>Tpetrophila RKU-1
MPMSSFKRKIKAIQIKIASPEVIRSWSGGEVKKPETINYRTFKPERDGLFCERIFGPVKDYECACGKYKG
KKYEGTVCERCGVRVESREARRKRMGHIELAAPAVHIWYLESIPSVLGTLLNMSTSDLENIIYYGSRRVI
ERAFIVTDPKDTPFSQGDVIYETEYRIYRKKWDFEVEQAFVVKNPKSPVLSDIDGEVTLKTEKSITGREI
TWIIVKNITRATHTVLPGMILVVKDGQEVEKGQDLTKEMTIDPVYAPFDGHVEIDELSNTITLKPLTTSK
DQPVVFTAPYGAKILVSNGQKVKKGDQITTSTSLPSVKSSISGTVRFGSNLNIRALEDGNFEVLSTGEVY
VEQVIEERKYPVFEGALVYVNNGDQVKKGDHLADRFLFEEEYLSATEYKIFESHYPTMFDVEERTENDRP
IVVITDIDPEVSKETGLKVGDIVTENEYEAYLQIYPEKIVADAGAQAIKKLLQNLDLEALQAEIEAELKK
LPSSSSKAIKLRRRLKMVKDFLKSGNKPEWMVLEVVPVIPPDLRPMIQIEGGRFATTDLNELYRRLINRN
NRLKKLLELGAPEIILRNEKRMLQEAVDALIHNGSDSEGKRSRRAVLKDRNGRPLKSLTDLLKGKKGRFR
RNLLGKRVDYSGRAVIVVGPHLKIHQCGIPKKMAMELFKPFVLAKLLGEGSSSKTMRKVKKAIIEKEMPE
AWEVLEEVIKGSVVLLNRAPTLHRMSIQAFEPKLVEGNAIQLHPVVCPPFNADFDGDQMAVHVPLSAAAQ
AEARFLMLSRYNIISPAHGKPISLPTQDIIIGSYYLTTVSKEFDSLKEEDVKWKFSSPEEAMLAYHLGFI
KLHTPILIKVVINGEEKRIKTTLGRVIFNSILPEDLRDYNRIFDKKQINTLVYETFKRHGIDRAADLLDD
IKDIGFHYATVSGLTLSLKDLKIPPERDEILRKTWEKVRIIEENYEKGFLTEEQRKSEIIRLWMSVTEEI
TKLTSRTLAEDPFNPIYMMVNSGARGNIDQVKQLAGIRGLMIKAYDPRSREIKSKIFKGQAIHEALTFDY
PVDKNLREGVDILQFFISTYGARKGQVDTAMNTSFAGYLTRRLVDVAQSVTVAEPDCGTHEGIRAMDLIK
EGTVVEKMNEFLFGRVLAKDVLDPETKEVLKNPETGKEYTRNTMLTDDDANFLASYKKMVDVVRYEEIDI
TELSLPNMYAEIAEPVGEYEEGTELTWDVVKAAKNEGKYRIKVKVYPVVGTVYAEEEPLYDKKGERQLLV
YQEVINEIVAKMLEENGIEKVPVRPDIIVRSPLTCESEYGVCAACYGMDLSNHKIVNVGESVGIVAAQSI
GEPGTQLTMRTFHVGGVMGASDIVSGLTTVEKTFEPYAFLREEKSGGKKEIRKYYGSESILCEVDGFVKD
IATDESGRTVIYVEDYAGNIHAYKVPKRAKVRVEKGQKVLRGETLTSGAIVWWKLLELESEKGVMTAMNL
LKIIKNAYVQQGVSIHDKHFEIIFKQMLSMATIVDPGDSDYLPDQLVPLVDIKRFNREILEGNAKVEENR
KWVIGKTLAKRIIAETEEGELVELAQKGDEVTEELLKKIIEAGIKEIDVFEKDKVVTYQILPKEPIKYKR
RLLSLKKAALNYPGWLSAAAFEETAWVLTAAAIEGKVDPLIGLKENVIVGQLIPSGTGLDVFAGIQVEET
PRAAVEEELA

>TspRQ2]
MPMSSFKRKIKAIQIKIASPEVIRSWSGGEVKKPETINYRTFKPERDGLFCERIFGPVKDYECACGKYKG
KKYEGTVCERCGVRVESREARRKRMGHIELAAPAVHIWYLESIPSVLGTLLNMSTSDLENIIYYGSRRVI
ERVFIVTDPKDTPFSQGDVIYETEYRIYRKKWDFDVEQAFVVKNPKSPVLSDIDGEVTLKTEKSITGREI
TWIIVKNITRATHTVLPGMILVVKDGQEVEKGQDLTKEMTIDPVYAPFDGHVEIDELSNTITLKPLTTSK
DQPVVFTVPYGAKILVSNGQKVKKGDQITTSTSLPSVKSSISGTVRFGSNLNIRALEDGNFEVLSTGEVY
VEQVIEERKYPVFEGALVYVNