEQQKISISKAGINATLKSRCSLLGAANPKYGRFDQY-EPIGEQID---LEPALISRF DLIFTVTDQPDPEHDGKLADHILKTN---YAGELN-T----------------------Q RTHVPTSKFTE--------EEVNSVTEEVAPEIDAELLRKYIAFSKRNCYPT-MTEEAKA AIREFYVDLRAK-----G----ADEDAP--VPVTARKLEALVRLAEASARVRLSDEVSEE DATRVIEIVRSCLQDI-GVDPETG-QFDADVVETGTS---KSQRDRIKTLKQLIS-EIEE ----EFE---E-GAPVDEVLDRADEI-GM-GRD--KAEGEIEKLR-RKGEVYEPKT-DHL RTT------- ;AAA family ATPase n=5 Tax=Archaea TaxID=2157 RepID=A0A3M1DD34_9ARCH 29Archaea__UniRef50_A0A3M1DD34 ----------------------------------------MELNEQILGFQDFF--MQ-- -------E-YHEEILE-RVRTG-----KHF-LVVDF-NRLARF-N--P---D--LASLLL -----DKPEDIIKAAELSLKHFD-L-------------PLK---------EDFFIRFF-- --NL--P--S-TQHVMVRDVR--AKHLGKFIQMDGIVRQKSDVRPQVTSARFE--CPS-- CGN---IIPV---L--QL----EQ--KFRD-P-GMCN--------AC--GRK--G----- ------------RFRL------LSKKLVDAQKIVLEENPEELEGGEQPKRLNVYL-KHDL VSPMTEKQTNPGAKVRVVGIVKEVPI--PLNQG----GQSV-RFDLINEANFIEPLQ--E DYTQIEISKEEEEEILALSRDPAVFAKITESIAPSIYG--MEKVKEALVLQLFGGV-HKE RGEGGVKSRGDIHILLIGDPGAGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLKRISH-VAPKAR FVSGKGASGAGLTASVVRD-EFLRG--WALEAGALVLANRGICCIDELDKMTPEDRSAMH EALEQQTVTISKANIQATLRSETTVLAAANPKLGRFEPR-EILARQIE---LPSTLINRF DLIFPIRDLPEREKDEKLASFILKLH---QSNEE-------------------------- ----------------------------QKGCLSTEFLRKYISYAKQRCKPK-LSDEALE ELKEYYIKMRSS-----GGNDNEAAFQA--IPISARQLEALVRLTEASAKSRLAATATKR DAKIAIDLVHHCLSAI-GLDPETG-KFDIDRIASSIT---ATQRSNIAIIKDIIK-QLEE ----VTG---NKNVSVNDVVREAETK-GI-DAE--TTDEIIEKLK-RSGDIYAPRH-DII SRM------- ;MCM domain-containing protein n=12 RepID=A0A147JXI2_9EURY 30_UniRef50_A0A147JXI2 -----------------------------------------MDQALKEKLEKFL------ ---------HRKEILKELRKLAAAG--QKS-LVVEF-ERLLEV-K--M---E--LAKALL -----DAPNDFLEAADAILTEITKL-------------------------PGMCLRVR-- --GL--D--K---TTVIRKIR--AEQVGKFIQVEGIMTRASEVKPEVKEAVFK--CLR-- CET---LNRV--MQ------I-DE--VFRE-P-LICENPN------C--SRR--G-P--- -----------FKLEV------ESSEFRDWQSIRLQERPEELRGGRMPRQLDCII-KDDF VD-----KAVPGNRVVASGVLRVFQ---EGMQR----QRKT-TFRKILFINHIEVLQ--K GAEETELSPEDEARMKELGKDPWLRNLVIQSIAPSIYG--YEAVKEGIALQLFGCS-PVE LPDE-MRIRGDTHVLLTGDPGTAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SEMLKWVSQ-VAPRGL YTSGKKATGAGLTATAVRD-EIG-GG-WTLEAGALVIADGGLACIDEFDKMSDEDRGAIL ESLEQQTISVAKAGIVATLNTRTSVLAAANPKGGRFDKQ-RNVSEQID---LPPIVLSRF DLIFIMRDEPLAELDRTIAHHMLELH----REPT-------------------------- --------------------------RVVKPPLDVDTLRKLIVYARNSVDPEFEDDEVLK TIENFYVKWRSV-----A----ESGEAP--LPITPRQLEALIRLAKANARMRLSDHVTVE DANRAIKIVSFYLREA-GVDTETG-KIDIDVLMTGRS---RSQREKLQRVLDIIR-ELET ----EYG---G-AAPVEQIKRMAESD-GI-SSS--FVERMIEEEL-RRGHLYEPKQ-GMV SRAMK----- ;Minichromosome maintenance protein MCM n=1 Tax=Candidatus Bathyarchaeota archaeon ex4484_205 TaxID=2012510 RepID=A0A257ALJ2_9ARCH 31Candidatus_Bathyarchaeota_archaeon_ex4484_205__UniRef50_A0A257ALJ2 ------------------------------------MLSRTGSEDPVESFRDFL--LS-- -T-------YRPQVDQLIAEE------RRS-IVIDF-KDLYLFNE------S--LAKQVL -----ESPTKVIPDMEKIAYSVLEG------IDPEYTSGFKF----------FHVRFK-- --DI--P--T---IVSIRDIK--SFHVNKLISFEGVVVRASTVESLLQIGLFE--CNY-- CHH---RMLV---E------Q-EG--EFLTFP-PKCENPG------CKYGGIAKPSN--- -----------FTFIP------EESIFVDVQQLRVQERPEDLPAGQFPRTLDFQV-LDDL VD-----RVRPGDRVSVVGIVKNVIQ--FTGRF----RIRR-RFKIGIECNNIEPLT--- GWEDTPLTQDEIQVIKEMSKDPNIYDRIVDSIAPSLYGKTIRVIKEAVALQLVGGV-AKE FPDG-VRVRGDINILLVGDPGTGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLKYVQR-VAPRGL YTSGRGTTAAGLTAAAVRD-RLT-GG-FVLEAGALVLADKGVAAIDEFEKMRPEDRVAIH EAMEQQTISIAKGGIVATLNARTAILAAANPSGGRYDDT-REFSENID---LSPTILSRF DAIFLLRDKPDPERDSQLAQHILDYH----RGVG-------------------------- --------------------------VASAGMLSPEVLKSYLSYAR-NLSPV-LTEEAAE RIKEFFLEMRRK----------SVGS----ITITPRQLESIIRLAEAKAKIHLRSEIKVE DVETAIRITDFWLNQV-ARSIE-G-YQDIDIIMSGKS---APTRERMSIIRDVIR-ELSI ----GKPN----GANLDLVRENVMERLGI-DET--EFNRLISILR-KEGIIFFPTT-GMV KLVGKK---- ;XRE family transcriptional regulator protein n=36 Tax=Halobacteria TaxID=183963 RepID=V6DVN2_9EURY 32Halobacteria__UniRef50_V6DVN2 -------------------------------------MAQAGTQDLTERFIQFY--RN-- -Y-------YREEIGQLAQRYPNE---QRS-LYVSY-DDLFQF-D--R---D--LAEDFL -----NKPEQMREYAEEALRLYDLP------------ADVSLGR--------AHVRVE-- --DL--P--E---SVDIRGIRVHDDHIGKLVSVQGIVRKATDVRPKVTEAAFE--CQR-- CGT---MTYI---P------QSDG--GFQE-P-HECQ--------GC--ERQ--G-P--- -----------FRVNF------DQSEFVDSQKLRIQESPEGLRGGETPQSLDVDI-VDDI TG-----EVSPGDHVTCVGVLHIEQ---VEQGN----EKSA-IFDLYMDGVSIAIED--E EFEDMDITEADKRDIIELSERDDIYEAMVASIAPAIYG--YEEEKLAMILQLFSGV-TKH LPDG-SRIRGDLHMLLIGDPGTGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQMISYIRH-IAPRSV YTSGKGSSSAGLTAAAVRD-DFGDGQQWTLEAGALVLADKGIAAVDELDKMRSEDRSAMH QALEQQRISVNKAGINATLKARCSLLGAANPKYGRFDQY-EPIGEQID---LEPALISRF DLIFTVTDDPDPEHDSRLAKHIINTN---YAGELN-T----------------------Q REELTTSEFTS--------EQVAEVTEEVAPEIEAELLRKYIAHAKRTCYPT-MTEEAKE LIEEFYVDLRSK-----G----SGEDDP--VPVTARKLEAMVRLAEASARVRLSDTVERE DADRATDIVESCLKDI-GVDPETG-QFDADVVETGTS---KSQRDRIKNIKGLIA-DIEE ----EYQ---E-GAPVDEVLDRAGEI-GM-DPG--KAEQEIEKLR-TKGEVYEPKQ-GHL RTT------- ;ATPase n=3 RepID=A0A2J6XNV2_9ARCH 33_UniRef50_A0A2J6XNV2 ------------------------------------MEIAYTKEKLVDVLEYFL--KV-- ---HESGK-YRGRISQMAVSG------SNS-IVIDY-EDLLRS-L--P---D--AAPMLS -----ENPDFFLEAAKDAALRVLSV------EAPEYAEQARDY---------LKIRIR-- --GY--P--E---RLPLRSIT--AAKLERLVSVNAMVVRTSQVKPLIIEATFR--CP--- AGH---AVPV--RI------V-GR--KLQP-P-DTCP--------VC--EAELGGGERKG RLYRRSD----FKLDQ------RSSKFVDYQVLRLQELPEELPPGQLPHYVDVEV-TGDM VD-----RVRPGDRVVVTGIVRAEPE--SEESRGRPAAALA-IFDTRLEANYIEVVG--K EPEELEITPEDEAAILRLSKDPEAYRKLVSSFAPSISG--HEDFKEAILLMLAGAP-QIM LPDG-SSVRGNINVLLVGDPGTAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SELLKYAAR-AAPRGL YTTGRGSTAAGLTAAIVRE-K-N-GL-MVLEAGAVVLADEGLAAIDEFDKMRPEDRAVLH EVMEQQTVSIAKGGIVATLNARTSILAAANPNLGRYDED-KYLYDNVN---LPIPLLTRF DLIFVVRDQPQRERDVQLAKHMLRAR---SEGQKE------------------------- -----------------------------VPPIGFEMLRKYIAYSRR-LEPK-LTDEAMD VLVEFYADLRSR----------APPEA---IAITPRQLESLARLATARARLLLRDHATKE DAEAAVRLMRISLKGM-GIDIESG-EVDMGELY-GYP---MKERNRMKIATEVFK-KLED ----PKTG----LVQAKQFVQELAAKLEI-DEE--EARKLVEKLW-RAGYIYEHER-GYY KRASI----- ;AAA family ATPase n=5 Tax=Archaea TaxID=2157 RepID=A0A2D6P7H6_9ARCH 34Archaea__UniRef50_A0A2D6P7H6 -----------------------------------------MESETLGRYRTFI--ER-- -------Y-YATQLTK-NVQKG-----SRS-LIIDF-KDLTKF-D--I---N--LSEKLL -----SNPRESLEFIDAAIQEIE-V-------------GEI--N------FKIRARII-- --NL--P--E-SQKFKIRDLR--SEHLGLLITCDGLIRQASDVRPRVVVGTFE--CPK-- CAA---QLRV---D--QT----ES--KMQE-P-KSCN--------QC--RHK--G----- ------------KFTL------IDKKLTDIQQLVIEEPPETLDGGEQPKRXRCIL-DDDL LEPDQERRRYPGNKVKIVGIVKEVAM--SSKTG----AQST-QFDIILECNSVETSD--E DFEELEISKEEETEILRLSKDPKIYDKLIRSIAPVIYG--YEEIKESIALQLFGGV-RKV KDDG-TEWRGDVHILLMGDPGAGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SILLRYIGN-XAPKAR YVAGRGASGAGLTAAVVKD-EFL-GG-WALEAGTLVLANKGMACIDELDKISADDRSAMH EAMEQQTVSISKANIQATLMSQASVLAAANPKFGRFDPF-RPAPTQID---LPPSLINRF DLMFVIRDIPNQDNDERVAKHVLALQ-----GDI-------------------------- --------------------------ESTKSDIEHNLLRKYIAYARQNCFPK-LSDSAQK LIQDYYVKIRGT---ATG----DGGIKS--IPISARQLQAIVRLAEASARVRLSNVVNES DAQRAIKLVXETLKQL-GTDPETG-ELDIDRITTGIT---ASTRNKMSIVRQIIE-SLES ----QFG---K-SVPKSEIFSNAENQ-GI-EKH--KAEELINQLL-RSGDLFEPKN-GFI QRS------- ;MCM domain-containing protein n=2 Tax=Thermoplasmata TaxID=183967 RepID=A0A256ZB80_9EURY 35Thermoplasmata__UniRef50_A0A256ZB80 ------------------------------MEETVEIAKSPSTEDLIEDWMDYF--EL-- KG-------LIGEINDIASIPT-----RNS-LYISY-MDLFSLKE------S--IARALR -----EHPRLVLRAGELAIRKILGP----------EEAGRR-----------INIRFT-- --DL--P--S-EFIVNIRDLR--SVHLDTLVMVEGLVRKATDVKPRLRKGVFI--CQR-- CGH---EIEI---E------M-DY--QYRE-P-LECPEEEGG----C--GRKASSTK--- -----------FELDM------KKSTFVDVQKIEIQESPESLTGGDQPKRLSLYF-YDDI AG-----KVFPGDQVKIWGILRARQ---KRDAY----GKLP-LFDIYLEVNNYDKRE--K SYLELEITEEDEIEIRKYAKRMDIYQLLINSLSPSIYG--MEAEKLSLILQLFGGV-EKN LPDG-TRVRGDIHVLLVGDPGTAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLRYIAD-LAPRGI YTSGKSSSAAGLTAAVVKD-EFGEGN-FTLEAGALVLADGGIACIDEIDKMSDVDRSVMH TAMEQQVVALSKAGIQATLRARCSILAAANPKFGRFGE--REIVDQIN---IPPVLLSRF DIIFAIRDLPNPDLDRRKAVHILNHH---QWGEKK-R----------------------K IEMTTKGRGKV--------EDLEEIEE--KEFIPPELLRKYVSYARQNIFPV-LTEEAKD KIIDYFLTLRSR-----S----HEEGGMKIIPITTRQLEAIIRLAEASARIRLSEEVTVE DADRAIKVFNRYLDSI----TEGG---GIDAIYTGRS---LAKRERLQVILKIIS-ELDS ----ITG---E-GASIEAITDRAKEE-GL-TRD--EVGDVIKQLL-TSGYIYEPRH-NVF KTL------- ;MCM domain-containing protein n=33 Tax=Archaea TaxID=2157 RepID=A0A151E8U1_9EURY 36Archaea__UniRef50_A0A151E8U1 -------------------------------------MVEVDVSEQINLFYKFI--ET-- ------EY-YKDLLSQVNKG-------HKF-LKIDF-NALSKF----NP--E--LAELLL -----EKPEETVKAAELAIDSFDIE-----------GDTKN-----------FKVRFY-- --NL--PASQ---KSQIRNIR--SSDIGKLIEIEGLVRQKSDVRPQVTSARFE--CPS-- CGN---IITV--LQ------L-DT--KFKE-P-SRCS---------C--GRR--G-K--- -----------FRLIS------KE--LVDAQKLVLEEAPEDLEGGEQPKRLNVFL-KSDL VSPMSDKKTNPGSKILVGGVIKEVP---IEIGG----VRTT-RFDLFSDANNVEPIQ--E DFYEIEISEEEEKKILEMSKDKRIFEKLRDSLAPSIYG--YEKVKEALLLQMFGGV-IKK RDRG-DVTRGDIHILLIGDPGSGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQILKRISV-VAPKSR YVSGKGATGAGLTATVVKD-EFLRG--WALEAGALVLTNKGICCIDELDKMTQEDQSAMH EGLEQQTITISKANIQATLKAETTVLAAANPKFGRFDPY-ELIAKQIE---LPTTLLNRF DLIFPMRDLPNKENDDKLASFILHLH---QSAER-------------------------- ----------------------------RETEVNSEMIKKYVSYARRNIHPK-ITDPARK EIQDFFVNMRNI-----G----EKEEAIRAIPISPRQLEALIRLSEASARTELRDKVLKK DAKRAIELVHYCLSQI-GLDPETG-KIDIDRLVTGIS---AVQRNEIAIIREIIN-ELEK ----VLG---K-AVPMEDVEREAEIK-GI-EKD--KVDEVIEKLK-RTGDIFSPRH-GVI SKI------- ;Minichromosome maintenance protein MCM n=1 Tax=anaerobic archaeon MK-D1 TaxID=2594042 RepID=A0A5B9DAJ8_9ARCH 37anaerobic_archaeon_MK-D1__UniRef50_A0A5B9DAJ8 ----------------------------------MVIESDSLPANPISDFEEFF--KE-F EESPNIFK-YRQKISEAYSKS------ENF-VTVLF-EDILNF-K--P---M--LANYLK -----NHPEQALHDAVDAFKNIIRI-----DAGGLFNPNEE-----------YMVRIA-- --TA-----NNSNDVNLRKIR--SVHIDKLIYVKGIIIRASDVRPQITQAVFE--CPL-- CGN---IMQE-EQA--------TK--KLTP-P-NLCTNP------NCKNNRN-------- -----------FRVIT------DESEFIDYQLITIQESPEELRSGDIPKTITAIL-YHDL VD-----TVRPGERIKIMGILKSIP---KEDRR----GRLSTIFMIQLIANSIEGLT--S EDEELELTQDDIDQIFALSQEPLIQKKIARSIARTILG--QEQLKMAAAMSLFGGI-QKK KKDG-SKLRGDIHVLFLGDPGTGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQILQSCSM-ISKRSV YTSGKGSSAAGLTAAVLRE-NDNSG--MQLEAGALVLASGGIACIDEFDKMRKTDRVAIH EAMEQQSISIAKGGIVATLQAKTAIIAAANPKHGRWNEY-ETAVENIN---LSPPILSRF DLIFVIRDKPDKHEDDIIAEYILTSH----MQGYDDT----------------------- --------------FSLEEDESGKPPKATLDFIPMELLKKYIRYCKNNSFPK-LTKKTAE KIRNFYVEMRNS-----N----PEGSTA--VSIVARTLDGIVRMCEAYAKMALRDVVTEE DVDAVIELVKRYMKDI-GYDEETK-TYDIDIMMTGRT---HSKQDRFNKILSKIK-ELTL ----ADPT--T-PLVFDDIYEPIATLQGI-TKE--FVQQALNEWA-NEGTLYCPKP-GEY RLTKKPK--- ;AAA family ATPase n=5 Tax=Archaea TaxID=2157 RepID=A0A497HLI2_9EURY 38Archaea__UniRef50_A0A497HLI2 --------------------------------------MVVEVLTLEEKFEKFF--RS-- -Y-------YYRDILRIVRGYP----QERS-LVVDF-DILDGY-D--F---S--LAEELI -----RNPDETIKSAEKAIRNLELP------------IDLPSIN--------INVRFQ-- --NL--P--S-AYKYLIRDLR--SEDVGKLIGVEGIVRKSTDVRPKLVVGAFE--CRV-- CGN---IMRI---P--Q---D-GE--KLRQ-P-YMCD----S----C--ERK--G-P--- -----------FSLLL------EESTFVDSQKILIQESLEDLRGGEHPQQLTVYL-EDDL TG-----KIFPGDRIEIVGILRAKR-------N--K--KTR-VFDIFLEANSYKPVE--L DFEEITITKEDEKKIIEFSKDPKIYDKIRDSIAPHIYG--YRDIKEAIMYQLFSAP-PLE LPDG-GRIRGDSHIIIIGEPATGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SEILQYVAKELAPRGI YTSGKGTSTAGLTAAAIKD-EFGEGG-WSLEAGALVLADKGIACIDEFDKMESSDRAAMH EAMEQQTVSIAKAGILATFRARCSILAAANPKFGRFDEY-KAISEQIN---LPPTILSRF DLIFFVKDELSETRE--VARHILDTV---ISPES-------------------------- ----------------------------ITPPVPPDFLRKYIAYARQRIFPK-LGEEARK KIESFYVEMREA-----AQ---RAEDVP--IPLTARQLWAIIRLARASARVRLSEVVSEE DVERAIRLVKLSLKQA-GLDLETG-KVDIDKIMLGVT---KSQREKIKILIDIIK-ELEE ----LHG-----TAKKTEIIQMASEQ-GI-SRD--NVEELLQKLK-RDGSIYEPRH-EHY KVV------- ;AAA family ATPase n=1 Tax=Euryarchaeota archaeon TaxID=2026739 RepID=A0A2D6JCN1_9EURY 39Euryarchaeota_archaeon__UniRef50_A0A2D6JCN1 ------------------------------------------MQDSIDKFEQFF--KT-- ------KK-YYGRLLEIAKEYP----DKRS-VLVDF-ADIDKS----FP--N--LADDLL -----LHPEEALRQAQDAISEIDLP----------IDVENL--S--------INVRLH-- --NL--P--K-AHTIVIRDVR--SDHLDRLISVEGIVKNAAEVRPKALKVTFE--CPE-- CKT---NMVL---P--Q---F-TK--NMVS-P-SQCDNF--E----C--ARR--G-R--- -----------FKIIN--------ETLIDSQILKVQEAPESIFGGEQPSELYVHL-SDDL VSPPERKKVMPGNRVQLVGSLKKVP---IPSRS----GAQTVNYDFYLEVNHVDPTE--Q EFQEIDLSDEDIEKIKKFSKDPKIYEKLIASIAPSIRG--NEAIKEAILLQLMGGV-RKQ HPDG-TLVRGNVHIFIVGDPAVGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQILRYVSG-LAPKGR FVSGKKASGVGLTAAVVRD-DFA-GG-WTLEAGALILANNGIVSVDEFDKMSDDDRSAML EAMEQGTISIAKAGIVTTLRANTSVLAAANPKYGRFDVY-KPLYEQID---LSPVILSRF DLKFTSRDLPGSDKDTLLSEHVLTAL----ISPK-------------------------- ---------------------------TIEPEISSEFIQKYVAYAR-NLDPE-MTEKAKE LIQHFYVSWRGK--------YRDDDDNGGVVPLTPRQLEAMVRLSEASARIRLAKKVSLN DAKRATKLIEQSLRDL-GTDPETG-KIDIDRMEAGTS---SVQRSRINTILTIID-ELSK ----EQG---P-NIKIDDVLIEAANR-GI-DNL--KAVELISKLK-SKGDLFEPRQ-GIL KKP------- ;AAA family ATPase n=5 Tax=Thermoplasmata archaeon TaxID=1906666 RepID=A0A497HGB2_9EURY 40Thermoplasmata_archaeon__UniRef50_A0A497HGB2 ---------------MDKEIRQIDEAEDVGYEEMLDLYRKMSITDLSARWERIL--DR-- ---------FDKEIQDAIITG------QTS-ILLDF-QKLDMI-D--P---V--MMELFI -----EKPYTVLYVLDKVIRDITEG------------EEHQI----------RSARIY-- --NL--PEWA---TVQIRDLR--ASHLGKIVCIKGLVRKATEVRPKIENAYFQ--CNK-- CGA---VFSY---P------QKGQ--TLEE-P-YECPTDQGG----C--GRH--TS---- -----------FTLLT------EDSVFVDSQKIEVQENPEGLFGGEQPQKISVYL-EGDL VA-----KVFPGDEVTIIGIVNGKQ---RWTKG----GKQSTEFGMVIDAHNIIPNI--R AFEEVKILDEDIEKIKELSKDPQIHEKIRNSIAPTIYG--MEKEKDALALQLFGGV-PKV MPDG-TKIRGDIHVLFVGEPGTGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLKRVKD-IAPRSV FTSGKGSSAVGLTASAVRD-DFGEGR-WTLEAGALVLADQGLAIVDELDKMRAQDRDALH EAMEQQEINIAKAGINATLKSRCSLLAAANPKFGRYDPY-GVIADQIN---LPPPLISRF DLIFPIIDKINQERDRKLSSHILKSH---RVGQIL-H----------------------Y NEVRNDNISID-----------NEDMDLLTPEIDRVLLRKYIAYAKREVCPI-MTEEAMK KLEDFYVDMRKQ-----G-----IDSSS--IPITARQIEGMIRMAEASAKIRLSNEVTEE DAQRAIDLLMYCLSKI-GFDADTN-TFDIDMVATGVK---RSQADKMRIIKRIIE-EGME ----ESED--E-LVSLEYIAEKAKEKLDM-EFE--EVEHLIEKMT-TDGILCEPKY-KHF QPT------- ;AAA family ATPase n=1 Tax=archaeon CG10_big_fil_rev_8_21_14_0_10_43_11 TaxID=1975556 RepID=A0A2G9P9L6_9ARCH 41archaeon_CG10_big_fil_rev_8_21_14_0_10_43_11__UniRef50_A0A2G9P9L6 ----------------------------------MEQEQELKETKIIQLFEEFL--RD-- -T-------YYRELVDATESD------SKS-LFIDY-AVLSIT-N--A---E--LADAIE -----KHPKKTIDSFKKALQNIDLP-------------RTD-----------INLRFV-- --NV--PAGM---IVPIRNIR--SEHIGKFFAIEGTIRNASEVRPVSKAAVFE--CST-- CGA---DNIV--KQ------R-ET--KFTE-P-THCVN-------NC--VRA--R----- -----------FKL--------KKQLLIDTVNVTIEESPETLDGGEQPKRLFAFL-EDDL VSPTREKEILPGNKVRLIGVLKEYPV--VLRTG----GQST-RYEFILETNNVEPIQ--K EFESLDISKEDEEKIKEISKEPDLYLKLRKSIAPNILG--YDEIKDALVLQIFGGV-RKM RKDG-TSSRGDVHILLVGDPGTGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQMLTYMHR-LAPKSV YVTGKGTSAAGLTATVIKD-EIS-KD-WILEAGALVLANKGVAVVDEFDKMDHEDRVAMH EAMAQQTVTINKANIHATLNAQASVLAAANPKLGRFDPY-TVITEQIN---LQPTLINRF DLIFTVQDIPDQQRDEKIAKHVLQIH----KNPK-------------------------- ---------------------------EFDAPYEASLFRKYVAFAKKTCKPA-LTDEAIE EISNFYVKLRTR----KG----MDEKELSAIPISARQLEALVRLAEANARIRLHNKVEKS DARRSIELLQYSMNQV-GIDPETG-ELDIDRIVTGIS---QSQRNKILVLKDIFK-ELES ----KHG---E-QIPIEDVLKAAAAR-GI-DEG--KAEEIISKMK-KNGEVYEPRH-GRL SRMK------ ;MCM domain-containing protein n=16 Tax=cellular organisms TaxID=131567 RepID=A0A497PEL8_9ARCH 42cellular_organisms__UniRef50_A0A497PEL8 ---------------------------------------MLKDESLVASWQSFF-EEN-- ---------CKSEIETIALEYPE----NRS-LIVDY-WDIDKV-Y--P---T--LTEMLI -----NQPYKTFFNAKEALKNIDVA------------AEHKLQ---------LQFRVD-- --NL--PDTQ---KILIRKIR--ANHLGKYTAIEGLVKKVTEVRPKLQVAVFQ--CQK-- CGA---IIKI-DQE--------ED--ILKE-P-SECYEDQGG----C--GRI--SS---- -----------FKLLT------DLSTFIDSQKIEIQENPEGLRGGAQPERISAYL-EDDL VG-----MLAPGDRVIVNGILHSQQ---RRRGP----LRLT-SFNKVVDAYSTERQE--L AFEEVEVTPEDEEEILKISKDPDIYNKMRQSIAPTIYG--MNVEKEALALVLFSGL-SKK MPDG-TYIRGDIHVLLVGDPGTAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQILTYMSK-LAPRSI YASGKASSAAGLTAAAVRD-EFGEGR-WTLEAGALVLADMGIACIDEIDKMEETDRSSMH QAMEQQEISVAKAGINATLKARCAILAAANPKLGRFDEF-IPMHEQIN---MPPALLSRF DLIFSILDKPNRETDTALATHILRTH---KAGEVS-E----------------------N ILRSKKSKHTK--------EEQDGLMKNIMPIFTPEFVRKYVAYAKRNIFPV-MTDDASE VLKNYYVDFRSA-----S----ED---S--VPFTPRQLEAFVRLAEASARVRLSEEVTVE DAKRAISIIDQYLRRV-GMDRETG-KFDIDIIATGIS---HTQQSRMRSIIDIIQ-KLCN ---ASEDD--N--ATRSDIVSEAEIE-GI-ESS--KVEDALDRLK-RHGQIYEPIH-GKY RVTE------ ;AAA family ATPase n=1 Tax=Candidatus Aenigmarchaeota archaeon ex4484_52 TaxID=2012504 RepID=A0A256Y1J0_9ARCH 43Candidatus_Aenigmarchaeota_archaeon_ex4484_52__UniRef50_A0A256Y1J0 --------------------------MENKKDIKEINNSKENDNDLVNLFSSFI-EKK-- -Y-------FQTAQKRFSENKP---------LVIDY-NEISQF-N--A---K--LADELI -----ENPDVWFEYAQEAIDLIDFG------------IEGK-----------KIIRIF-- --NI-----HNHKILKIKDLR--SEHIDKFISFEGIIKQASEVRPEVVFVTYE--CPA-- CNA---KITV----------IQDG--VLLKKP-YVCE---------C--GNK-------- -----------RAFSS------IMRKLRDVQRLEIEEIPEKLEGGAQPRKIGVFL-RDDL VDPLFQKNVVPGTKINLTGILRDVAL--KVDDG----RETR-RRDIFLESNYLTVIE--Q EFEDVELTKEDEEKIKQLASDEKIYSKLVKSIAPSIYG--HDKIKQAIVYQLFGGS-RKE RSDG-VTTRGDIHIFLVGDPGSGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQILKYISK-LAPKAR YIVGKSTSGAGITATVVKD-EFMRG--WALEAGALVLANKGIALIDELDKMSKDDRSSMH EALEQQTITISKANVQATLHAQTTVLAAANPKFGRFDPH-SPIAEQID---IPDTLLSRF DLIFPIRDVPEKKRDTKLVKHILKMH----ENEN-------------------------- ---------------------------DEKAPIDRNLLRKYISYSKINIQPK-LNKEARE EIENFYVNLRSK-Y----S---SEEKNI--VPLGARQLEALIRLSEASAKIRLSKRADSE DAKRAIKIMRYCLTQI-GVDPETG-EIDIDRLEGRTT---GVQRNKLYVMLKIIE-DLQK ----SSP---ENIALIDDILEQAENQ-NI-NRV--DAEVLISKLK-TSGDIYEPNI-GKL KRL------- ;Replicative DNA helicase Mcm n=1 Tax=mine drainage metagenome TaxID=410659 RepID=T1BPT0_9ZZZZ 45mine_drainage_metagenome__UniRef50_T1BPT0 --------------------------------MVAAKRILPAPTELHARWQAVF--EE-- ------AG-LRADILGLADRFP----EERS-LEIPF-QTLDRI----DT--T--LGDLLL -----DRPEDVLPAGVRGLRELLPL----------DRPELS--G--------LRLRIT-- --GL--P--P-TAHRLIRDVR--ETDLGRFLALDGIVRKVTEVRPQVREAVFE--CVA-- CRT---EIRE---T--Q---D-ADAMLFRE-P-LECPEAQGG----C--GKPQGR-T--- -------R---FRFLA------DKSTYVDSQRIEVQENPESLRRGAHPQGIPVLL-TEDL AG-----HVIPGNRIVANGVLKGVQR--TSGGGRGGLVRNT-VSDLMLIGNSVESKQ--L EYDEIEITEEEERLFLQFQDDPTVIDKIVLSLAPTIKG--MEEEKEAIALQLFGGV-AKR HPDG-IRTRGDMHVLLVGDPGTAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLRYIAD-VAPRGI YTSGKGATAAGLTAAAVKD-DFAGGR-WVLEAGMLVLADGGMAVVDELDKMTPEDRSAMH EALEQQTVSISKAGITATLNARCPVLAAANPKWGRFDDH-RTIAEQID---LPATLLSRF DVIYSIKDRPNQERDRTLAKGILGSH----RDSELPE----------------------- -----------------IPDATGRTPGTLAAPFSADLLKKYVAYARRKIRPA-LSDAALT VLEDFYVTVRRQ-----G----EEPDAP--VPITARQLEALVRMSEASARARLSHVVTVD DAQRATRIMDSFLHRV---SSSEG-KLDIDLVTTGTS---RSQRERQDMLLKIMR-DLQS ----NDPG--R-TFTLEQLKAAAEPQ-GI-PQD--RVDQLVSYLK-NSGELFEPRP-GAL QLVRF----- ;MCM domain-containing protein n=5 Tax=Archaea TaxID=2157 RepID=A0A1J5JLF1_9ARCH 46Archaea__UniRef50_A0A1J5JLF1 -------------------------------------------MDITEQINIFI--TENY KE-------YVEECF--IKDQP---------FIIDF-EMLEQK-D--P---E--LTDKLL -----DDPETVLYFFNKILKELAPT----------SAKDNR-----------IYARFK-- --NV--PGSR---LINIRDLR--SKHLHKFIKVRGLIKSSTSVRPQTTEMIFE--CPN-- CGA---KISV--IQ------T-GM--KLTV-P-TTCE---------C--GRR--G----- ------------QFKE------LEKRFIDVEHIILEESPEEIE-GTQAQKISILL-KDDL IASSLQKTIQPGSKIELVGALQEVP--IILTTG----GRSV-NFDFQIDANNVTPIE--Y EFEDIKITQEDENQIFDAAKDPELFKKLRESIAPSIYG--YGKIKEALVLQLFSGV-RTV LPDG-TVRRGDSHILLIGDPGVGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SMLLMQIAT-LAPKAR YVSGKATTGAGLTATVIRD-ELI-GG-YALEAGALVLTNKGIVLIDEFDKMSEDDRSAMH EAMEQQQISISKANIQATLKAQTTVLAAANPKFGRFDSR-RSVVEQIN---IPDTLISRF DLIFIIQDIPNKTSDEALAAHILTVH---KSSEN-------------------------- ---------------------------MFKTPFNKEFIRKYIAYARAHIKPE-LTKEAME EIKEFFTSLRAR-------YEQQEGEKT--IPISARQLEAIIRLSQAAAKMRLSNKVEAR DARIAIELEKYSLRQV-GYDYETN-QYDIDKIVVGST---AHQRSQNMVFTDEFF-ALLK ----LNK-----VIKRKDIEKLAEKI-GL-HKQ--KADQIVDDLK-KEGRIFEPKP-GEL QEI------- ;MCM protein n=14 Tax=Euryarchaeota TaxID=28890 RepID=A0A0A7LIF5_9EURY 47Euryarchaeota__UniRef50_A0A0A7LIF5 ------------------------------------MTVNFQDSEIVAGWEDIL--SK-- ------DK-YRIMFADIAASYP----DKKS-IYVDY-EDIDAY----NP--D--LAMFFL -----DNPSKCLHKGAEVVRSSLPP----------TWDMKD--T--------VNLRIT-- --CL--P--R-DAKVEVRHLR--AKHLGKLVAVEGLARKVTTVKPRMTQALFR--CSR-- CGA---EIWE---K--Q---R-GV--LMKE-P-LMCSNPDGS----C--NKQ--A-T--- -------H---FELDS------KASVYIDTQKIEIQESPEGLRGGAQPERISGFL-EDDI AG-----IVTAGNRITINGIVRSAE---KPDRD-----KTT-IFETFMDVISIEFEE--H EYDEIQITEEDELQILEMSQDPKLFDNIVASISPTIFG--MTEVKGAIALQLFGGC-NKE MDDG-TVIRGDMHVLLVGDPGVAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQILRYMST-LAPRGI YASGKSASAAGLTAAAVKD-EFGDGR-WTLEAGALVLADKGLACIDELDKMTPQDRSSLH EAMESQRISVAKAGITATLQCRCSMLAAANPKFGRFETTGTSITSQID---LPPALMSRF DLIFVLTDKPNAKTDMKLTSHILNVH---RRGEAR-H----------------------V KDDAPMVVGIDL-------KKIKENTQAIKPVYDQDMLRKYVAYSKR-IVPV-MTDEAMS IIEKTYLEIRAQ-----G----AGENDS--VPITARQLEAFVRLSEASARMRLSYMVEGA DAQRAVDLVQYYLDKI--LAPNGG-QWDIDNLSADYT---KKDRNELNIILDVIR-EYGS ------ID--G--LSEEEIISHSLNE-GL-SED--KAKRRLRMMK-EDGTLFSPRNDGRY KGA------- ;DNA replication licensing factor MCM related protein n=18 Tax=Archaea TaxID=2157 RepID=Q9HK10_THEAC 48Archaea__UniRef50_Q9HK10 -----------------------------------MISSEVSEDRIKDLWRDFF--RL-- YG-------YSDEINRIHQEYP-E---VRT-LYVSF-RDLEDY-N--W---Q--FAGSIL -----VSPEIYIRAGEEVILQDYLL----------DRVTQRFNI--------FNLRIK-- --DL--E--EKNVAYRIRDIR--SANIGTLISVSGIVRKNTEVFPKLKNAAFE--CSS-- CHG---LTYV--EQ------T-EN--RLSE-P-QVCD-------H-CGLSRGKDK-IF-- -----------FKLRP------NLSEFIDVQKVEIQEDPETLEGGSQPQRITIIT-EDDL AG-----LLYPGNRVIVDGILRTEQ---RRQGN----IPLT-EFFTYLYAINVRKDV--K ELESVKITEEDKKRIIEISKKPDIIDVISRSIAPTIHG--LDMVKKALALQMFGGV-RKV MKDG-TTMRGDIHILMVGDPGTAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLKYMAE-VSPRGI FTFGRGSSAAGLTAAAVRD-EFGEGR-WTLEAGALVLADNGFVAIDELDKMDEHDTAAMH EAMEQQTVTISKAGIMATLKARASVLAAANPKFGRYDLN-RNLAEQIN---FPLPLLSRF DVIFKMVDHPNKDSDSRLAEHVLKAH---RIGEI-------------------------- -----------YRSIEHSDADIEIDEQGFEPEIDKDTLRKYVAYARNNVFPR-LSDEAIA ILQDQYVKTRST----------SHD--A--IPITVRQLESTIRLAEAAARARLSTIVTVE DALLAKKIVDYYLMDV---SMDNG-KMDIDIIYTGAS---SKQRNDMETVLDIIK-QLKS ----EKG-----MAEVADVINVAMSR-GM-TQK--KAEEALLKLK-NAGQIFEKSY-GKI DVIS------ ;Minichromosome maintenance protein MCM n=2 Tax=Euryarchaeota archaeon TaxID=2026739 RepID=A0A534JPG1_9EURY 50Euryarchaeota_archaeon__UniRef50_A0A534JPG1 --------------MIPDEPSLSGEPTPGRDKGRSRTLAEYSLEELIARWEEFF--SELG ---------LESEIIGLADRYPE----GRS-LKIRF-EDLNRF-D--T---D--MSIHLL -----RQPLNVLTAGEEAIRRVVPP----------TEEPVE-----------IHLRVQ-- --GV--P--R-DSRVQIRDLR--AKHLGRFIAVEGLVRKATEVRPMVVDALFQ--CLR-- CGT---VIKE---P--Q---E-GQ--AFRE-P-MECYEDQGG----C--KRTANATK--- -----------FKLLG------EASRFTDTQKIEVQEAPEGLRGGEEPQRLSAFT-EDDL TG-----KINPGMRVILNGILRSSQ---KGRPG----QKST-LFDILLDVNSTEFEQ--V EFEEIEVTPEDIKKIEAEAADPDIYRKIVASIAPSLYG--LTTEKEALALQLFSGV-AKE MPDG-RRIRGDIHILLVGDPGTGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SELLSYMSR-LSPRGI YATGKAASAAGLTAAAVRD-EFGEGR-WTLEAGALVLADKGLAAIDELEKMNPQDRSAIH EAMEQQRISVAKAGITAVLQARCAVLAAANPKFGRFDET-KFVAEQLD---LAPTLLSRF DVIFSLIDHPESERDRNMAEHILRGH---LVGEW-------------------------- RRRRAEGKEVP--------DENVEYIEAYSPHFEPIFFRKYVAYAKR-FSPV-MTPESME TIKAKYLEIRKA-----G----EPAGAS--VPITPRQLEAIIRLAEASARARLSQRVDPE DAERAVRITEYWMRRVAG---EEG-RFDIDIVQTGIS---QSQRDQIITLRDVIN-QLSE ----QGPS--G-SADYEDIVRVAGER-GI-PQV--KVDQWLKRWA-QEGDVYTPGK-NKY KLVERL---- ;Minichromosome maintenance protein MCM n=1 Tax=Euryarchaeota archaeon ADurb.Bin294 TaxID=1852878 RepID=A0A1V5SF76_9EURY 51Euryarchaeota_archaeon_ADurb.Bin294__UniRef50_A0A1V5SF76 -------------------------MNLSDACGPVSSGSSAIIVDRDAIWYSIL--NE-H PT-------IKKEVLKLSREYPK----KRS-LNLDY-RVIEAYGF--P---GISLADEIL -----DNPLKTMKDVQDCILVHSLV-------SNQKTLNIP-----------IHVRFF-- --NL--P--R---RTSIPDIR-ENLHVGKLVSIEGIVRKSSEVRSRLTVAIFR--CRA-- GHR---TTRI----------QGPG--PIRF-P-QECSAD------GC--NQT--K----- -----------LEFQE------EFSQYVDTQRVKIQESPEGAGAGSSLETIDCQI-SDDI CG-----LIKAGDRVCINGIVKRFQ---RGQST---------TFDRYLEVVSIEIQE--K EFGEITISEDDEKSIRELSKDKDVFIRFFHSISPSIYG--MDDIKKAIVLQLFGGV-PKN LPDG-SRLRGDIHVLLIGDPGSGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQVIRYVTK-IAPRSI FTSGKSSSSAGLTATAVKD-EFD-GR-WTLEAGAMVLADMGVLALDEIDKMNSHDRSSLH EAMEQQSLSVAKAGICATLLTRTSVLAAANPKLGRFDNY-LPIAEQIN---MPPSLLSRF DLIYLVTDKPETTHDTKLANHILSAH---STGTEL-L----------------------- -----KAEHEK--------REPVILENLVLPPIHPVLMRKYIAYAKR-IIPV-LTPEAKL KLQNYFVSVRSE----------ASEGKP--VPITARQIEALIRLAEASARVRLSETVDER DAELVIHIVDQCLRKV-AYDPKTG-ELDSDRWGGDKP---KSTRDLIKEFDKTYD-RNQD EDG--WA-------EEAVIFEILLKS-GH-ARS--EVERIISEKK-RIAE-FTEKK-GKI RRI------- ;MCM domain-containing protein n=23 Tax=cellular organisms TaxID=131567 RepID=A0A1J4RJT8_9ARCH 53cellular_organisms__UniRef50_A0A1J4RJT8 ----------------------------------------MKNNDIIDQFTEFL--RE-- -------K-YYKDLAL-AVSQG-----SRT-LKVDF-SELDKF-N--P---D--LADAIL -----EKPDENLEIINESIKQIDFP---------------K--K------GEIKIRFF-- --NL--P--E-NTGLRIRNIR--AEHIGKFLTVDGIVKRASEVRPEISEIVFE--CQE-- CGQ---RMNV------IQDKK-EK--TISY-P-VKCD---------C--GNR-------- -----------RNFKV------IKEKLFDARWVAIEE-PYEITTGERPSEIMIFL-KEDL VSPKLRNKSEPGNRIKVFGILKEVPK--KTAKG----TKTR-QMEILIDANNFETSE--E EWDEIDISPEDEKKIKGFAKDPEIYQKLIGSLAPSMYG--LENVKLSIILQLFSGT-PHF LKDG-TRIRGDIHVLLIGDPAVGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SMLLKLASD-IIPRGK YVSGKGVTGPGLTASVIKDEQFM-GG-WVLEAGALVLANNSLVSIDEFEKMNSDDQVAMH EALSLQTVSIAKAAIVATLPAKTSVLAGANPKFSRFDPY-IPIREQIN---ITETLLSRF DLKFALRDIPDAKTDEKMVDHILDAR----HFKQ-------------------------- --------------------------DESKPIIETQFLKKYIAYAKMHCRPE-LTQEAGK KLKDFYVGLRSK-----S----TGEESP--VPITLRQYEGLIRLSEASAKVRLKEKVEEE DAQRAIDVLKYSLRQF-GFDPETG-LIDIDRAEGAAAT--SAQRSKIRILLDVID-ELSQ ----SIG---K-NIPIEEIVKLAKEK----NVE--RPEEIIKKMK-EEGLIFEPKP-HVV QKV------- ;AAA family ATPase n=1 Tax=Thermoplasmatales archaeon SW_10_69_26 TaxID=1919232 RepID=A0A2P6VU42_9EURY 54Thermoplasmatales_archaeon_SW_10_69_26__UniRef50_A0A2P6VU42 ------------------------------MATPVQVSTTLTKEALRRSWEQYL--RT-- -Y-------QRSQLDQVALAYP----EESS-LLVPY-WQLAKH-D--D---E--LADATL -----ENPVESLEAAKEAVRRLETP------------VDEPLD---------ITVRVY-- --EL--P--E-HWLVPIRQLR--AEHLGRFVAIRGLVKKASEVRPKLEVGAFE--CLR-- CGH---TEHV---E--Q--DD-HL--TFKE-P-QGCQ----Q----C--EKQ--S-Q--- -----------FRFDE------GDSTYVDTQRLELQEAPEGLRGGEQPERLEAYV-EGDL AG-----DVAPGDRIILNGVLRSDQ---RRING----QPST-LFDLYSEVNSVEVQE--Q EFDEVDIGEDEVEEIMEFARDPDLYQKIVESVAPTIRG--MEMEKQALAMQLFGGV-AKR MPDG-SRIRGDIHVLLVGDPGVGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLGFAEK-IAPRSV YTSGKSSSAAGLTAAAVRD-DLADGR-WTLEAGALVLADKGLCAVDEIDKMDRKDQSSMH EAMEQQTVSIAKAGIQAELRSRCAILGAANPKFGRFDPN-QPLAEQIT---MEPALMSRF DVIFTLTDDPEEEKDRELADHIMGVH---RAGAIR-E----------------------Y RDRHEEGLFTE--------DDQEEANQVVEPPVDEDFLRKYVAYARRECFPV-LTEEARE HLQDYYVQIRGE-----G----GEDSGR--IPLTPRQLEALVRLTEASARIRLSNEAELE DAQRAIDIVEYWLRKI-GGGS--G-LMDIDLVASGVG---HSQRERIRILLDIVR-ELSE ----ENP---D-GAPYDVIVAQAAER-GI-TEH--QVEDTIKMLKNQRGTLYSPDNGDHY RLVRD----- ;MCM family protein n=1 Tax=Methanohalobium evestigatum _strain ATCC BAA-1072 / DSM 3721 / NBRC 107634 / OCM 161 / Z-7303_ TaxID=644295 RepID=D7E6T1_METEZ 55Methanohalobium_evestigatum__strain_ATCC_BAA-1072_/_DSM_3721_/_NBRC_107634_/_OCM_161_/_Z-7303___UniRef50_D7E6T1 ------------------------------MSISETELLTSERPNPSELSQEQL-IEVLI RY-------YWDELTEHLKDYPA----TKS-IPIDY-YSLDHPRY--P------FADLLE -----ENPDIFLSLFHDAVYNMTLP------------VDVGQD---------VVPRIY-- --NF--P--E---QTNISSFR--SDHLMKFVSIPGVVKKVSKVKPMIVNAAFY--CMR-- CEH---ITYI---P------QTGS--KFTE-P-HECENE------VC--GRK--G-P--- -----------FKTLV------DKSSYRDVQIIEIQENPEDIEKSQ-PETLICYA-YDDM VQ-----TCKPGDKILVNGVLQSRQ---EESSK----GKKP-FFKFLLDVNNIIKQD--K DFDEIELTPEDEEQVLELSRDPNIKDRIAGSMATSIYG--YQNLKKAIAVQLFSGV-SKT HEDG-AYTRGDIHVLAVSDPGMSK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SKLLNYAAT-LSPKSI ITSGKGNSAAGLTASVIKN-DPDMDDQFALEAGALPLADKGLCCIDELDKMSEEDRSALH DAMAQQKLPINKANIHLTLSTRTSVLGAANPKYGRFDEY-ESLSRQVQ---MAPSLISRF DLIFLMLDKPDDVKDRELSDHIIATH----IKSSARQ----------------------- ----------NLTESEYLQIKQQLEEKSDDSVLSFDLLQKYISYARHNVVPV-LPVELKD RITEFWMNLRHN----------KGDDS---IPVTPRKLESIIRVSEAFARMRLDNRVNEQ DVQDAIDLIQESLKQS-AVDPQTG-KLDTDILETGTS---NSQRSKIKDLYWVIY-DLED --ANAQMGRQK-GVSIHDIYEE-AQKEGI-SND--QVDEAIGRMR-KQGDLMEVDT-GTY IIC------- ;AAA family ATPase n=7 Tax=Archaea TaxID=2157 RepID=A0A497RWJ3_9ARCH 57Archaea__UniRef50_A0A497RWJ3 ---------MRNRYWLSSGVICICQFNFSPDSIFYQDSILLTPLRMKEKIERFL--KK-- ---------KKKEINRIAELYPE----EKS-LLIDY-EELERY-D--R---G--LAEELI -----RNPDEVINAFEDVLSGMNIP------------TIVENPR--------LHVRFH-- --NL--PKEK-GYSLMIREIT--SDYIGKLMAVEGVVNRVSDILPKVSVARFY--CNK-- CGE---AHDE-PQP--------TR--FLRE-P-LFCR--------NC--KRR--D----- -----------FRFVP------DESEWTDVQRLQIQEPLELLEGGEEARQIEIWA-EDDL TG-----RATAGDKITETGIMRLLP-----PRK-----KGS-VYYKFHEANFIEGIE--K EFEELEITKKEEREIKKLSKDPKLYEKIINSIAPSIYG--YREIKEAIALQLFGGRVGKK LPDG-TTVRPDLHILLIGEPGVAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SRILQYVTQ-IAPKSI YVTGKGTTGAGLTVAAERD-EFAEGA-WTLKAGALVLAGGGIACIDEFDKMSPDDRSAMH EALEQQTISVAKAGIVARFKANTAVLAASNPKFSRFDPY-KPLAEQFD---IPPTLLSRF DLIFPIRDVLDKELDKEIADHMLKMH---KTGEE-------------------------- -------------------------MKELEPEIPTDLLRKYIAYSRRNVHPV-LSDDAAE KIKEYYVNLRSS----------GGET----VKATPRQLEALVRLAEASAKVRLSDTVTVS DAERAIKLTDFVLREI-AYDESTG-QIDIDRIVTDHP---KSTRDRIRVIETIIQ-ELIN ----ESGD--G-MASSEDIIEEAKSR-GI-DRF--RAEQILIELK-TKGVIYEPRH-GRY MLTEG----- ;Minichromosome maintenance protein MCM n=9 Tax=Euryarchaeota TaxID=28890 RepID=A0A534IJL5_9EURY 59Euryarchaeota__UniRef50_A0A534IJL5 ------------------MVSGVQAPVPSKAGGRSGAVSEYSHAELVQRWEEFF--DS-F D--------YAGRIMSVADGYPE----ERS-LEVFF-DAVNRF-D--T---D--FGIHFL -----AHPQSSLVAGEEAITRIAPP--------GDVPIK-------------VHLRVK-- --GL--PRDT---RIMVRDLR--AEHLGRFLTVEGLVRKATEVRPKVVDATFQ--CLR-- CNA---IIKE---P--Q---E-GQ--AFRE-P-LECYEAQGG----C--GRSAASTK--- -----------FKLIG------ETSQYLDTQKIEIQEPPEILRGGQEPQRLEGYM-EDDI TG-----LVMPGERIVLNGVLRSAQ---RGRPG----AKST-IFDIFLEVNSAEKER--V EFEDIHITPEDVREIQEEAAKPEIVDRVVQSIAPTIFG--LEREKEALVLQLFGGV-PKT MPDG-TRIRGDIHLLLIGDPGVAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLYYMST-IAPRGI AVSGKGTSAAGLLAAAVKD-EFGEGR-WTLEAGALVLADRGLCVIDEIEKMNPSDRGSIH QAMEEQMVHIAKAGITATLPSRCAVLAAANPQFGRFVQG-KYIADQIN---LEPALLSRF DGIFPILDIPQADRDRQMAEHILHSH---RLGEI-------------------------- LKNREELGESP--------AED-ELAEPYRPHFKPEFLRKYVAFAKR-IYPV-MTPDAMN RIRDHYLEIRKQ-----G----EAPGSS--VPITPRQLEAFVRLSEASARARLSVLVDAQ DADRAVSIIEYWLRRVASEGTETS-PLDIDIVTTGMA---HSQREQVVLLRDIIA-ELGG ---TETGE--G--ANHEDILDLAERR-GL-ARD--RAEAWLRKWR-QEGELYSPVE-GRY RLITRL---- ;MCM family protein _Fragment_ n=1 Tax=uncultured haloarchaeon TaxID=160804 RepID=A5YS59_9EURY 60uncultured_haloarchaeon__UniRef50_A5YS59 MSSKSCIPAFILFGKELYTHPYKTILHYSKMTFVDITNSIAADELIVSKFQESV--IQ-- PH-------YAQDIVSFEDAID------DT-FYMQW-EDIENS-Y--P---D--FAADLI -----NNPTKFYYQAEYALREFDPL------------VE----N--------AELRIT-- --GY--P--N---QTSIRNLR--AKDINTLVGIDGIISKVTEVKPKFTVVVFQ--CEH-- DGH---EVSV---F--Q---P-DE--SFTS---TTCP----D----C--GSE--L-SE-- -----------SHVSY------TESSLLDYQKVQMQETPENVLGGDNPQAIDITL-IGDI TG-----DFSPGDRVVATGILRGNM---STVGN----KQKKSILDTYVQGFSLTKEQ--Q DFEELIITDSDETRIEELADSYDIYERLSQSIAPSIYG--YENEKLALALQLFSGV-TKH VDDGNSRLRGDIHILFVGDPGTAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQIIRYVKQ-LAPRGV LTSGKGSSAAGITAAAVRDSDFGGSDKWTLQAGALVLADKGVACVDELDKMESNDRAALL EALEQQTVSVNKAGINATLRSRCSLLAAANPSKGRFEEH-VVISEQID---LEPPLISRF DLIFVVTDDADEEVDSEISSHILNTN---KLGQQI-A----------------------- ---SEPTESST--------DNRNNEPTNGKEIIDADLFRKYVAHARKTNTPI-LSPEAES LIQDFYVQIRSD-----G-----SEDGR--IPITARKLESIIRLSEASARVRLSDTIKKS DAQRAINIVRMSLQQS-GVDPETG------------------------------------ ------------------------------------------------------------ ---------- ;AAA family ATPase n=3 Tax=Nanoarchaeota archaeon TaxID=2026764 RepID=A0A497I6P3_9ARCH 61Nanoarchaeota_archaeon__UniRef50_A0A497I6P3 ----------------------------------------MEKEEIIRRAVEFI--EQ-- -N-------YLKELSEVAMSDE-----KFS-LVIDF-EKLDKF-D--P---E--LAELLL -----DDAERVIEGFNAAVEETEIL-----------EEGQP-----------PKVRFT-- --NL--P--E-TSKVKISNIR--SSHIGKLIVISGIIRMATDVRPTLVVGTFQ--CPS-- CGT---LIDV--PQ------D-DV--KLKK-P-ELCP--------SC--GKR--GR---- -----------FKIVK------KE--FVDTQKITIEESPEALEGGEQPKRIDAFL-KEDL VHPKMQKSITPGSKIELVGVVKETP---TYVRG----GEST-RFDLFIEANNVTPIE--R EFEEIEITKEDEKKIRELSKDKDLNTKLINSVAPTIYG--YDEIKESIVLQLFGGV-RKK RPDG-TWTRGDIHILLVGDPGTAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLRYVSN-IAPKAR YVSGKGASGAGLTATVTKD-DFAGGG-WILEAGALPLTNKGIVCVDEIDKMEKHDTVAMH EAMEQQTISIAKANVHATLRCETTVLAAANPRLGRFDPR-EPLADQID---LPPPLINRF DLIYTIRDVPSKTSDEKLARYVLSIH-----ENP-------------------------- --------------------------EAVEPAIDKDTLRKYIAYAKTHVQPK-LTKAAED KIVEYFVKLRNR------RVNVEEEIRK--IPISPRQLEALIRMAEASARIRLSEEVTAE DAERAIRLLSESLKEV-AMD-ETG-EFDIDRV-TGHS---AEKRSKTYKVRDVIN-SLTA ----TYK---D-GVSVRMIIETAQEM-GV-DPK--DTEKILNELA-RVGEIYEPKP-GYI KKSF------ ;Putative ATPase involved in replication control, Cdc46/Mcm family n=4 Tax=Euryarchaeota TaxID=28890 RepID=L0HPR8_ACIS0 62Euryarchaeota__UniRef50_L0HPR8 --------------------------------------MEYLEEEIRSMWYDFF--SH-- TD-------YGTRLSEIADEYPD----TRS-LYVQF-EDLENY-N--P---S--VAEDFL -----KNPDVYLREGEKAIREYL------------HDPNLK-----------IHLRIN-- --QL--P--R-DRKREIRELR--AVHIGQFLSIEGIIRRASEVRPKLKVGAFR--CSD-- CGG---ITEV--EQ------E-GA--KLQE-P-FACS--------QC--NKTKPKVK--- -----------FKLII------EKSTFVDTQRAEIQDNPENLRGREQPQRLMAYL-EDDI AG-----EIVPGDRVVLNGILRTVE---RRLGN----VRTT-DFDIYLDVVSIDKES--K ELESIEITEEDEIRIREEARNGDIIERMKRAIAPTIYG--MDIEKEALLLQMFGGV-TKR MKDG-TRIRGDIHILLVGDPGTAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLQYMAQ-LAPRGI YTSGKGSSAAGLTATAVRD-ET--GR-WTLEAGALVLADLGLAAIDEIDKMNPTDRDSIY QAMEQQIIAVTKAGIYATLMARCSILGAANPKYGRFDIS-KPIVEQID---LPTPLLSRF DVIFKIIDKPNAERDRALANHILEAH---LAGEM-------------------------- ---------LEL------EEEDNIVVKQFDVGMSPDFIRKYVAYAKRNVVPK-MSDEAKK LILDKYVNTRKQ----------FEETRA--VPITPRQLEAMIRLAEASARARLSDIVTRE DAERAIKIIDYFLKEA---SSEEG-IIDADLLYSGIS---SRQRSVMERMEDIIR-ALAR ----DNN---G-MAEEKAIIAQAVAD-GI-EES--RARNILRKMH-QQGIIVQQRE-GVY RYVSP----- ;Minichromosome maintenance _MCM_ protein n=1 Tax=Methanomassiliicoccus intestinalis _strain Issoire-Mx1_ TaxID=1295009 RepID=R9T9M0_METII 67Methanomassiliicoccus_intestinalis__strain_Issoire-Mx1___UniRef50_R9T9M0 ------------------MTALESDITELQEKNSSVRYYTQEDASLESKWESFL--TL-- -A-------YTSELSEIVAGFPN----IRS-VYVDF-SDLDKF-D--P---D--LASAVL -----EDPDRALDAASRIIKKTYPL-----------TFGGLKDE--------LHVRIT-- --SL--P--N-DVKIPISHIR--TCHLGDLISVEGIIRKSTAVKPYITESVYQ--CRI-- CGN---KIHI--IQ-----DD-AR--KYTE-P-TECPRSEDG----C--GKA--GAKN-- -----------FKLLY------KETAFLDNQKIEIQEAPDSVRSGAQPASIIAYL-DDDA VG-----SVTAGDRVTLNGILRAEH-----KSQ----AMTP-QCDLYLDVLSVETQQ--D VYEEIEITDDDIAEIKTISQSPTLYKDLVASVSTTICG--YDVEKLALVLQLFGGV-PKT LDDG-SRVRGDIHILLIGDPGVAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQMLRYIAK-MSPRGI YASGKSSTSAGLCATAVKD-DFGEGR-WTLEAGALVLADQGNACIDEMDKMRDEDRSSMH EAMESQTISIAKAGITAQLNSRASVLGAANPKFGRFEDT-IPFSEQID---MPPALLSRF DLIFVIIDKPDEARDRSTSTHIISTH---RRGSA-------------------------- -------RQQRNDLEGVDLQKILNDTETLKPVYDRQIMRKYIAYAK-NIFPV-LTDKAAD LIQDAYMKIRQQ-----G----YGNNSS--VPITARQLEAYIRLAEASARARLSNIATEE DAQRAISLIEYYLQKI---AGQSG-TLDIDHIATGIT---KQKRNTLAVVSEIIH-NFES ----------R-TFSDDDVLENGLEH-GI-PAE--SISNILASMC-KLREIRHLGG-GIY ERLR------ ;Minichromosome maintenance protein MCM _Fragment_ n=1 Tax=Candidatus Heimdallarchaeota archaeon TaxID=2026747 RepID=A0A523X553_9ARCH 68Candidatus_Heimdallarchaeota_archaeon__UniRef50_A0A523X553 ------------------------------------------MSIKADDFKDFL--KF-- ---------YLEKSDKSLVGVF-----PKT-IVIDY-KDLDEW-N--P---K--IAEELI -----KNPDNVLDEIEKATKNHSKE------------------R--------VPVSIT-- --NL--P--K---AVGLSKLG--SKYLGKLILLKGIVNRVIPIRPMVMVAVYE--CKK-- CGE---RKHE--QQ------E-EY--FLVP-P-IKCGINK------C--RSR--K----- -----------FRFLE------GESEFIDVQELSIQEKPEDLSAGQLPSRVNLEIQREDL VN-----GARAGDIVDIIGILRTKP---SSSST-----KKR-KFAMFVDVNYIEAFN--K EVSEMKITIEEEQEIVSLGMRGDIYELIIQSIAPSIYG--NHHIKEAIMYLLFGGV-EKD KGD--IKIRGELNILLVGDPATAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLQVTAS-ISPRGL YTSGRGTTAAGLTAAVNKV-E---GDIWALEAGAMVLADKGICCIDEIDKMNDNDRVAIH EAMEQHKVSINKAGINARLNARTAVLAAANPDFGRYDPN-KTVTEQIT--KLPVTLLSRF DLIFLMRDKLKADQDAELSAHILEIG---ERKKV-------------------------- ------------------------------EMIPRDLMKKYIAYAR-GIKPV-MTDGAKN YLSNFYQEMRKV-------SHNRIEDVP--VSITPRQLESLMRITEAHAKIALKAEADES DAEAAIKIMKISLNEI-GINPETG-KLDVDIITTGIP---KTTRDKF---------RL-- ----------------------------V------------------------------- ---------- ;MCM domain-containing protein n=1 Tax=Thermoplasmatales archaeon ex4484_6 TaxID=2012524 RepID=A0A256Z4C2_9EURY 71Thermoplasmatales_archaeon_ex4484_6__UniRef50_A0A256Z4C2 ------------------------MVTIPGMYGSLTMERYMDDETAYQLWLDFF--SV-- ------TD-MSTRIKSIADKYP----EIRS-VEINF-SDIYRV----NG--D--LAESVL -----DRPEMMIRLGESAVHSLLDP----------DQRVV------------INLRIR-- --DL--F--K-NDKIPIRDLR--AENLSKFISIEGIVRKVTEVRPKLLIGVFS--CSS-- CGF---KQEI---E--Q---D-PF--HFKE-P-LECPKDEGG----C--GKRAGS-T--- -------T---FRFNI------ADSIFIDSQKIEVQEFPEGLRGGDQPQRISIML-EDDL CG-----KVAPGDRISVTGVLKAKQ---RKEGQ----VKGT-VFDIYLFGNCIDSND--Q VYDDMELTNEDIEEAQKLAKDMHIFTKIKSSIAPSIFG--LDHIKESLALQLFGGV-AKE YPDG-SRGRGDIHLLLVGDPGTAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLTYMST-LAPRGI FTSGKSASAAGLTAAVVKD-DFGEGR-YTLEAGVMVLADMGLACIDEMDKMTESDRSAMH EAMEQQTVSIAKAGIQATLQSRCSVLGAANPKQGRFRMG-QPKHEQIN---LPPPLRSRF DLIFTMTDEPRVEEDRKLAKAVLEMH---WLGEL-------------------------- ----KMSEATGDTRLKRMIEEGSDIVDRAMPVIEAEKLRKYVAYARRVCFPV-LSDEARQ EIMDFYVNLRAE-NASFG----GEGGGS--VALTARQLEALVRMAEASARTRLAQTVSRQ DARTAIELMRYSLRDI--ALTDSG-TYDIDGVMGSGF---KSQKDRMYDIVRLIK---EQ ----SRD---G-RIKRKDLVIHAAEL-NI-EER--ELDNYLRKLQ-DEGAIFEPRS-GEY SVL------- ;MCM family protein n=1 Tax=mine drainage metagenome TaxID=410659 RepID=D6GVP3_9ZZZZ 77mine_drainage_metagenome__UniRef50_D6GVP3 -----------------------------------------MKNELDGIISNFV--NK-- -R-------LSENIKEVLTTN------KNA-IVLDF-DEIDQF-S--P---E--LGDSVL -----KQPEETLDTIKYFVNETSIP-----------HKALD-----------IEIRVK-- --NL--PKNA---QMLVREIR--SKHIGLLVQVQGLIKTAASVRPVASAIDFE--CQS-- CGH---ITKV---E------Q-KD--MTQKAP-SICT--------NC--GKK--G----- ------------RFKS------VKKYLVDTQRITLEEAPEDLEGGEQPEHINIIL-KKDL VDPKFERNIIPGNKVIVSGIINESAI--YYPSG----KRSN-TSDTFISASFVEAVE--Q GYEDVLVTKEEEMAIRELANDKMIYNKLKNSIAPNIYG--HDNIKEAIVLQLFGGV-RKI AASGNSVIRGDMHILLVGDPGTSK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SSMLKYIAG-IAPKAR YVVGMGSSAAGLTATIVKD-DAT-RS-YILEAGALPLTNKGLLMIDELDKMNKDDRVAMH EALEQQTISISKANIHATLSAQTSVLAAANPKMGRFNPF-DVISAQIE---LPPTLINRF DLIFILKDRPDKETDMLIAQRILEAN----KDIN-------------------------- ---------------------------KNKPEIPPNIMKKYIAFAKQNIKPK-LSMEAMK AIEEFYLKLRAQ------YSTEGDEVKP--IPISARQLEAIVRLTEASAKVKLSDYATLE DAKRAIDLMMSYLGDV-GVDSSTG-QLDIDRIITGIP---SSQRNTALTIKSIIKSEVDN ----MPM---GSAVALSKIYDAAEKV-GI-DNE--KVDAAITVLK-KEGEIFEPKP-SFI KLL------- ;ATPase involved in replication control Cdc46/Mcm family n=1 Tax=Candidatus Methanohalarchaeum thermophilum TaxID=1903181 RepID=A0A1Q6DWB2_9EURY 78Candidatus_Methanohalarchaeum_thermophilum__UniRef50_A0A1Q6DWB2 ---------------------------------MNNRISVDDEEGLKEVVEEFL--DR-Y YDSQGTEF-TLRDLIE---SYP-----GRKHLSIDY-KRLEFF-D--P---D--LADLLL -----VEP-LVIDELEKKAREMALE---------KYDANLD--K------G-FNVRVK-- --NL--P--D-DIYLQIRNIR--QHHINRFFPIDGIVQKATQVMPQATLAVFK--CEE-- CHE---IMEI---R--QK--S-ET--EFKS-P-PKCYNEK------C--GAG--S-S--- -------K---IEFLE------KKSEFRDFQKIKIQEPPEQLTGGEKPEDITVKA-KDDL AG-----KVTPGNRVTVNGFVKIEK---RENSR---------IYDPYVEANNIELEE--Q EFQRIEISSGDEEKIRKLSEDPQIYSKIIESMVPAVYG--YSNIKEAVALQLFSGQ-PKK NPDG-TRIRGDIHTLLIGDPGTAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQILRYISD-LAPRGV YASGKSVSAAGLTAAAVKD-EFSEGA-FTLEAGALVLSDQGVCAIDEFDKIEAEDLNALN DAMEQQEIAVHKAGIDSTLKTRCAVLSAANPKYGRFDEF-EPIPEQLN---IDPTLLSRF DLIFPITDKPDRDRDNRIAEHILNTN---RLGEK-------------------------- -------RKREEVMDRNIVDEGDAEVVRVKSEIEPDLLRKYVAKARQ-ISPV-MTQEARD KLKEFYIELRNE-RWDSSS---SVDEDP--LPITARNLEALIRLGEASARTRLSDKVKLK DAERAIRIVDNCLSKVKESYSESNVSLDTIEVKKEEN---LSMTEKVSNVLDVIEKEFEG ------------EAEENELIHKMKELMGIEDTE--KAKKLIERAK-KENRIYEPRD-QVY KIV------- ;NEQ282 n=1 Tax=Nanoarchaeum equitans _strain Kin4-M_ TaxID=228908 RepID=Q74MT7_NANEQ 81Nanoarchaeum_equitans__strain_Kin4-M___UniRef50_Q74MT7 -----------------------------------------MEELEKLELEKYL--LK-- ---------KMNEANDI--------------LYISL-KELEEL-GLIN------LIDEIL -----DNPEKAIEQIKTIVKEIQEE------------YALTKVD--------YYIAFT-- --DV-----QYYRNVKIRELR--SHHLNKLVAIEGIIKQSSMVKPVLKRAVFR---HS-- CGY---EVEK------EIKSI-SD--KISK-P-KKCP--------KC--NKS--GD---- -----------WEIVE------EE--YIDIQRLVLEELPENLTGGAQPERVTAIL-KDKL VEPKINDKTVPGARVRIVGIPRTAK---LTEKG-------A-IYDILIEVNNIEFLE--K NITDIVITNKDLVEIKEIANSNNPLDLLVENFAPSIFG--YDYIKKAILLQMVGGV-KKI RRDG-TKVRGHIHILLVGDPGTAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------STLLKYAAE-VAPRGR YVSGTSATAVGLVAVVVRD-ELL--KVWSIDAGPMVLANGGLLALDEIEKLGKNELMILH EAMEQGSVTISKAGIHVTLKTETSVLAAANPKFGRWDDN-LSLVEQIA---IPPTILNRF DLIFLIRDKPGKDYDEQLAERVLESY---------------------------------- -------------------------VEDVDLAIPVDLLRKYILYVRKNIKPR-LSNEAIA RIKDFFVSLREK----------SQELKA--VPISTRQLESIVRLAEASARIRFSDIVEKE DADLAIELTKRFLEEA-GVDPESK-VIDITILESGKP---RSKIEKQKLLLQLIK-QL-- ----DSG---E-GVSEKELIEKAKEY-GL-MDS--EIEQLLYYLK-TSGAVFEIKP-GIL KAV------- ;MCM domain-containing protein n=3 Tax=Candidatus Woesearchaeota TaxID=1801616 RepID=A0A1J4XUW3_9ARCH 89Candidatus_Woesearchaeota__UniRef50_A0A1J4XUW3 ---------------------------------------MMETGEQIGLFKEFF--EQ-- -Q-------YSLDLAE-IQRLG-----KRR-MSVDF-GAIATH-S--V---E--LAEMLM -----DQPEEVIKAAELAIQEVLGL-----------DEPV------------VAVRLI-- --NV--PYTQ---KYMVRSVR--AEHIGRLIYLEGIIRQKSDVRPQMTLARFE--CPA-- CGN---VTSI---P--Q---T-DT--TLKA-P-GRCS---------C--GYK--GT---- -----------FRQVS------KE--LVDAQSIVLEESPDELEGGEQPKRINLFL-RSDL VSPLSEKRTNPGSRIGVVGILKESPQ--MTKAG----QKST-RYDIFFDVNNIIPKD--E TFEDVKITDEEEETFRELAADPHLWDRLVASLAPSIYG--HEKVKLALLLQMFSGV-RKR REGG-VVIRGDIHVLLVGDPGAGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLRRVAA-VAPKAR YVAGKGASGAGLTAAVVKD-EFIRG--WALEAGALVLANEGMCMIDELDKMSTEDRDAMH EALEQQTVSIAKANIQATLRAETTVLAAANPKYGRFVIT-ESLPGQVD---LIPSLLSRF DLLFAIKDLPDPGRDAEMAGFILNMH----RTTK-------------------------- ---------------------------HESPDIPTPVLKKYIAFARR-FQPK-LTEAAFN EIKDYYVSMRSK-----GL---EGETKS--VPITPRQLEALVRLSEAAAKARFSDLVEQQ DAKIATDLVQYYLNEF-GRDSSTG-VVDIDRIMTGTP---ASQRNKLLIVRDIIR-NLLS ----RSG---EKEVLVTDIYMEAQEK-NL-GEQ--EIDDLLVQLE-RKGDIWKPSK-NKV STM------- ;DNA replicative helicase MCM subunit Mcm2 n=1 Tax=Aciduliprofundum sp. TaxID=2060325 RepID=A0A2J6WWY0_9EURY 90Aciduliprofundum_sp.__UniRef50_A0A2J6WWY0 ---------------------------------------MVNEDEIRELWDLFI--MQ-- ------YG-YNLKISMLSEKYP----EERS-IQVDF-MEIQEF----SQ--E--LLESLT -----SNPEETIAIGEDVIIK-KFP----------EEQKVE--I--------LHLRLK-- --NI--P--D-DRLKEIRKIR--SKNIGELITIEGLVRQVTEVRPKLVTGAFE--CTS-- CGH---VNYK---E--Q---E-TE--TLEF-P-VFCE----G----C--GKKKGE-T--- -------R---FKLLE------DFSVFVDSQKIEVQENPEDIRGGEQPQRIQVYL-EDDL TG-----IVVPGDRVRITGILKTRP---RGTKQ----FPST-IFDIYLYAINVESIK--E EYKSVTLTEEDVERIREFAQDKNVIKKLSDKIASTLFG--LEIEKEAILLQLFGGV-PLK RRDG-TRIRGDIHILLVGDPGTGK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------SQLLKYVTN-IAPKSI YTSGKGSTAAGLTAAATKE-EFGEGR-WTLEAGALVLADNGIAAIDEIDKMDDKDRVAMH EAMEQQTITISKAGMNATLMARCSILAAANPKFGRFDIS-RPLSDQLN---LPPTLLSRF DAIFKMPDVPG-DMDARIADHILDVH-MEKEGEQ-------------------------- ------------------------------EEIDDEFFKKYIAYAKKHIIPK-IMPDARE ELKQYYLRMRNL-----YN---QTSAKS--IPITARQMEALIRLTQASARARLSNIATAE DARRAIRIIQHFIEDI-ATTPE-G-TIDIDRVMGTIP---SSERSKYETVVDIIK-DLST ------GK--G-YAGEDEIVREAKVRAGI-DDF--ELRKIIQALM-RDNIIFMPYN-GRY RLIE------ ;ATP-dependent DNA helicase MCM n=2 Tax=Halobacteriaceae TaxID=2236 RepID=A0A0U5H882_9EURY 91Halobacteriaceae__UniRef50_A0A0U5H882 -------------------------------------MAQAANQELVDLFEEFY--RR-- -Y-------YSDDVAELAREYPRE---SKS-LELDW-RDLYQM-D--P---D--LADDYI -----NHPDDLREAAEEALRLYDLP------------VDVSLGR--------AHVRVH-- --NV--S--E---TVPMEDID--SGTINTLVSVTGTVDTAHSTQSIVERAVFV--CQR-- CGM---ETEV---P--QPGHT-DG--DLQQ-P-YQCE--------SC--ERQ--G-P--- -----------FKLDS------DRSKWVDQQKFKLRESPIGDKNGKDIESILAFA-EDDI TG-----TVDPGDQITVVGVVRMKD---PGEYT-----AAS-ISDKYIEVSSIEPAD--- PLEEIEISTSEEQQITDLANTSDVIERLCDSFAPSVHG--YEEQKLALLLQLFGGV-DKD LPDG-AQIRGDIHVFLVGDPGSAK------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ ------------------------------------------------------------ --------------------------------------------TRLLQATTK-LAPKAL RTNGTRTTSAGLTAAATRT-SDGTSA-WELEAGPVVLADEGHLAVDDLDHMPEEVSANLY EPMEEQTVSVSKGDANDVLSARTSITAAANPKYGRFDQY-EPLGEQIN---LPPALMSRF DLIFTHIDSVDEAGDSEVASHILDVN---HVGELR-A----------------------Q -----NLSTES--------ETEDDLRKSVEPEIELSLLRKYIAYARRNCVPT-LTPEAKE TIEEFYVDLRSN-----G----ADEDAP--VPVSARQLEAIVRLAEASARMRLSDTVDQE DADRVVALARSALQDI-GVDPETG-SFDADVVEQGKS---GEQMETEDVICRIVG-QLEE ----EYD---E-GAPIEAVVKHAEQR-GV-SAE--KAQHVLEKQK-EKGEMYQPNA-DHL RSI------- ;no comment 1_lcl|ORF1 ---------------------------------------MSNADDVTDFFQRFF--TE-Y KDDDGNFK-YTNRINRMVRDG------SQY-LQIDY-DDVLLY-E--AGDGD--ISTPLF -----ENPYFVMDYANMALGEAVRQ------ESVDFYNDMNRDG------VDFMIQFV-- --DL--P--I---EIGLRDLR--AKHVRTMRVIEGIVTRTTDIKGIIREAQFF--CKE-- NREHIVVMTL----------L-DG--IYSS-P-NQCSVPT------C--RSK--Q----- -----------FSLEM------EFSSQVDWQLVTLQEMPENISAGRTPVSIRCRF-TQGM VG-----SANPGNRIAVTGVIRAQS--RKTIQK----GKIM-LLDKWIDTNHVKVLGYQQ KYEE--ILPAELKEFDEMAKDPKLFDKLVNSFAPTIYG--LKEVKAALLLFLLGGV-DKI RADG-IKLRGQSNILLVGDPSMGKCCRGATTYVFSNRGMKLLSDFYQTDEIESDKEFSLG IETFDFQSFNPKNTVAIYQRKQA----------------KTIKITNSIGLAIEGTPHHRI -------IIQNNTGDIEWKQLQDIQESDHIVIRVGSNLFNKSHKKITFSSPIQKIKNTKK ITIPKTMNMDLAYYISLL-------------IGDGCLTK-------K------------- ---------------RCIEFTNADKYLLDQFEKLSLDLFGLIGFVQLKKGSIASTVVISS VTLQRFFDYLGLG-GKYSFEKTIPQLILESPKSVQIACLKGLFDTDGEISKYDVAYT--- --STSELLVIQVQLILLNLGIVTSKKTKT----------TTHRDLYRLRIVGAYIPLFKE LIGFRCTQKRTALDKTKARNKTNVCGVPNIQRHLYKLWYSIPEEVRYKNGYKKGSKASIG GVTFTYLRRYFLKSQNRNIPVYKLGSLLEGFAKLYPKITQLKEYKKLTVFTKGMF----- ------------------------------------------------------------ ---------FTKLAHKTTGIADVMDFTIPDTESFTANG-IINHNSILLKYTKS-LSDRAI FTSGKGSTAAGLTAAMLRD-PDT-GE-FNLEAGAIVLADEGYVCIDEFDKMSENDRSAIH EAMEQHQVSISKAGIVTTLNARTGILAAANPKYGRYESH-RTFMENVN---LPPTILSRF DLIFPLLDDPKQRDDAARVEYILASH----RMET-------------------------- -------------------------IAKTTETYSTAVMQKYIAYAKSTSSPI-LSESAEQ AIFEFYINLREQ---------IGDDKGR--IPITDRQLESIIRLAEARAKINLKKTVSKQ DALKAIQLVQYCLEQV-TTDPETG-KLDIDFMYSGESSTKRTTRNKMEKIMALLS-FFQR ----TYS---G-PFSEEEFLKEAENE-GL-TQE--YTIAVLEQLK-RDGKIYTPTP-GRL KLAS------ ;helix-turn-helix domain-containing protein [Thermococcus barossii] 2Thermococcus_barossii_WP_088864037.1 ----------------------------------------MDREDMIERYARFL--RE-Y VDDSGNEV-YLNKLKDLLTVTP-----KRS-LAIDW-THLNSF-D--P---E--LAAELL -----ENPEESILAAEDAIQIVLRE------PPLLKEEEFK-----------VHARFY-- --NL--P--R---TLLVKELG--SEHINRLIQVEGIITRVSEVKPFVEKAVFV--CKD-- CGN--EMVRL-QRP--------YE--NIVK-P-SKCD--------AC--GSR--N----- -----------VDLDV------EKSRFINFQSFRLQDRPESLKGGQMPRFVDAIL-LDDL VD-----TALPGDRVLVTGILRVIL-----EQK----DKRP-IFKKVLEVNHIEQLS--K EIEELEISPEDEQKIRELAKRKDIVDAIVDSIAPAIWG--HKTVKKGIALALFGGV-QRT LPDG-TKLRGESHVLLVGDPGVAKCVDYHTKVILADGSLREIGDVVEEAVEKANSMGTLG KVDDGFYAPIDLELYALDAKTLKVRKVRANIAWKRTAPRKMYRIRTASGREIRATPTHPF -------FTFE-DGQFRTRRAAELKEGYFIAVPRTIPVDGR-PVKLSEVPIEKPKTAKSR LKLPEFADEEFWYVIGLL-------------TGEGYTQKRGS----S------------- ---------------ATVYFTNNDDRLIEKVYEYFKKLGLNPTIRDSHKGKTAKEVYASG IELYQLMKWL--GIAQNSSEKKVPPQLFGARLEDVRAFLRGHFDAEATVDRKRPKIT--- VVSASEELLKGVQHLLLRFGIKSQLHETRSRATNGRM--KTARKYYRLFITGEDAVRFKE LIGLEVSRKHKILEQVTQGIKP-NTNVD-----------IVPGVGKLLRKLRSEAGLTQK QMGINRSTYMHYERGDRLPSREKLKIVIEALKRRLSESE--------------------- ----------------------------------------------------ELKVLELL ASSDIFWDRVVEIEEYNPEHPWVYDLQVPEHHNFIAND-IFVHNSQILRYVAN-LAPRAI YTSGKSSSAAGLTAAAVRD-EFT-GS-WVLEAGVLVLADGGFALIDEFDKMSDRDRSAIH EALEQQTISISKAGITATLNARTTVIAAANPKYGRFNRH-KSLPEQLD---LPPTLLSRF DLIFLLLDEPDEKVDASIAEHILKVR----RGEA-------------------------- --------------------------EAVTPKIPYDLLKKYIAYARKNVHPV-LSREAME EIKRYYVRMRKG-FKRPGE---EDGVQP--IPITARQLEALIRLSEAHARMRLSETVTRE DAKAAIAIIEDMIRKI-AVD-EEG-TLDVSILEVGKS---SKKINKIDRMVDIIK-SLES ----EGE---F-GAPEDRIIEAAKQA-GLGSEN--EIKKLLNDLK-RDARIYEPRA-GFY RVL------- ;hypothetical cell division control protein [Thermococcus onnurineus NA1] 3Thermococcus_onnurineus_NA1_ACJ15527.1 ----------------------------------------MDREDMIERYARFL--RE-Y VDDSGNEV-YLNKLKDLLTVTP-----RRS-LSIDW-THLNSF-D--P---E--LAEELL -----KNPEDSILAAEDAIQIVLRE------PPLLREEEFK-----------VHARFF-- --NL--P--R---TLLVKELG--SEHINRLIQVDGIITRVSEVKPFVEKAVFV--CKD-- CGN--EMVRL--QR------P-YD--NIVK-P-SKCD--------AC--GSR--N----- -----------VELDV------EKSRFINFQSFRLQDRPESLKGGQMPRFIDAIL-LDDL VD-----TALPGDRVLVTGILRVIL-----EQK----DKRP-IFKKVLEVNHIEQLS--K EIEELEITPEDEQKIRELAKRKDIVDAIVDSIAPAIWG--HKTVKKGIALALFGGV-QRV LPDG-TKLRGESHVLLVGDPGVAKCVDYDTQVVLADGSLGKIGELVEGAIRRAKKEGTLG RVDDGFYAPIDLELYALDAKTLKVKKVKANIAWKRTAPERMFLIRTASGREIRVTPTHPF -------FVFE-NGQFKTRKAEELKASDFIAVPRIIPVAGK-PTRLWDIEIEKPKTAKSR LKLPEFADEEFWYVIGLL-------------AGEGYAQNRNG----S------------- ---------------ATIFFTNNDEKLIQKVYEYFRKLDLNPTIRKPHRGKSAKEVYVSS VEFFRLFKHL--GIAENSSKKKVPSQIFSARLEDIKAFLQGYFDAEGTVDRARPKIT--- VVSASLELLRGVRHLLLRFGIKSQLHATRGIATNGKM--KEAKTYYRLVITGKDVIKFRE TIGFGVEEKAKLLAKVTNGIKL-NTNVD-----------VVPGVSKLLRELRESAGLRQK DLGINRSTYLHYERGDRLPSREKLKIVVETLKEKSPD----------------------- -------------------------------------------------APKKLKVLELL ADSDIFWDRVVEVREYKPEHPWVYDLQVPEHHNFIAND-IFVHNSQILRYVAN-LAPRAI YTSGKSSSAAGLTAAAVRD-EFT-GS-WVLEAGVLVLADGGFALIDEFDKMSDRDRSAIH EALEQQTISISKAGITATLNSRTTVIAAANPKYGRFNRH-KSLPEQLD---LPPTLLSRF DLIFLLLDEPDEKIDASIAEHILKVR----RGEA-------------------------- --------------------------EAVTPKIPYDLLKKYIAYARKNIHPV-LSKEAMD EIKRYYVRMRKG-FRKSGE---DEGVQP--IPITARQLEALIRLSEAHARMRLSETVTRE DARAAIQIIEEMIRKI-ATD-EEG-TLDVSILEVGKS---SKKINKIDKLIDIIK-SLES ----EGE---F-GAPEDKVVEAAKQA-GIGTEN--EVKKLINDLK-RDARIYEPRA-GFY RVL------- ;hypothetical protein DRJ40_00460 [Thermoprotei archaeon] 5Thermoprotei_archaeon_RLE57724.1 -------------------------MATSGEAPELSIITPKPPETIGERFLNFL--KSYY TP-EEGYK-YRARIARLIAEN------SKS-LVVDF-PDLLTY-D--S---S--LAELIV -----EKPLEVIPVLSEALREAIKI------EDSEYAQKHKK----------FNVRFR-- --KL--P--E---VVSIRRLR--AHHIDKLIMVEGIVTRATPVKHQLIKAIFR--CKA-- CGT---EIEV---P------QVAA--HFVT-P-TKCPNE------AC--PSR--RGP--- -----------FELIE------EKCEYIDWQKIVIQEKPEDLPPGQLPRSLEAIL-IDDL VD-----TVKPGDRVVAIGVLRIQQ---ESLKK----SKPP-VFSAYLDINYIEAQT--K EFAEVEITPEDEKKILELAKDPRIKERIVKSIAPSIHG--MRPIKEAIACLLFGGV-PKV YPDG-VRVRGDIHILLVGDPGTGKSLTYSVPVLYYEPGKGLQFRPIGEIVDTLIEQYRNR VKVEGESEILYLRDVGVEIYVPSVNPEDFTVEWKKVRAVIRHRAPEKVVLVKTKTGRTIV -------VTKDHSILVFNGSKLAVARAQDLIPGKSIVPVLR-RILPVSTEKLTNFHGMQL DWDIGYLVGMFLGDGTIA-------------KVTSGERFELTSLDPN------------- ---------------VLVKISEILQNKFSTICSLHIHDSRSMTYKLICQRDAVVEWLKQF IRDKHALHREKVKGYETRLKYVPYELLLNGPEEFVAGFISGLLESDGYIAIPRVKECGKS HHGEISLTLVNRELATAFSLALTRLGIWHSLRTGVKLYKGKELMVYTIRVLDISKLKSVV QLISEDKMLRLAQVAEPRTTDDIVPVPR-----------ELVREISLLGFCRGRLRSLGS EFRGKVYRGYVGRAYAHRMVQKLMERAKVTECGELSGIQKLA------------------ -------------------------------------------------RFLENEYLGWD LVAEVKEVSISEVEPEHSEYVYDLSVEDYENFVAGYGL-IFVHNSQLLKFVAR-VAPRGV YTTGKGSTAAGLTAAVVRD-KAT-GE-YYLEAGALVLADGGVCCIDELEKMESRDRVAIH EAMEQQTISIAKAGIVATLNARCAILAAANPAYGRYLPN-RTLAENID---LPVTILSRF DLIFIIRDEPEQSRDTALARHITMLH----QGATP------------------------- --------------------------EEFRDIIPPDLLRKYIAYARKYVKPK-LSPEAAR RIEQFFLELRRQ-----S----QGPNSP--IAITARQLEALIRLAEAEARMALRPVVTLE DAEAAIRLMMEFLKSA-GMDLSSG-TLDIDIVMAGRP---RSQQEKLARLMDIIK-SMEE ----EKG-----KVKVSELIKRAEEE-GI-DRE--FVEKAIETLK-RQGELYEPKP-GYI KRVKV----- ;helix-turn-helix domain-containing protein [Ferroglobus placidus] 6Ferroglobus_placidus_WP_012965487.1 -------------------------------------MIKMFSSP--GVWREFF--ET-- -Y-------YRDEINKLAGKKLS--GVKGS-LYVDVTRDLLIFRE--G---K--LAEELF -----ENPEVVISHAEQGLASAENI------------YDVSLEG--------CKVRFV-- --NL--P--A-SRRILIRDLR--AEHISKFVSIEGIVRKVTEVRPRIVKALFI--CTN-- CGK---ELLV---D--Q---E-EN--VVKP-P-SECR----A----C--HSR--G-R--- -----------FLLVP------EKSVSVDSQRVKIQEYPENLRGGEQPQIIDVLL-EEDI AG-----SITPGDRVIINGIVKAVP---RGAGK-----KLV-HMDLQIYGNSVEVLQ--Q EYEEFEITEEDKKRILELSEDPNIYDKIVRSIAPSIYG--YDDIKLAIALQLFGGV-PKR LPDG-TEIRGDIHILLVGDPGVAKCVDYDTEVLLSDGSLVKIGDLVNNEIKNGKVKKIDD GVYVETNLDIISLDSRFLKSRTS----KANIVWKREAPETMYKIKTKTGRTVKVTPTHPF -------FTIK-NGKFVTVKAKDLKKGDLIATPRIIPVFGS-PQPLPDSFERSKSNNAVR LKLPERTSPEFWRFIALF-------------MAEGYAQRSES----G------------- ---------------ATIFFTNNDEKLVSEFFTYAKKLGLNPSLRKPHKDKRAKEVVVSS VELYNFLELI--GVVGKSKDKKIPDLLFRCSKEEIKAFLSAFFDAEASVDKKRPKIT--- VVSASQELLRQIQHLLLRFGIISQLHETKSRATNSQK--PKKRTYFRLTITGENALKFVK EIGFTVNSKLREWKIKK------NPNLD-----------VVPKVSGILKETRKLLDLTQS ECGVKRSTYQHLERGDRRPSRDTLKKVVKAFRKRLNGNKA-------------------- -------------------------------------------------AELNIRFLELL AESDIFWDEVTEISTYKPEHPFVYDLQVPEHHNFVAND-IFVHNSQLLRYVHR-IAPRSV YTTGKGTTTAGLTATAVRD-EID-GR-WTLEAGALVLADKGIALVDEIDKMRNEDRSALH EAMEQQTISVAKAGINATLKARCALLGAANPKYGRFDKY-TPIAEQID---LSPTLLSRF DLIFVMTDDPDEERDAALAKHILDTH---ELGEKL-A----------------------K FKNVVASGLSK--------EALEVESEKVKPVIEPELLRKYIAYAKRTVFPV-LTEEAKQ KIIEFYLSMRGR----------IKENSP--VPITARQLEALIRLAEASARIRLSDKITAE DVERVIRITKRSLEQI-AIDPETG-EIDIDYAFSGTS---KSQRDRILTIKKIVE-DLEK ----EFE---K-GVPEKEILEEAEKR-GI-DKA--KARELLYKMR-ERGELYCPRP-DHY RVVHSY---- ;cell division protein [Methanosarcinales archaeon] 7Methanosarcinales_archaeon_RLG34069.1 -----------------------------------------MQDLIAERWEDFL--KR-Y ---------YWNELIELSNSYPE----KRS-LFVKF-ADMDIY-D--P---D--IADMLL -----EDPDVAIEAATRALREIDIP------------TGVTLDE--------ANLRIT-- --KL--P--R---KVKIRDIR--SIDIGKLVSIEGLVTKATEVRPRVVEAVFE--CPF-- CGH---IFAV---E--Q---N-GR--QFKE-P-RECERESGG----C--GRK--VQR--- -----------FKLLV------DKCKFANAQKIRLQESPEELRGGELPQAIDVNL-EDDI SG-----EVSPGDRIIVIGILRSYQ---RSTQF----GKTP-FFDIYLDGNSLEIKE--E EFEEIEITEEDEREIMELKNQPDVYEKLIRSIAPSIYG--YEEIKEAMVLQLFAGI-PKE LPDE-TRVRGDIHLLLVGDPGVAKCVSGDTEILLSDGSLQDIRTIVDGAASKKISGSVDD GVYIETNHDLVSLGLNGKTVLSK-----GNLLWKRQATSKMYRILTSSGREIKVTPTHPF -------FVCGDDARLRGKKAEDLKVGDFIATPRKIDVFGA-HQPLNNDYGWSRRRKAVR LKLPSHTTPEFWRFIGLF-------------IAEGHLESRMHP---R------------- ---------------CTAFFINNSSQLMEEYRTYAKKLGLNPSYRDSLSGKTAKEINISG IEFGTLLEKL--GAAGQSRSKRVPELLFKCSTEEITAFLSALFDSDGTVSIKHRKIV--- ITSASKKLLSQVQHLLLRLGILSRLCPTSSAKATNTTPHPKKNGFYRLSITGEEIKKFET KVGFTVAEKIEKLKKLCASPCIHNTSID-----------VVPNLASLLKEIRLRLRLTQF ECGITRSSYQHYERGDRNPSRSSLHRVVQQFEKRAKCMDDMDDAVEL------------- -----------------------------------------------------LSALKAM LNSDIFWDRIEKIEDFVSEDEYVYDIQVPVYHNFVAND-IYVHNSQMLTFLVK-LAPRGL YTGGKSSTSAGLTAAAVRD-EFGEGR-WTLEAGALVLADRGIAAVDEIDKMEKKDRDALH EAMEQQTVSIAKAGIMARLNSRCALLAAANPKYGRFDKY-TPISEQIN---IPPTLMSRF DLIFTMMDRPNEEMDTKTAEHILEAH---YAGELH-A----------------------R LTSKGKVEEVEK-------EHFKRAMQTMEPSIPVDLLRKYVAWSKRNVFPV-MTEEAKN KFLDFYIGLRRQ-----GY---EDEEAP--VPVTARQLEALIRLGEAKARTRLSDKITAE DAERVINVVTHCLKHV-FVDPETG-KLDADWITVGTT---KTRRDRARSIRDIIK-ELEK ----EYG---D-EVPIEEVLDLAEEE-GI-ERE--KAEDIIEVMK-RDGILFSPGS-GVI KFVR------ ;hypothetical protein E4H14_03610 [Candidatus Thorarchaeota archaeon] 8Candidatus_Thorarchaeota_archaeon_TFH09900.1 ---------------------------------------MSSYDESQERFEEFL--RT-Y KDDQGTLI-YWTRLQQMSIND------ETS-ISIDF-QDLISF-D--N---V--FMALAA -----ENPSKFIETVNNALIAVLRV------EDPDYVSSIDTSL--------LKARIT-- --NY--S--E---HVPLRAIR--AKHIGKLVRVSGIMMRASEVKPLLVQAMFQ--CRI-- CDE---KIPQ--TQ------E-EG--RYTE-P-VRCP--------LC--DKK--T-P--- -----------MRLLA------QESQFRDWQKVRIQESPDELPPGQMPRSIDIIL-EGDI VD-----ISRPGDLVKVTGILETTP--DFSRRG----GRLA-TFNIFIEANGVEISE--K EHEQIEISEEDEKQIRELADDPYVHERIVASIAPSIQG--HTTIKESIALLLFGGV-SKT LADG-TKLRGKSNILMIGDPGTGKSIHGNESIFLGSTTDKGFKWTCKKIANVVDSLMNKY PGEIVHQDETEILQLSEDYDFHTMSLNPNSLKTQKSRIIEVSRHKTDKLIRVNTASGRSV LMTPNHSLTTLHNGCLKVLTAQDLNSNVYLPIARNIDFYDESIPLKVDIGEIFSENELVN ANIIHDQISYIGQNHGVV---QKAAKTANVTSTTMRMYINNPTAVPIGNWLRRKHDTSWF PNKVPLDERFGRIIGFYLSEGNIEKTMVRFTNFDKTIQKTIESDLKVLFGKASVFKRGVY ICQASICQWFLKMFDTGAGEKKLPDQFLTAPLGFRRSLLSAYFSGDGWVEEKSASVN--- ALSKSKELVYQLSDLLSTVGIFARIKKKKLQSGS-----YKNRMYYEIQINGEELFEFNR QIGFVSTTKQERLENLIDILSKRQRYQS---------HDIIPNFGKLCIQATNDVEISAK RGSPTRGFLGEIRGKTYRQRMGRKYLCNLIERMTEFRLKGT------------------- -------------------------------------------------HSDAMERLRIL SKSDIFWDKITKIEHIN-ENTVVYDVGTDNGHFIVANGNLIVHNSQILKFVAG-LAVRAL YTSGKGSSAAGLTAAVIHD-ADS-GA-MTLEAGALVLADQGIACIDEFDKMDPTDRTAIH EAMEQHTVSIAKAGIVATLNARTSILAAANPTLGRYESS-LSVQDNIR---LPFTILSRF DLIWIMVDTIEATRDRELAQFILNMH----QMKRS-K----------------------- -------------------------DAPLTPPVSQEFLKKYIGYANRYVIPQ-LTPEAAE VIENFYVDLRRS----------AEGGSA--VPITARQLESLVRLAEARAKMALQPKVSKE DAQAAIRLMEESLRMV-ALDRVTG-KIDIDKLVSRMS---ASQRSSSDIIIKAIR-DMES ----EGT---S-TVNKDALVQKAVSM-GL-AKE--QAEEVIEKLL-AEGILYSPRD-GKI RHSQN----- ;helix-turn-helix domain-containing protein [Haloarcula hispanica] 9Haloarcula_hispanica_WP_129755831.1 -------------------------------------MATAENTELIDRFEEFY--RN-- -Y-------YRNEIGELAQKYPND---QKS-LYIDW-DDLYRF-D--P---D--LADDYR -----TKPEQIQEYAEEALRLYDLP------------VDVSLGQ--------AHVRVR-- --NL--P--E---SEDIRDLR--HEHHGNLVAVRGIIRKATDVRPKVIEAAFE--CQR-- CGT---LTRI---P------QTAG--DFQE-P-HDCQ--------GC--ERQ--G-P--- -----------FRLNT------DQSQFIDAQKLRVQESPEGLRGGETPQSIDINI-EDDI TG-----HVTAGDHVRVTGILKLDQ---RGNDN----EKSP-MFDIYMEGVSVEIED--E QFEDMEITDADKKEIVELSNEADIYDKMVGAIAPSIYG--YEKEKLAMMLQLFSGV-TKE LPDG-SRIRGDLHMLLIGDPGTGKCVHGDTRVTLADGHERPIREVVESNLDDPKPVDDGV WDTVDFDVPSLQSDGTVATQNAT-------KVWKRKAPETLYRIRTATGRELDVTPSHPL -------FVQS-NGRFQARKAEELESGTHVAVPRKVSTNAR--NELDVTFRQSQAHNRID LDLPPQWTPELARLIGYI-------------VAEGYVEQRPDN---T------------- ---------------GYVSITNNDREVLDDAKSVLETLNLNVTERSSHEGKTTRELLCSA GEFVSFLASLDETLLQSSAERRVPQDIMRASDNVVTGFIRGYIEGEGHVSTSQREIT--- VASMSKPLLEDVRTLLVTQGITAQLQ-------------PRNNGSYRLRISGNSFHDYAE KIGFITERKTEACQQFQGTRG--NTNLD-----------IVPNLGPELRRIREALGLTQS ECGLPRSTYQHYERGRRNPSRDSFESVLDAFQARLAEMNNDTPISDTARSDGGGTGS--- -------------------------------------------------LRQDLDSLTAF VEGDMAWDRIESIEPIEHDEKWVYDLEIEGTHNYLTNG-VVSHNSQMLSYIEN-IAPRSV YTSGKGSSSAGLTAAAVRD-DFGDGQQWTLEAGALVLADQGIAAIDELDKMSPEDRSAMH EALEQQRISVSKAGINATLKSRCSLLGAANPKYGRFDQY-EPIGEQID---LEPALISRF DLIFTVTDKPDEEKDRNLAEHIIQTN---YAGELH-T----------------------H RTENPTSNFSE--------EEVGTVTEEVAPTIEPDLLRKYVAYAKRNCFPT-MTEEAKS RIEDFYVDLRMK-----G----QDEDAP--VPVTARKLEALVRLAEASARIRLSDTVDEA DADRAVDIAHYCLKEI-GVDPETG-EFDADVVETGQS---KTQRDRIQNIKGIIS-DIED ----EYD---E-GAPADVVIERAEEV-GI-DES--KAEHEIDKLK-QKGEVYEPRT-DHL RTT------- ;MULTISPECIES: helix-turn-helix domain-containing protein [Haloarcula] 10Haloarcula_WP_014039080.1 -------------------------------------MATAENTELIDRFEEFY--RN-- -Y-------YRNEIGELAQKYPND---QKS-LYIDW-DDLYRF-D--P---D--LADDYR -----TKPEQIQEYAEEALRLYDLP------------VDVSLGQ--------AHVRVR-- --NL--P--E---SEDIRDLR--HEHHGNLVAVRGIIRKATDVRPKVIEAAFE--CQR-- CGT---LTRI---P------QTAG--DFQE-P-HDCQ--------GC--ERQ--G-P--- -----------FRLNT------DQSQFIDAQKLRVQESPEGLRGGETPQSIDINI-EDDI TG-----HVTAGDHVRVTGILKLDQ---RGNDN----EKSP-MFDIYMEGVSVEIED--E QFEDMEITDADKKEIVELSNEADIYDKMVGAIAPSIYG--YEKEKLAMMLQLFSGV-TKE LPDG-SRIRGDLHMLLIGDPGTGKCVHGDTRVTLADGHERPIREVVESNLDDPKPVDDGV WDTVDFDVPSLQSDGTVATQNAT-------KVWKRKAPETLYRIRTATGRELDVTPSHPL -------FVQS-NGRFQARKAEELESGTHVAVPRKVSTNAR--NELDVTFRQSQAHNRID LDLPPQWTPELARLIGYI-------------VAEGYVEQRPDN---T------------- ---------------GYVSITNNDREVLDDAKSVLETLNLNVTERSSHEGKTTRELLCSA GEFVSFLASLDETLLQSSAERRVPQDIMRASDNVVTGFIRGYIEGEGHVSTSQREIT--- VASMSKPLLEDVRTLLVTQGITAQLQ-------------PRNNGSYRLRISGNSFHDYAE QIGFITARKTEACRQFEGTHG--NTNLD-----------IVPNLGPELRRIREALGLTQS ECGLPRSTYQHYERGRRNPSRDSLESVLDAFQARLAEMNNDTPISDTARSDGGGTGS--- -------------------------------------------------LRQDLDSLTAF VEGDMAWDRIESIEPIEHDEKWVYDLEIEGTHNYLTNG-VVSHNSQMLSYIEN-IAPRSV YTSGKGSSSAGLTAAAVRD-DFGDGQQWTLEAGALVLADQGIAAIDELDKMSPEDRSAMH EALEQQRISVSKAGINATLKSRCSLLGAANPKYGRFDQY-EPIGEQID---LEPALISRF DLIFTVTDKPDEEKDRNLAEHIIQTN---YAGELH-T----------------------H RTENPTSNFSE--------EEVGTVTEEVAPTIEPDLLRKYVAYAKRNCFPT-MTEEAKS RIEDFYVDLRMK-----G----QDEDAP--VPVTARKLEALVRLAEASARIRLSDTVDEA DADRAVDIAHYCLKEI-GVDPETG-EFDADVVETGQS---KTQRDRIQNIKGIIS-DIED ----EYD---E-GAPADVVIERAEEV-GI-DES--KAEHEIDKLK-QKGEVYEPRT-DHL RTT------- ;helix-turn-helix domain-containing protein [Haloarcula hispanica] 11Haloarcula_hispanica_WP_146417699.1 -------------------------------------MATAENTELIDRFEEFY--RN-- -Y-------YRNEIGELAQKYPND---QKS-LYIDW-DDLYRF-D--P---D--LADDYR -----TKPEQIQEYAEEALRLYDLP------------VDVSLGQ--------AHVRVR-- --NL--P--E---SEDIRDLR--HEHHGNLVAVRGIIRKATDVRPKVIEAAFE--CQR-- CGT---LTRI---P------QTAG--DFQE-P-HDCQ--------GC--ERQ--G-P--- -----------FRLNT------DQSQFIDAQKLRVQESPEGLRGGETPQSIDINI-EDDI TG-----HVTAGDHVRVTGILKLDQ---RGNDN----EKSP-MFDIYMEGVSVEIED--E QFEDMEITDADKKEIVELSNEADIYDKMVGAIAPSIYG--YEKEKLAMMLQLFSGV-TKE LPDG-SRIRGDLHMLLIGDPGTGKCVHGDTRVTLADGHERPIREVVESNLDDPKPVDDGV WDTVDFDVPSLQSDGTVATQNAT-------KVWKRKAPETLYRIRTATGRELDVTPSHPL -------FVQS-NGRFQARKAEELESGTHVAVPRKVSTNAR--NELDVTFRQSQAHNRID LDLPPQWTPELARLIGYI-------------VAEGYVEQRPDN---T------------- ---------------GYVSITNNDREVLDDAKSVLETLNLNVTERSSHEGKTTRELLCSA GEFVSFLASLDETLLQSSAERRVPQDIMRASDNVVTGFIRGYIEGEGHVSTSQREIT--- VASMSKPLLEDVRTLLVTQGITAQLQ-------------PRNNGSYRLRISGNSFHDYAE QIGFITARKTEACRQFEGTHG--NTNLD-----------IVPNLGPELRRIREALGLTQS ECGLPRSTYQHYERGRRNPSRDSLESVLDAFQARLAEMNNDTPISDTARSDGGGTGS--- -------------------------------------------------LRQDLDSLTAF VEGDMAWERIESIEPIEHDEKWVYDLEIEGTHNYLTNG-VVSHNSQMLSYIEN-IAPRSV YTSGKGSSSAGLTAAAVRD-DFGDGQQWTLEAGALVLADQGIAAIDELDKMSPEDRSAMH EALEQQRISVSKAGINATLKSRCSLLGAANPKYGRFDQY-EPIGEQID---LEPALISRF DLIFTVTDKPDEEKDRNLAEHIIQTN---YAGELH-T----------------------H RTENPTSNFSE--------EEVGTVTEEVAPTIEPDLLRKYVAYAKRNCFPT-MTEEAKS RIEDFYVDLRMK-----G----QDEDAP--VPVTARKLEALVRLAEASARIRLSDTVDEA DADRAVDIAHYCLKEI-GVDPETG-EFDADVVETGQS---KTQRDRIQNIKGIIS-DIED ----EYD---E-GAPADVVIERAEEV-GI-DES--KAEHEIDKLK-QKGEVYEPRT-DHL RTT------- ;hypothetical protein EU551_03420 [Candidatus Lokiarchaeota archaeon] 12Candidatus_Lokiarchaeota_archaeon_TFF85739.1 ---------------------------------------MEDSAEIVRKFESFF--SE-F VDDDGQHK-YENLIAQMGPNE------IIS-LEIDY-DDLLRF-D--P---D--LARALL -----NEPEFYINLASMAIKHRLRI------MDEEYANRNEY----------FHARIK-- --NL-----ESTNKINLRKIR--ASHIGKLIQVTGILTRANKVSPLMTRGVFK--CLS-- CND--AIIPV-DQE--------DN--EFTR-P-LTCP--------QC--NRK--G-P--- -----------FKLLL------DRSTYIDWQKIRVQEKPEELPPGQLPRFIDGYL-LEDI VD-----TARPGERVTLAGILKAKQ---ISTQQ----GKLT-IFRTYVDINHIEKQE--V EIESLEVTDEEEEEILDLAADPWIYRKLIRSIAPSIYG--LDEIKEALLLLLFGGV-SRQ RRDG-TIRRGQIHVLLVGDPGVGKSIHYDEEIYLYNNENFIKDKAKSKIGIFIDELLNNY SDEVHYYGDTEVLNLEGIEDYYTQSFNFDSLRSEISKITEISRHKSSEIFEIELKSGAKF KATGNHAFTTIEDGDFILKSVDQLEKGDYLPISRKINSFKEIDKIKIRDYVNHNLIIDVD QLTNNDFNQDINNKILKTKFIKPSKGNMFNPISSKLVLNESLGRIFG------------- ---------------LFLAEGSFERNGIRITNLDKDIRLQLKQDFIDNFGKYTEYKRSID FYSIIVKKLFKKLFNSNAYNKQIPQFFYNAPKPFIKGLLTGYFSGDGTIGNTGYIS---- VISASGLFIKDLRNLLGIFGIQGVLRKKIVRSGK-----YRGNIYHKLLLYGQEIFKFEK EINFIDNKRRKKLQFLINKMKRRARYQS---------LDMIPNFGRKFNDAINDLNISQA RNSPHRNFCAELRGKTYRQRVGRLYLKKVVNRFDNFKNKYV------------------- -------------------------------------------------KSEKLDFLKKL AYSDIFWDKIISISKIQNDHAYVYDIGTLNNHFILVNGHIIAHNSQLLKSGSK-IAPRGI YTSGKGSTAAGLTAAVLRD-KDT-GN-LSLEAGVLVLADNGIAAIDEFDKMRSEDRIAIH EAMEQLSISIAKAGIIATLNARTSIIAAANPYHGRYDDY-KTVAENIK--KLPPTILSRF DLIFILKDRPDPTGDERMADFILRAE----EEEPP------------------------- -----------------------------EPPIDYDTLKNYIYYAKKHCHPR-ITRDAVE EIKSFYLQTRSA-----G----AEPDTP--VPITARYLEGLIRLAEARAKMALHEEVTVE DAQAVIQLMNFSLSQV-GIDQETG-ISDIDAIETGIT---TTHRRRLEQINQLIR-QLIQ ----EKG---GEPVTLDEIKEAASRL-RI-SPQ--QVEEEINTLR-TRGVLYEPRS-GTY GIVED----- ;helix-turn-helix domain-containing protein [Haloarcula sp. K1] 13Haloarcula_sp._K1_WP_064288519.1 -------------------------------------MATAENTELIDRFEEFY--RN-- -Y-------YRNEIGELAQKYPND---QKS-LYIDW-DDLYRF-D--P---D--LADDYR -----TKPEQIQEYAEEALRLYDLP------------VDVSLGQ--------AHVRVR-- --NL--P--E---SEDIRDLR--HEHHGNLVAVRGIIRKATDVRPKVIEAAFE--CQR-- CGT---LTRI---P------QTAG--DFQE-P-HDCQ--------GC--ERQ--G-P--- -----------FRLNT------DQSQFIDAQKLRVQESPEGLRGGETPQSIDINI-EDDI TG-----HVTAGDHVRVTGILKLDQ---RGNDN----EKSP-MFDIYMEGVSVEIED--E QFEDMEITDADKKEIVELSNEADIYDKMVGAIAPSIYG--YEKEKLAMMLQLFSGV-TKE LPDG-SRIRGDLHMLLIGDPGTGKCVHGDTRVTLADGRERPIREVVESNLDDPRPVDDGV WDTVDFDVPSLQSDGTVATQNAT-------KVWKREAPETLYRIRTATGRELDVTPSHPL -------FVQS-DGRFQARKAEELESGTHVAVPRKVSTNAC--NELDVTFRQSQAHNRID LDLPPQWTPELARLIGYI-------------VAEGYVEQRPDN---T------------- ---------------GYVSITNNDREVLDDAKSVLETLNLNVTERSSHEGKTTRELLCSA GEFVSFLASLDETLLQSSAERRVPQDIMRASDNVVTGFIRGYIEGEGHVSTSQREIT--- VASMSKPLLEDVRTLLVTQGITAQLQ-------------PRNNGSYRLRISGNSFHDYAE KIGFITERKTEACQQFQGTRG--NTNLD-----------IVPNLGPELRRIREALGLTQS ECGLPRSTYQHYERGRRNPSRDSFESVLDAFQARLAEMNNDTPISDTARSDGGGTGS--- -------------------------------------------------LRQDLDSLTAF VEGDMAWDRIESIEPIEHDEKWVYDLEIEGTHNYLTNG-VVSHNSQMLSYIEN-IAPRSV YTSGKGSSSAGLTAAAVRD-DFGDGQQWTLEAGALVLADQGIAAIDELDKMSPEDRSAMH EALEQQRISVSKAGINATLKSRCSLLGAANPKYGRFDQY-EPIGEQID---LEPALISRF DLIFTVTDKPDEEKDRNLAEHIIQTN---YAGELH-T----------------------H RTENPTSNFSE--------EEVGTVTEEVAPTIEPDLLRKYVAYAKRNCFPT-MTEEAKS RIEDFYVDLRMK-----G----QDEDAP--VPVTARKLEALVRLAEASARIRLSDTVDEA DADRAVDIAHYCLKEI-GVDPETG-EFDADVVETGQS---KTQRDRIQNIKGIIS-DIED ----EYD---E-GAPADVVIERAEEV-GI-DES--KAEHEIDKLK-QKGEVYEPRT-DHL RTT------- ;helix-turn-helix domain-containing protein [Haloarcula salaria] 14Haloarcula_salaria_WP_127013916.1 -------------------------------------MATAENTELIDRFEEFY--RN-- -Y-------YRNEIGELAQKYPND---QKS-LYIDW-DDLYRF-D--P---D--LADDYR -----TKPEQIQEYAEEALRLYDLP------------VDVSLGQ--------AHVRVR-- --NL--P--E---SEDIRDLR--HEHHGNLVAVRGIIRKATDVRPKVIEAAFE--CQR-- CGT---LTRI---P------QTAG--DFQE-P-HDCQ--------GC--ERQ--G-P--- -----------FRLNT------DQSQFIDAQKLRVQESPEGLRGGETPQSIDINI-EDDI TG-----HVTAGDHVRVTGILKLDQ---RGNDN----EKSP-MFDIYMEGVSVEIED--E QFEDMEITDADKTEIVELSSEPDIYDKMVGAIAPSIYG--YEKEKLAMMLQLFSGV-TKE LPDG-SRIRGDLHMLLIGDPGTGKCVHGDTRVTLADGHERPIREVVESNLDDPKPVDDGV WDTVDFDVPSLQSDGTVATQNAT-------KVWKREAPETLYRIRTATGRELDVTPSHPL -------FVQS-DGRFQARKAEELESGTHVAVPRKVSTNAC--NELDVTFRQSQAHNRID PDLPPQWTPELARLIGYI-------------VAEGYVEQRPDN---T------------- ---------------GYVSITNNDREVLDDAKSVLETLNLNVTERSSHEGKTARELLCSA GEFVSFLASLDETLLQSSTERRVPQDIMRASDNVVTGFIRGYIEGEGHVSTSQREIT--- VASMSKPLLEDVRTLLVTQGITAQLQ-------------PRNNGSYRLRISGQSFHDYAE QIGFITARKTEACRQSEGTHG--NTNLD-----------IVPNLGPELRRIREALGLTQS ECGLPRSTYQHYERGRRNPSCDSLESVLDAFETRLAEMNNDTPISDTARSDGGGTGS--- -------------------------------------------------LRQDLNGLAAL VEGDIAWDRIESIEPIEHDEKWVYDLEIEGTHNYLTNG-VVSHNSQMLSYIEN-IAPRSV YTSGKGSSSAGLTAAAVRD-DFGDGQQWTLEAGALVLADQGIAAIDELDKMSPEDRSAMH EALEQQRISVSKAGINATLKSRCSLLGAANPKYGRFDQY-EPIGEQID---LEPALISRF DLIFTVTDKPDEEKDRNLAEHIIQTN---YAGELH-T----------------------H RTENPTSNFSE--------EEVGTVTEEVAPTIEPDLLRKYVAYAKRNCFPT-MTEEAKS RIEDFYVDLRLK-----G----QDEDAP--VPVTARKLEALVRLAEASARIRLSDTVDEA DADRAVDIAHYCLKEI-GVDPETG-EFDADVVETGQS---KTQRDRIQNIKGIIS-DIED ----EYD---E-GAPADVVIERAEEV-GI-DES--KAEHEIDKLK-QKGEVYEPRT-DHL RTT------- ;helix-turn-helix domain-containing protein [Haloarcula sp. CBA1127] 15Haloarcula_sp._CBA1127_WP_058993489.1 -------------------------------------MATAENTELIDRFEEFY--RN-- -Y-------YRNEIGELAQKYPND---QKS-LYIDW-DDLYRF-D--P---D--LADDYR -----TKPGQIQEYAEEALRLYDLP------------VDVSLGQ--------AHVRVR-- --NL--P--E---SEDIRDLR--HEHHGNLVAVRGIIRKATDVRPKVIEAAFE--CQR-- CGT---LTRI---P------QTAG--DFQE-P-HDCQ--------GC--ERQ--G-P--- -----------FRLNT------DQSQFIDAQKLRVQESPEGLRGGETPQSIDINI-EDDI TG-----HVTAGDHVRVTGILKLDQ---RGNDN----EKSP-MFDIYMEGVSVEIED--E QFEDMEITDADKKEIVELSNESDIYDKMVGAIAPSIYG--YEKEKLAMMLQLFSGV-TKE LPDG-SRIRGDLHMLLIGDPGTGKCVHGDTRVTLADGHERPIREIVESNLDDPNPVDDGV WDAVDFDVPSLRQDGTIATQRAT-------KVWKREAPDTLYRIRTSTGRELDITPSHPL -------FVQA-DGRFQARKAEELESGTHIAVPRELSTDGY--DDLDITFRESQANNSVD LELPAQWNPELARLIGYI-------------VAEGYVEQRADN---T------------- ---------------GFVSITNNDVELLDDAKSALETLNLNVTERDPHDGKTARELLCSA GEFVSFLAALDETLLASSADRRVPQDIMRASDDVVSGFIRGYIEGEGHVSTSQREIT--- VASMSKQLLKDVRSLLVTQGITAQLQ-------------PRSNGSYRLRISGNSFHDYAE KIGFVTERKTEACQQFEGVRG--NTNLD-----------IVPALGPELRRLREALGLTQD ECGLPRSTYQHYERGRRNPSHDSLESVLDAFETRLAAMDRNSPAGDTAASDGGGTDS--- -------------------------------------------------LRRDLDALTAL VEGDIAWDRIESIEPIEHDEKWVYDLEIEGTHNYLTNG-VVSHNSQMLSYIEN-IAPRSV YTSGKGSSSAGLTAAAVRD-DFGDGQQWTLEAGALVLADQGIAAIDELDKMSPEDRSAMH EALEQQRISVSKAGINATLKSRCSLLGAANPKYGRFDQY-EPIGEQID---LEPALISRF DLIFTVTDKPDEEKDRNLAEHIIQTN---YAGELH-T----------------------H RTENPTSNFSE--------EEVGTVTEEVAPTIEPDLLRKYVAYAKRNCFPT-MTEEAKS RIEDFYVDLRMK-----G----QDEDAP--VPVTARKLEALVRLAEASARIRLSDTVDEA DADRAVDIAHYCLKEI-GVDPETG-EFDADVVETGQS---KTQRDRIQNIKGIIS-DIED ----EYD---E-GAPADVVIERAEEV-GI-DES--KAEHEIDKLK-QKGEVYEPRT-DHL RTT------- ;helix-turn-helix domain-containing protein [Halomicroarcula sp. LR21] 16Halomicroarcula_sp._LR21_WP_135303433.1 -------------------------------------MATAENTELIDRFEEFY--RN-- -Y-------YRNEIGELAQKYPND---QKS-LYVDW-QDLYRF-D--P---D--LADDYR -----TKPEQLQEYAEEALRLYDLP------------VDVSLGQ--------AHVRVQ-- --NL--P--E---SEDIREIR--HEHHGNLIAVQGIVRKATDVRPKVLTAAFE--CQR-- CGT---LTRI---P------QAAG--DFQE-P-HECQ--------GC--ERQ--G-P--- -----------FRLNT------DQSEFIDAQKLRVQESPEGLRGGETPQSIDINV-EDDI TG-----QVTAGDHVRVTGILKLDQ---RGNDR----EKSP-MFDIYMDGVSVEIED--E QFEDMEITDADKKEIVELSNESGIYEKMVGAIAPSIYG--YEKEKLAMMLQLFSGV-TKE LPDG-SRIRGDLHMLLIGDPGTGKCVHGDTRITLADGRNVTIRKLVESNLDDPKPVDDGM WDSVDFEVPSLQDDGTIATQQAT-------KVWKREAPDTLYRIRTARGREIDVTPSHPL -------FVQS-DGRFQATKAENLSEGAHIATPRDVPTSGR--DNLDIEFRKSKAHNRID LELPDEWTPDLGRLLGYL-------------TAEGYVEKRADN---T------------- ---------------GFVSITNNDRAVLDDAKAVLESLNLNVTERVPHDGKDARELFCSA GEFVSFLALLDETLLSSSSERRVPTDIMSASDAVVAGFLKGYIEGEGHVSTSQREIT--- VASMSRGLLEDVRSMLLSLGITSQLK-------------PRNNGSYRLRISGDSFGRYVE RVGFVTSRKREACEQYDGTNA--NTNLD-----------VIPAVGTELRRLRETLGLTQS ECGIPRSTYQHYERGRRNPGRENLAVVVEAFRARLNEIDAPPEGAPATTDGGGLDA---- -------------------------------------------------VRRDIDALGAL AEGDVSWDRIESIEPVEPDEEWVYDLEVEGTHNYVSNG-VVSHNSQMLSYIRE-IAPRSV YTSGKGSSSAGLTAAAVRD-DFGDGQQWTLEAGALVLADQGIAAVDELDKMSPEDRSAMH EALEQQRISVSKAGINATLKSRCSLLGAANPKYGRFDQY-EPIGEQID---LEPALISRF DLIFTVTDQPNEEEDRNLAQHIIQTN---YAGELN-T----------------------H RVQNATSNFSE--------EEVDTVTDEVAPTIDPDLLRKYIAYAKRNCFPT-MTEEAKS VIEDFYVDLRLK-----G----QDDDAP--VPVTARKLEALVRLAEASARIRLADTVEEE DADRAVDIAHYCLKEI-GVDPETG-EFDADVVETGTS---KSQRDRIQNIRGIIA-DIED ----EYD---E-GAPIDVVVERAEEV-GI-DES--KAEHEIEKLK-QKGEVYEPRT-DHL RTT------- ;helix-turn-helix domain-containing protein [Halobacterium jilantaiense] 17Halobacterium_jilantaiense_WP_089669321.1 -------------------------------------MAQAANQELVDRFEEFY--RR-- -Y-------YSDDVAELAREYPRE---SKS-LELDW-RDLYQM-D--P---D--LADDYI -----NHPDQLQEAAEEALRLYDLP------------VDVSLGQ--------AHVRVQ-- --GL--T--E---HTEIRAIR--AEHLNTLVSVQGMVRKATDVMPKIERAVFV--CQR-- CGA---ETEV---P------QGDA--GFQE-P-YQCE--------SC--ERQ--G-P--- -----------FKLDP------DRSEFVDSQKLRVQESPEGLAGGETPQAIDIHI-EDDA TG-----EVTPGDHVTVTGVLRLDQ----SEDS----TDSP-VFDHYMEGSSVVVED--A EFEEMNITEEDKQEIIELSDHEDIYEEMVDSMAPAIYG--HRQAKLAMMLQLFSGV-TKH LPDE-SRIRGDLHMLLIGDPGTGKCVRGDTTVTLADGSEHEIRELVESNLDDPKPVDDGV WDDADIAVPSLAPDGTLVQRRAT-------KVWKREAPETMYRVRTANGHEVTVTPSHPL -------FVPG-LQGPEAVRAEDLDSGQFVATPRQLETNGD--DTLDVSYRESRSYNAVH IDLPDEWSPTLARLIGYV-------------VAEGYVEQRDDN---T------------- ---------------GYVSVTNNDEAVLDEVKGALDAIGANHHQREPHEGKSAREVICGS GEFVSFLAELDAGLLDGSAKKRVPNAVKRASDGTKRAFLAAFVEGEGHVSATEREIS--- VASTSRELLDDVRSLLLSLGITSQLH-------------PRENGSYRLRISGGMFKRYVT EVGFVTDRKSDAAAAFEETDG--NTNTD-----------VVPVGGDELRSLRNELGLTQA DCGIPRSTYQHYERGSRNPSRESLSAVATAFSNAVDETVAADGGTD-------------- -------------------------------------------------VTARVGAVEAA ATDDIAWDRIDTIEEVETDEDWVYDLEVEGTHSYLTDG-VVSHNSQMISYVQN-IAPRSV YTSGKGSSAAGLTAAAVRD-DFGDGQQWTLEAGALVLADNGVAAVDELDKMADDDRSAMH EALEQQKISISKAGINATLKARCSLLGAANPKYGRFDQY-EPIGEQID---LEPALISRF DLIFTVTDSPDPEEDAALAEHILQTN---YAGELN-T----------------------Q NEQLANANYTE--------EEIDSQTEEVAPAIEPELLRKYIAYARRTCFPT-MTAEAKQ AIEDFYVDLRSK-----G----ADEDAP--VPVTARQLEAIVRLAEASARLRLSDTVEQE DADRVIAIVQSCLQDI-GVDPETG-EFDADVVETGQS---KTQRDRVKNVKALIG-EIED ----EFD---E-GAPVEEVLDRAEEI-GM-DAG--KAEHEIEKLK-EKGELYQPNK-DHL RSI------- ;hypothetical protein DRO01_00630 [Candidatus Korarchaeota archaeon] 18Candidatus_Korarchaeota_archaeon_RLG42890.1 -----------------------------------MGETAEFDGDLVAVYEDFI--VT-F VDEAGERK-YLNKIPEMVESR------KRS-LRVDY-QDLFSH-L--P---SREIAKDLL -----VNPQRHLEAASLALARVVRRYGDISGEELELYASGK-----------FHVRFY-- --NL--P--T---TASIRDLP--SYSLGRFVQLSGIVIRVSDVFDKPVKIAYV--CRNPD CPDYGVPLLL---D------------PMEPKP-KTCP--------TC--GKA--T----- -----------LKRDL------EKTELVSWQVIRVQERPEDLPPGAMPKHVDAIL-TDDL VD-----EVKPGDRVTLTAIINLRPARRQEDSG-----YGI-LFKRYLVVNDVEVPT--R TYEKIEITPEDERAILELARDPKLEEKIVDSIAPSIYG--HRIKKKAIALALFGGN-PVV LPDG-TRIRGEINLLFVGDPGTAKCVSRDTLVFTKDGPTRVDSLIDESTAFDAPDGKVSR VSTRVLSMSPTLSLDWVDPTAAA----------KRSQNSDLLEVRTKTGLRIKVTKNHPF -------LVLDTDGYVKYLPASELRPGTFVAIVGNFQPPNVQPPITHRVQITPSLMELLG ILLTRARILDAGRGREYH------------------------------------------ -----------------------LLLPPRAAQRFAELAQEVGVVRLEEHGRLCHVRLRVK KRLAADLSRLIPTLDGHPSTREIPFWIVSAEIPHLVAFLKGYLRAESSYLKKTRCLA--- IVARNPKILHQLRLILSRLGVTHPRI-------------QPSKSGHRLLLSASQISILNQ NVDLSEILPSEALIRRDASDSDLGD--------------KIPHVGKILHRIRRSLGVSRE RLRIPISTLIRYERGLAHIPRSRLRKVLLELERAAGDLLRSYPTGRE------------- -------------------------------------------------IRRELAYLNML VESDVAWDEVESVRTVHGD-GWVYDVEVPYNRNFVANG-FIVHNSQLLKYTAQ-IAPRGL YTTGKGATAAGLTAAVVRD-AAT-GG-WTLEAGALVLADRGVACIDEFDKMNENDRRAIH EAMEQQTISIAKAGIVATLNARTTIIAAANPKYGRYDPL-RSPAENIN---LPPTILSRF DLIYLIKDVPEEDYDAGVADHILKAR----MGVNP------------------------- ---------------------------NVEPAIPPDLLKKYIAYARQRIRPQ-MTEEASK VIREFYLSMRRE-VGRLAGE--MEGPLP--IPLTARQLEALIRLAEARARMFLRSYVTEE DALTAVELMREMLYDV-GLDRTTG-MPDMTG-VVGAY---MSATRRREELMKLLN-EMAT ----KADS--R-MVSEEEFIRAAMEVLQI-EER--IVRNEIRVLR-ENGLIYSPRP-GFL KPASRSTEF- ;helix-turn-helix domain-containing protein [Haloterrigena daqingensis] 19Haloterrigena_daqingensis_WP_076583773.1 -------------------------------------MAQAGNSELVDAFEQFF--RN-- -Y-------YDNQIKQLAQRYP---NEQRS-LHVDW-QDLYRY-D--P---D--LADDFL -----NQPEQLQRYAEEALRLYDLP------------IDVSLGQ--------AHVRVK-- --NL--P--D-TETPEIRDIR--ARDMNSLVQVHGIVRKATDVRPKIEEAAFE--CQL-- CGT---LSRI---P--Q---S-SG--DFQE-P-HECQ----G----C--ERQ--G-P--- -----------FRVNF------DQSEFIDSQKLRMQESPEGLRGGETPQSLDVHI-EDDI TG-----EVTPGDHVSATGVLRLEQ---QGNEQ----EKSP-VFDFYMEGMSVDIDE--E QFEDMDITDEDKEEIVRLSSSEGIYEKMIASIAPSIYG--YDQEKLAMILQLFSGV-TKQ LPDG-SRIRGDLHMLLIGDPGTGKCVRGDTKVALADGRNVSIREIVESNLEDPKPIDDGW YDEIDLEVPSLQSDGSIAPQRAT-------KVWKREAPEQMYRIQTSSGRELEVTPSHPL -------FVQR-DGQFEPVVASDLTEGQFIATPRALPTEGE--NVLDVDFRQSQSRNAVQ LDLPTEWTPSLARLIGYI-------------IAEGYVEQRDDN---T------------- ---------------GFVSITNNDREVLDDAANALEELGLNTTERSPCESKEARELRCSA GEFVSFLETLEPCILQSSKKQRVPDAIFTASESAKSGFLTAFIEGESHVSESQREIT--- VASMSRELLENVRTLLLSVGIRSQLY-------------ERRNDSYRLRISGNEFSKYVS QIGFVTQRKRETVSQHANTAR--NTNLD-----------IVPNLGSELRQIRESLSLTQA DCRLPRSTYQNYERGSKNPSRESLRKVISAFKDALPAKADQSEADNVVADGGS------- -------------------------------------------------IETSIAALEPF AEGDVCWECIESIDRIEPDYDWVYDLEVEETHNYVSNG-VISHNSQMLGYIQN-IAPRAV YTSGKGSSSAGLTAAAVRD-DFGDGQQWTLEAGALVLADQGIAAVDELDKMRSEDRSAMH EALEQQKISVSKAGINATLKSRCSLLGAANPKYGRFDHY-EPISEQID---LEPALISRF DLIFTVTDQPDEEKDRNLAEHIITTN---YAGELT-T----------------------Q REQMTSMDVSS--------EEIEEMTEQVDPEIDSELLRKYIAYSKQNCHPR-MTEAARE AIRDFYVDLRSQ-----G----TDEDAA--VPVTARKLEALVRLSEASARVRLSDTVEET DATRVIEIVRSCLQDI-GVDPETG-EFDADIVEAGTS---KSQRDRIKNLKQLIS-DIEE ----EYD---D-GAPVDIVLERAEEV-GM-DHS--KAEHEIEKLK-QKGEVYEPST-NTL RTT------- ;helix-turn-helix domain-containing protein [Halobacterium sp. DL1] 20Halobacterium_sp._DL1_WP_009487222.1 -------------------------------------MAQAANQELVDRFEEFY--RR-- -Y-------YSDDVAELAREYPRE---SKS-LELDW-RDLYQM-D--P---D--LADDYI -----NHPDQLEEAAEEALRLYDLP------------VDVSLGQ--------AHVRVF-- --GL--E--E---STEIRDIR--AEHLNTLIGVQGMVRKATDVMPKIQRAVFV--CQR-- CGA---ETEV---P--Q---S-DA--GFQE-P-YQCE--------SC--ERQ--G-P--- -----------FKLDP------ERSEFVDAQKLRIQESPEGLSGGETPQSIDIHI-EDDI TG-----EVTPGDHITATGVLRLDQ----GEES----TDSP-VFDLYMEGSSIVVED--E EFEEMDITEEDKQQIIEISERDDIYEQMVDSMAPAIYG--HREAKLAMMLQLFAGV-TKE LPDG-SRIRGDLHMLLIGDPGTGKCVRGDTTVTLADGSEHEIRDLVEANLDDPKSIDDGV WDDADLEVPSLAPDGTLVQRRAT-------KVWKREATESMYRVRTANGHELTVTPSHPL -------FVPG-TNGPEAVRAEELSEGQFVATPRRLDTNGD--DSLDVSYREAESYNAVH IDLPDEWTPWLARLVGYV-------------AAEGYVEQRDDN---T------------- ---------------GYVSVTNNDEEVLDDVKDALDELGANYVEREPHDGKSAREVICGS GELVSFLHELDAGLLDGSADKRVPNAVKRASDGTKREFLTAFVEGEGHVAASEREIT--- VASTSRELLEGVRSLLLSLDITSQLH-------------PRENGSYRLRISGEMFEKYVT DAGFVTDRKSEAAASFEETSG--NTNTD-----------VVPVDGGELRSIRNELGLTQA DCGIPRSTYQHYERGSRNPSRGSLSTVASAFSEAVDETMAADGGTN-------------- -------------------------------------------------VSSRVGAVEAA ATNDVAWDRIESIEEVDTDEEWVYDLEVEGTHNYLTDG-VVSHNSQMISYVQN-IAPRSV YTSGKGSSAAGLTAAAVRD-DFGDGQQWSLEAGALVLADQGVAAVDELDKMADDDRSAMH EALEQQKISISKAGINATLKARCSLLGAANPKYGRFDQY-EPIGEQID---LEPALISRF DLIFTVTDKPDPEEDAKLARHIIQTN---YAGELN-T----------------------Q NDNIANANHSA--------EEIDAQTENVAPAIESDLLRKYIAYARRNCYPT-MTDEAKS AIEEFYVDLRSK-----G----QDEDAP--VPVTARQLEALVRLAEASARLRLSDRVEAE DADRVISIVRSCLQDI-GVDPETG-EFDADVVETGHS---KTQRDRIKNIKGLIK-EIEQ ----DFD---E-GAPIEEVLDRAEEI-GM-DAD--MAEHEIEKLK-EKGELYQPNK-DHL RSI------- ;helix-turn-helix domain-containing protein [Natronorubrum sulfidifaciens] 21Natronorubrum_sulfidifaciens_WP_008161022.1 -------------------------------------MAQAGNSELVDSFEQFF--RN-- -Y-------YDNEIKQLAQRYP---NEQRS-LHVDW-QDLYRF-D--P---D--LADDVL -----NQPEQLQRYAEEALRLYDLP------------IDVSLGQ--------AHVRIR-- --NL--P--E-TESPEIRDIR--ARDMNSLVQVHGIVRKATDVRPKIEEAAFE--CQL-- CGT---LNRI---P--Q---S-SG--DFQE-P-HECQ----G----C--ERQ--G-P--- -----------FKVNF------DQSEFVDSQKLRMQESPEGLRGGETPQSLDVHI-EDDI TG-----EVTPGDHVSATGVLRLEQ---QGNDQ----EKSP-VFDFYMEGMSVDVDE--E QFEDMDITDEDKEEIVRLSSSEDIYEKMVASIAPSIYG--YDQEKLAMILQLFSGV-TKQ LPDG-SRIRGDLHMLLIGDPGTGKCVHGDTKITLADGRNVPIREIVESNLEDPKPIDDGW YDEIDFNIPSLQDNGSIAPQRAT-------KVWKREAPDQMYRIRTSSGRELEVTPSHPL -------FVQN-DGQLKPIIADDLTTGQFIAAPRTLTVDGD--DTLNVDFRQSRSPNAVQ LDLPSQWTPSLARLIGYI-------------IAEGYVQQRDDN---T------------- ---------------GFVSITNNDREVLDDATDALKKLGLNTTERVPHESKDASELLCSA GEFVSFLEVLEPCILQPSSEQCVPDSIFEASATIKSEFLKAFIEGEGHVSESQRELT--- VASMSRNLLEDVRTLLLSVGIRSQLH-------------QRQNSSCRLRISGNEFERYVS KVGFITQRKQQAAEQYADTMR--NTNRD-----------VIPDIGSELRRIRESLSLTQA ECGLPRSTYQHYERGSRNPSRESFEKVVSTFKDALSAEEAPRENGVLADGGS-------- -------------------------------------------------LKRSLNTLEQF AEGDVCWERIESISSVEPDYDWVYDLEVEGTHNYISNG-VISHNSQMLGYIKN-IAPRAV YTSGKGSSSAGLTAAAVRD-DFGDGQQWTLEAGALVLADRGIAAVDELDKMRSEDRSAMH EALEQQKISVSKAGINATLKSRCSLLGAANPKYGRFDHY-EPISEQID---LEPALVSRF DLIFTVTDDPDEEKDRNLAEHILTTN---YAGELT-T----------------------Q REQMTSMDVSD--------EEIEAMTGQVDPEIDAELLRKYIAYAKQNCHPR-MTEEARE AIREFYVDLRLK-----G----TDEDAP--IPVTARKLEALVRLSEASARVRLSDTVEQH DAERVIEIVRSCLQDI-GVDPETG-EFDADIVEAGTS---KSQRDRIKNIKQLIS-DIEA ----EYD---D-GAPVDIVLDRAEEI-GM-DHS--KAEHEIEKLK-QKGEVYEPSM-DNL RTT------- ;helix-turn-helix domain-containing protein [Natrinema pallidum] 22Natrinema_pallidum_WP_138655183.1 -------------------------------------MAQAGNSELVDSFEQFF--RN-- -Y-------YDNEIKQLAQQYP---NEQRS-LHVDW-QDLYRF-D--P---D--LADDFI -----NQPEQLQRYAEEALRLYDLP------------IDVSLGQ--------AHVRVR-- --NL--P--E-TESPEIREIR--ARDMNSLVQVHGIVRKATDVRPKIEEAAFE--CQL-- CGT---LTRV---P--Q---S-SG--DFQE-P-HECQ----G----C--ERQ--G-P--- -----------FRVNF------DQSEFVDSQKLRVQESPEGLRGGETPQALDINI-EDDI TG-----EVTPGDHVSATGVLRLEQ---QGDQQ----EKSP-VFDFYMEGMSVEIDE--E QFEDMDITGEDKAEIVRLSSSEDIYEKMVASIAPSIYG--YDQEKLSMILQLFSGV-TKQ LPDG-SRIRGDLHMLLIGDPGTGKCVRGDTKVTLADGRDVPIRDLVESNLDNPKPIDDGW YDEIDIDVPSLQENGEIDPQRAT-------KVWKREAPDRMYRLRTAGGRELEVTPSHPL -------FVQQ-DGRFTPIVADELNEGQFIATPRSVETNSD--DTLEVDFRRSKSRNAVQ LDLPEKWTPSLARLIGYI-------------VAEGYVEQRDDQ---T------------- ---------------GFVSITNDDREVLDDAANALADLGLNVTERDPHESKDARELLCSA GEFVSFLDTLAEQLLQSSDNQCVPDPIFRTTESIRSEFLKAFLEGEGHVSESQREIT--- AASTSRELLENVRTLLLSLGIRSQLH-------------DRQNGSYRLRISGDEFEKYVS NIGFVTQRKQRIARQYADTDG--NTNLD-----------IIPNLGTELRRIREALSLTQA ECGLPRSTYQHYERGSRNPSRDSLRRVVSAFEDALPKSEHPNEGAVLTDGGT-------- -------------------------------------------------VAKDVTALKQF TEGDICWERIESIDEVDPDYDWVYDLEVDGTHNYISNG-VVSHNSQMLAYIEN-IAPRAV YTSGKGSSSAGLTAAAVRD-DFGDGQQWSLEAGALVLADQGIAAIDELDKMRSEDRSAMH EALEQQKISVSKAGINATLKSRCSLLGAANPKYGRFDQY-EPISEQID---LEPALISRF DLIFTVTDTPDEEKDRNLAEHIITTN---YAGELT-T----------------------Q REEMNQLEVSQ--------GEIDEMTEQVDPEIDAELLRKYIAYAKQNCHPR-MTEEARN AIRDFYVDLRSK-----G----TDEDAA--VPVTARKLEALVRLSEASARVRLSDTVEQS DAERVIEIVRSCLQDV-GVDPETG-EFDADIVEAGTS---KSQRDRIKNLKQLIS-DIEE ----EYD---D-GAPVDIVMERADEI-GM-DQS--KAEHEIDKLK-QKGEVYEPST-DTL RTT------- ;helix-turn-helix domain-containing protein [Haloterrigena jeotgali] 23Haloterrigena_jeotgali_WP_049965420.1 -------------------------------------MAQAGNSELVDSFEQFF--RN-- -Y-------YDSEIKQLAQQYP---NEQRS-LHVDW-QDLYRF-D--P---D--LADDFI -----NQPEQLQRYAEEALRLYDLP------------IDVSLGQ--------AHVRVR-- --NL--P--E-TESPEIREIR--ARDMNSLVQVHGIVRKATDVRPKIEEAAFE--CQL-- CGT---LTRV---P--Q---S-SG--DFQE-P-HECQ----G----C--ERQ--G-P--- -----------FRVNF------DQSEFVDSQKLRVQESPEGLRGGETPQALDINI-EDDI TG-----EVTPGDHVSATGVLRLEQ---QGDQQ----DPSP-VFDFYMEGMSVEIDE--E QFEDMDITGEDKEEIVRLSSSEDIYEKMVASIAPSIYG--YDQEKLSMILQLFSGV-TKQ LPDG-SRIRGDLHMLLIGDPGTGKCVRGDTKVTLADGRDVPIRDLVESNLDDPKPIDDGW YDEIDIDVPSLQENGEIDPQRAT-------KVWKREAPDRMYRLRTAGGRELEVTPSHPL -------FVQQ-DGRFMPIVADELNEGQFIATPRSVETNSD--DTLEVDFRRSKSRNAVQ LDLPEKWTPSLARLIGYI-------------VAEGYVEQRDDQ---T------------- ---------------GFVSITNNDREVLDDAANALADLGLNVTERDPHESKDARELLCSA GEFVSFLDTLAEQLLQSSDNQCVPDPIFRTTESIRSEFLKAFIEGEGHVSESQREIT--- AASTSRELLENVRTLLLSLGIRSQLH-------------DRQNGSYRLRISGDEFEKYVS NIGFVTQRKQRTARQYADTDG--NTNLD-----------IIPNLGTELRRIREALSLTQA ECGLPRSTYQHYERGSRNPSRDSLRQIVSAFEDALPKSEHPNTGAVLTDGGA-------- -------------------------------------------------VAKDVTALKQF AEGDICWERIESIDEVDPDYDWVYDLEVGGTHNYVSNG-IVSHNSQMLAYIEN-IAPRAV YTSGKGSSSAGLTAAAVRD-DFGDGQQWSLEAGALVLADQGIAAIDELDKMRPEDRSAMH EALEQQKISVSKAGINATLKSRCSLLGAANPKYGRFDQY-EPISEQID---LEPALISRF DLIFTVTDTPDEEKDRNLAEHIITTN---YAGELT-T----------------------Q REEMSSLEVSQ--------GEIDEMTDQVDPEIDAELLRKYIAYAKQNCHPR-MTEAARN AIRDFYVDLRSK-----G----TDEDAA--VPVTARKLEALVRLSEASARVRLSDTVEEA DAERVIEIVRSCLQDV-GVDPETG-EFDADIVEAGTS---KSQRDRIKNLKQLIG-DIEE ----EYD---D-GAPVDIVMERAEEI-GM-DQS--KAEHEIDKLK-QKGEVYEPST-NTL RTT------- ;cell division protein [Euryarchaeota archaeon CG01_land_8_20_14_3_00_38_12] 25Euryarchaeota_archaeon_CG01_land_8_20_14_3_00_38_12_PIV70301.1 --------------------------------------MDFTVETMIGIWERIL--QH-- ---------YKGDIADVERDYPE----KKS-ILVDY-NVIASE-N--S---D--FAESLL -----VQPNNTIYAGEKALKEIT---------------GFD-----------INIRIM-- --NL--P--KGVSRIGIRDLR--SEHLGKFIAAEGLVRKATEVRPKLKEAAYQ--CVR-- CGA---VIKV--SQ--------ED--MVAKEP-LECYKDQGG----C--GKSIASTR--- -----------FKLLTMISESKECSVFTDTQKLEIQESPEGLRGGAQPQRLVAYA-EDDI TG-----KISPGDRVILNGVLRSMQ---RRDRG----VKST-VFDIFLDVNSIEIEE--H EFEEISITPEDEEEIIKLSQDKGVCQKIISSIAPTIHG--MNVEKEALALQLFGGV-PKT MPDS-TKVRGDIHVLLVGDPGTAKCVSGDTEVLLADGSLKPIQSVVEGVTNKKISGIVDD GIYSETNHDILSLNSTAKNIPAK-----VNIVWKRTAPEKMYKIKTVSGKEIKVTPTHPF -------FVC--NGFITCKKAKELRKGEFIATPRKLDIFGR-AQPVNIPYTKSASNNAVR LKLPKKTTPWFWRFIGLF-------------IGEGYLEIKPYEGYIS------------- ---------------STAFFTNNDPKLLNDFYSSSKKLGLNPKMRNSHKGKIAKVIFVPS IEFGTFLVNL--GASGLSKHKYVPELLFKCSEKEIKAFLSALFDCEGTVSLKSRKIK--- ITSASKRLMKQVQHLLLRFGVHSQLHSKFGRATNSM---HKGDVYHDLYIMGEDVVTFEN EIGFSLPAKKSRLNKLTSSKKMFNTNKD-----------VIPINSMMLRKLRNDLCLSQS ECGVPRSSYQHYEKGDRKPSRSALKKIVKPFEKRYLSLKNID------------------ -------------------------------------------------ILHRFSILKTL ADSDIFWDRVEKTEKVDSD-DFVYDLQVPEHHNFIAND-IYVHNSQLLRYITQ-ISPRGI YASGKAASAAGLTAAAVRD-EFGEGR-WTLEAGALVLADKGIAAIDELDKMSTQDRSAMH EAMEQQCISVAKAGITATLHSRCALLGAANPKFGRFDTY-TPISEQID---MPPALLSRF DLIFSIEDKPETKKDTEMAEHILRLH---YAGEIG-M----------------------H RQRKENGKYSA--------EDEEIAMKCVEPEITPVVLRKYIAYSKRHVFPV-ITKEAET ALKDYYLNLRRQ-----G----EEENAP--VPITPRQLEAFVRLSEASAKMRLNNEITRE DADRAIRIMDYCMRRV-YYDYEAG-KFDVDVVATGMT---HSQRERSITILDIIK-ELSS ---KSHDG--G--VDYAEIEERAINE-KI-PDK--KVEATVEKLK-TEGRIYQRPN-GKY YPV------- ;cell division protein [Halobacteriales archaeon SW_9_67_24] 26Halobacteriales_archaeon_SW_9_67_24_PSQ66142.1 -------------------------------------MARAEDTELIDDFEEFY--RN-- -Y-------YRNEIGELARQYPNE---QRS-LFIDW-DDLYRF-D--S---D--LADDYR -----SQPGQLQEYAEEALRLYDLP------------VDVGLGR--------AHVRIR-- --GL--Q--E---TTEIREIR--ARHRGQLLSVQGTVQKATDVRPKITEAAFE--CQR-- CGT---LTRI---P--Q---T-GG--DFQE-P-HECQ--------GC--ERQ--G-P--- -----------FDINF------DQSEFVDAQKLRVQESPEGLRGGETPQDIDVHI-EDDI TG-----AVTAGDHVRVTGVLHLDQ---QESGR----EATA-MFDVFMDGVSVEIED--E QFEDMDIDEADKRAIVDLSTEEDIYEQMVGSIAPSIYG--YEQAKLAIALQLFSGV-AKH LPDG-SRIRGDMHMLLIGDPGTGKCVSGDTTVTLADGAERPIRDIVESNLDTPTAIEDGV YDEVDLSLPSMEPDGTIAEGRAT-------KVWKREAPEVMYRIRTASGKEVEVTPSHPL -------FVQS-AGRFAATKAAALNEGAFVATPRTVPTTGD--DSLDVDYRRSESNNAVR LEPPTNWTPSLARLLGYV-------------IAEGHVQLRDDH---T------------- ---------------ASVFITNNDSEIIADIAAAYDSLGVNYTVDEPCKRKPTKLIRTAS GELVSFLEDLEPAILERSAEQRVPDAILEATPGTKREFLRAYVDAEGHVSTSQRELA--- IASMSRELLGEVQSLLLSIGIQSSIE-------------PRKNGSHRIRIGGAAFERYVE TVGFVTERKANATRDFDDISP--NTNRD-----------VVPNVGDELRRVREALALPQS ECGIARSTYQHYERGDRNPSRDSLLTVVETFEERIEWLRTTKHRIETGDWAAIGAVRDEL NVSRADLAVEMGVEQTAVSYYERNDIVPDGGQTIAGKSAVLERIGTALDVTDDVAGLRSL AESDVRWERIVSIEEVTPDDEWVYDLEVADTHTYLSNG-IVSHNSKLLQYIRQ-IAPRSV YTSGKGSSSAGLTASAVQD-DFGEGQQWTLEAGALVLADQGIAAVDELDKMESGDRSAMH EALEQQTISISKAGINATLQSRCSLLGAANPKYGRFDQY-ESIGEQID---LEPALISRF DLIFTVTDDPDPDRDRELAEHILRTN---YAGELN-T----------------------Q RTEQTAADVSQ--------SEVDAVTDTVAPAIEPDLLRKYVAYAQRNCFPT-MTEEAKE AISDFYVDLRSE-----G----ADEDAP--IPVTARKLEALVRLAEASARVRLADSVELE DAERVIEVVRTQLQDI-GVDPETG-EFDADIVETGTS---KTQRDRIKNVKALIA-EIEE ----EYD---A-GAPVEEVLDRAEET-GT-ERS--KAEHELEKLR-RQGEVYEPQT-DHL RTT------- ;hypothetical protein CEE42_14800 [Candidatus Lokiarchaeota archaeon Loki_b31] 27Candidatus_Lokiarchaeota_archaeon_Loki_b31_TKJ20447.1 --------------------------------MTTPISRPSAPIHKISRFEDFY--RL-F EDKPGIYK-YQAKINDIFSKG------SNT-LIILY-EDLLAF-D--S---Q--IAELLR -----KDPETLLENATEAFRNILKF----------QGSKLTDKD--------YFVRITTK DDKS--P--L---FISLRELR--AKNIDNLVWTKGILVRSSTIRPKLIEAAFE--CMT-- CKT---QFEV-LQL--------SS--KIKW-P-NFCINP------RC--KAKSQSD---- -----------FRLVS------KNSEFIDWQSVMIQEIPEDLPPGRIPRSIQAIL-THDL VD-----IVKPGDRVKLLGTFKSVL---AQSTK----SINSTLFKTFIDVNYIDPED--K SEGFIELSKEDKKKIENLSKEPMIQKKIARSISPVIYG--REELKMATALTLFGGT-RKK RPGG-GYKRGDIHLLFVGDPGTGKSIYGTEEIYIGTDTSTCKMWTTRKIGEFVDELLDEN LFSVILKGDTEILKLLNKNSIYTYSINPYTLKTQISRINEVSRHRTNILIQIKTQSGRVI ITTPNHSFTTLIDGELKVIDVNDIYENFNNLYLPIARNLDFGDNCDWIDISVFFDEEGLV SAKTIHQQIQLYLNDGITLSRAARISNITEGTFLSYLRDLDSIPSEDWIRRKYDTTWIPR MIELNNEFGRIVGFYLAEGDTPRSSVRISNTNEEIITILENDLIDIFGRASYYDYDDSIQ IHNVSLRHWFSSFFGNHAQNKKFDRILLSAPSDFRRCLLSAYFTGDGYIENEALFIS--- ATTASRILAFSISDMLSTFGIFSTINTKTIQSGQ-----YEGNIYYEIILTGEEVIKFYE KIGFLSTEKQQRLAIAIDIASSKTRYQK---------KDIIPNFGNILQRISNDLEIIER RGSKERDFLAELRGKAQRQRAGRLYLKKIAHIFEDLYRNKNKK----------------- -------------------------------------------------YSNDLIWLKKL TESDIFWDKIEEITKINEETS-VYDIGTDDGHFIIANGNIIVHNSEILKSAIE-VSPRGL YTSGKGSSAVGLTAAVIKD-TDT-GQ-MNLEAGAIVLANGGVAAIDEFDKMETSDRSALH EAMEQQTVSIAKAGIVATLKAQTAIIAAANPRSGRYDRY-KTPTQNIH---LPPSLLSRF DLIFIVIDRPDPANDAQMAEFILKNA---MLGPD-------------------------- -------------------DDIESKTGKISP-IPRDLLKKYIEYARRTCHPV-LTEEAKE KIKEFYLNLRGQ---------YDSEDAI--VSILARNLEALVRLSEAYAKMALREKVVKN DVDEIIKLFKRYLKDT-GYDETTG-KIDMDRILVGQS---RSSISKLDKMLTRLK-EIYE ----DGNW--K-ALERNNVIQILELEEDL-DEK--WIKDALEELI-KEGTLYEPRN-NML RFTNKDD--- ;hypothetical protein COU59_02965, partial [Candidatus Pacearchaeota archaeon CG10_big_fil_rev_8_21_14_0_10_34_12] 29Candidatus_Pacearchaeota_archaeon_CG10_big_fil_rev_8_21_14_0_10_34_12_PIO07643.1 ------------------------------------------------------------ -----------KEVGE-SIKHG-----KNI-IYTDF-MKLSEF-S--S---K--LSDEII -----TSPEETLSLMELAIEESG-L-------------V-----------NNARVRLY-- --NL--S--E-AQNIKVRNIR--SKHINELIVIEGIIRQASDVRPQVVNARFE--CPS-- CGT---IISM---L--QM----EK--KFRE-P-SRC---------SC--GRK--G----- ------------GFKL------LSKEMVDTQRLVVEESPESLSGGEQPKRINVFV-KEDL VEPQMEDKTTPGSRVKVIGILKEVPV--PLSTG----GLST-RFELAIEVNNLIPLE--E TFEELNISEEDESKILELAKDPEIFGKLAKSIVPSVWG--YEEIKKSLVLQLFGGV-KKI HVDG-QKRRGDIHILLIGDPGVAKSIGPEEKILYYTKNRHGYRKIRELFNEFGKHPKNLK VLTINQSTHAPEWESVNEIIKHP--------------PEKELIKVTTSHGKSVIATKDHS -------FITLSGGKIIPIKGEQIKKGTYLPLPINYHKEIL--NELNIKEFKIAKTNSKE IPDSIKLNEDSGFFFGIF-------------LSEGYIKSEKSISISN------------- ---------------KNKKIQEKVSKFAENLNLKSAAGKTEVVINSKSLSNMLKNYCYKE DE-----KEGNKTKGNISRIKKIPDFAFFAPKEFIKGVISGLFSGDGRFVKDKSRIKGFE LITISKKLSCGTSDLLFSIGILNKIN-------------KSEYKYKNEKRICYKIYIPSQ SIKKFRKSFNFYGREFLSYPKPVYSYNN-----------LIPCGELVYEITKKLGYNSRK TGDRTFAAEMRTIKKRGEVGRLRLRKIIKKFEQKTKE----------------------- -------------------------------------------------KLPELAALKKL AYSQIIWSKVSMIEKVKKEKE-VYDLIIPKTNTFVSNG-IGVHNSVTLNFMAD-ISPKGR YVVGKSASGAGLTATVVRD-EYLRG--WSLEAGAMVLSNKGLVCIDELEKMDATERSSMH EAMEQQTITISKANVQATLRAETSVLAAANPKLGRFDPY-QSVAQQID---LPPTLINRF DVIFTLRDIPNKEKDTKIARHVLQEH----SDEG-------------------------- ----------------------------KSMVIPREIFRKYVAYSKQRIKPK-LSPEAIE EIENFYIDLRNK---PVSS---DSTIRP--IPISARQLEALIRMSEASAKVRLDNTVTRT DAKIAIDIIKYYLTEV-GYDYESK-TFDIDKI-SGMT---TSKRNKVFIVRDLIT-QLES ----RLG---K-LIPIEEIEKEAEDN--L-SKQ--EIEDAITELI-KNSIIYEPRS-GYV QKI------- ;cell division protein [Thermococcus sp. P6] 32Thermococcus_sp._P6_WP_088881792.1 ----------------------------------------MEREEMIERFARFL--RE-Y VSDDGDEV-YLNRLRDLLTLTP-----KRS-LTIDW-THLNSF-D--P---E--LAGELL -----KNPEESILAAEDAIQIILRE------PPLLREEEFK-----------VHARFY-- --NL--P--R---TLLVKELG--SEHINRFVQVEGIITRVSEVKPFVERAVFV--CRD-- CGN--EMVRL--QR------P-YE--NIVR-P-TKCD--------SC--GSR--N----- -----------IILDV------EKSGFLNFQSFRLQDRPESLKGGQMPRFVDAIL-LDDL VD-----TALPGDRVLVTGILRVIL-----EQK----DKRP-IFRKVLEVNHIEQIS--K EIEELEISPEDEQKIRELSRRKDIVDAIVDSIAPAIWG--HKTVKKGIALALFGGV-QRV LPDG-TRLRGESHVLLVGDPGVAKCVDHDTRVLLADGSLRKIGEIVEEAVERARRRGNLG KVDDGFYAPLDLELYALDARTLKVRKVRADLAWKRTAPERMYLIRTLSGREIRVTPTHPF -------FTLE-GGSFKTRKARELKVGDFIAVPGTLPVEGK-SGRYSSTPS--------- ------------------------------------------------------------ ------------------------------------------------------------ ---------------APLKGEELPPELFVAGREELREFLRGYFEERGSL---REGSI--- VVEDGVETLKGIMHLLLRFGVKSRIREIK----------TGGKTSYRLSISGEDAILFME RIGFRRLSRAEVLERLPPAPG------N-----------ELEDLIPGVEELLEKVGVKGK APGKRELKRIVERLGEK------------------------------------------- -------------------------------------------------KTPELGFLKLL AESDIFWDRVVEKEEYEPERPWVYDLQIPEHHNFIAND-VFVHNSQILRYVAN-LAPRAI YTSGKSSSAAGLTAAAVRD-EFT-GS-WVLEAGVLVLADGGFALIDEFDKMSERDRSAIH EALEQQTISISKAGITATLNARTTVIAAANPKYGRFNRH-KSLPEQLE---LPPTLLSRF DLIFLLLDEPDEKVDSSIAEHILRVR----RGES-------------------------- --------------------------EVVTPKIPYDLLKKYIAYARKNIHPV-MSREAME ELKRYYVRMRKG-FRTSGD---EEGVQP--IPITARQLEALIRLSEAHARMRLSETVERE DARAAIGIIEEMIGKI-AVD-EEG-TLDVSILEVGKS---SRKINRIERIIDIIK-KLES ----EGE---F-GAPEDEVIEAAKQA-GIGSES--EIKKLLSDLR-RDARIYEPRA-GFY RVL------- ;hypothetical protein DRN78_02115 [Candidatus Korarchaeota archaeon] 44Candidatus_Korarchaeota_archaeon_RLG43250.1 ---------------------------------MAEKGLTLSFDELVEGYREFI--QF-Y EDDSGDPK-YRKALASMIEDQ------KRS-LSIDW-NHLYNF-N--EKMRE--IAEDVI -----IHPTLHIDAASRALKDLVNE---------LLGDLIREDKFRIYSEGDFHVRFY-- --NI--P--T---KTSLRDVT--KFSIGRLVEIEGIITRVSDIYDKLEKAIYI--CSNVD CGE---VVTV--EV------I-GG--KLRP-P-ERCP--------IC--GAP-------- -----------MKFNH------ELSEFVRWRSIRIQERPEDLPPGMMPEHIDGIL-LDDL VD-----EAKPGDRVKVVGIIRIKP-ARREERR----SEGP-IYRRYLEIVHIEVPN--R IYEKLEITPEDEEDIWKLASREDLEDLIVRSIAPSIYG--WDEVKRAIAYALFGGT-SKV LADG-TKVRGEINILMVGDPGVAKCITEDSLLISNKGVVRIGQLANGHRCLPLEDGVLIR LSDVKILSLGREGAIKWYDTVAI---------AKRRYSGYVYRIETGRGFSIDVTETHPF -------LVLDRSGRLTFKSAKELSEGDYVATIGTYEADAA-EVSPYVRILSYLYGLLLP ----------------------------------------------S------------- ---------------DFVGGKFRLRLRPEAIGDITQIAHRLRNIINVQFSVSPNELEVNI RPKGKASCEILRLLGSPIPERQIPHWILYGSRDTAFFFIKGIMSHAEEIGEKLCLPA--- ---------------------------------------LPERISLEISLIAARIGLVPI LSKEGDSWRISFNKYKEGILGLETIENT-----------LVPNIKGLLINILKNLGIAPE NVNLAINSIEAPESEGHSLPRAEVVRFLNMIRCELSDGSSDR------------------ -------------------------------------------------LRDPIMNLLVA SSPYIVWDRVTSVSRMKRDL-WVYDLEVPESHNFVASG-MIIHNSQLLKYTAQ-ISPRGL YTTGKGSTAAGLTAAVVRD-SAT-GG-WTLEAGALVLADRGTACIDEFDKMNEDDRRSIH EAMEQQTISIAKAGIVATLNARTTIIAAANPKKGRYDEY-VSVVDNIN---LPPTVLSRF DLVFIMRDEPSPEKDALVADHVLSTR----MGINP------------------------- ---------------------------EAKPPIDPSLLKKYIAYARQNINPV-LTEEAAN RIKQFYVEMRKA-SVKEVSEIPEMSFET--IAITPRQLEALIRLSEARARMHLRKEVTKE DAERAIMLMKMMLEKV-GYDVATG-TIDITGLMTGAS---FPEYKRREIVLKAIK-DMAR ----ESED--N-TVDRDIVIRTLAEKLNL-VGKEFVLEKIISDLL-KEGTIYQPEP-GKL KPIG------ ;hypothetical protein DRO06_00365 [Candidatus Korarchaeota archaeon] 49Candidatus_Korarchaeota_archaeon_RLG48940.1 -------------------------------------MAELTFEDLRERYADFL--LE-F RDPGGNPK-YRAAISQMIDRG------RRS-LPVDY-SDLAAH----PSTRE--LVRELL -----SDPEEHLKAASEALTEIVRSRMVDLDLLEEISPLVAKRR--------FHVRVR-- --NL--P--T---SVSIRDIP--YVPVGQLIQLSGIVTRVSDVYDRVVVAAFT--CTNPD CGY---TFKM-TLE--------EI--AESGRP-KVCP--------SC--GRP--G----- -----------VRQNP------DESEFESWQTIRIQERPEDLPPGAMPKHVDCVL-VDDL VD-----EVKPGDRVVVTGVVQLRPARRTEVPG-----FGQ-LFKRYLVIDYVETPM--R PYERVEISEEDEEKILELSRDPELEEKIIRSIAPSIYG--ARYIKRAIAAALFGGN-RVR LPDG-TRVRGEINLLLVGDPGTAKCVLGDSVVLTRSGPSRIDSLSNPSGALEGLEVASLG DGAGIGWSRASAWAASPHRGEVI-------------------RVVTESGLELSVTPTHPF -------LSITREGDLAFVRAVDLTRGRFLAVQAAAPPGRA-RLDPDLAEVLGVILLESR VERDSGRSITLRVLVN-------------------------------------------- -------------------------------KGYVDRLRALRPDGASISSVSLRGKRARV RITLRPPKLRDRLASGPISPRSVADLLLSLDDASLEALLAGMLGAHSRLLRARGRLALYL PSAEDALLVRTLL--------------------------NRMGVRLPEVRRLKRGYQILL NRRQAEKLRRGRLKLVVDPSDLRGSSDG-----------RVPFAAPKLREVRRLLRVGLD STPVPPATLRKYESGDTPVPADTLLALVSHYRSVLEERRASLDHLSLR------------ -------------------------------------------------RASNLLAQLET LGSAVAWDRVRELSREEFS-GLVYDIEVPGSRNFVANG-FIVHNSQLLKYAAQ-LAPRGL YTTGKGSTAAGLTAAVVRD-SST-GG-WTLEAGALVLADMGVACIDEFDKMSEEDRRAIH EAMEQQTISIAKAGIVATLNARTTIIAAANPKKGRYDPL-LSVAENIN---LPPTILSRF DLIFVIRDEPKEDQDRMIADHVLGAR----MGVNP------------------------- ---------------------------DIEPPIPLDLLRKYIAYARQRVRPR-LSREAAR VIKEYYLKMRGM----SGS---GEGLGP--LALTARQLEALIRLSEARARMFLRDVVTEE DAMVAVELMDRMLRQV-SYDVSAE-ALDITG-MVGPF---MSSTKRREEIMRMLN-RMAS ----ESPD--G-MVSEDEFVAAAMEKLKV-SRE--VLQRDLDMLK-DSGLIYSPAV-GYI APAIRRRSER ;hypothetical protein C0200_03275 [Candidatus Korarchaeota archaeon] 56Candidatus_Korarchaeota_archaeon_PNV78000.1 --------------------------------MITGEPKIVDEIKLKEKYLEFL--KS-F KDESGSRK-YEELALRAIESK------KRS-IVIDY-SDLFANIDTRE------VALDLL -----ERPVTNIRAASQAVKEFLRMNAGPLSDDLIYFNKP------------FHARFS-- --NI--P--I---RVGIREIP--SYSLGKMISVEGIVTRVSDTYDKLSEAVYT--CGA-- CGY---EISM---P------I-ED--DVVPKPPASCP--------NC--GQA-------- -----------MKFNQ------ERSSFVNWQYIRVQERPEDLPPGGMPKYIDAIL-LDDI VD-----EVKPGDRIKASAIINLRKNRKSVGDA----VFGP-LFRRFLEINFIETSS--K EYERVVITPEDEREIRKLSKDPHLEEKIVKSIAPSIYG--HETIKKAIALALFGGN-EKI LKDG-TKIRGEINLLLVGDPGTAKCITGDSYVLL-EGDLKRVDELTPESSPIHDGEDLIW RKEFDVASLNNKMRICWERSSAI---------AKRRHKGEIITVRTRMGFEIKVTPTHPF -------LTIT-NGKTEYRKASDIHPGFYIAVAGRIPALNI-KNENSLPPE--------- ----------------------------------------------L------------- ---------------IGILYYSNIKISRNKIGVQIRLMNPDILGINEIIPEKAKLEYINR NGRLSLSFDHIYDCLKAPRRERDIPSWLVFDERGFPKLMKGIIAAAGRINRAKGALS--- IVFYSKKVALKIMLALISMGYRPCMSSSGGRHKITVKGDDAADLFRRIGIKVAIAKRKRN EDGIPGIGDVLMEILGQIKSREAADLRK-----------KLKKFVTSGRPVPLSIAKEVL DLAKR------------------------------------------------------- -------------------------------------------------SGISADDIEVI VSSDVVWDEVKQVSREQFD-GWVYDIEVPSNRNFVANG-LIVHNSQLLKYVSR-ISPRGL YTTGKGSTAAGLTAAVVRD-AST-GG-WTLEAGALVLADRGTACIDEFDKMSEEDRRAIH EAMEQQTISIAKAGIVATLNARTTIIAAANPKKGRYDKM-LSVAENIN---LPPTILSRF DLIYVIKDDPSEDLDRRIAKHITETR----RGYNP------------------------- ---------------------------EAEPPIPIDLLRKYIAYARQNITPV-LTKEAGE EISRFYLSMRKM-SKDKAEAVEIMEQAP--IPITPRQLEALFRLSEARAKLYLREEVTAE DARVAIELLRAMLKDV-GYDEVTG-TYDVSGFMHESF---QSSSYRRARIMELLS-RMER ----QYEN--G-EVPRAELVAQAAKELNM-VGKEVIIEKDIRSLY-EAGRIYIPRP-GYV KIVPRRE---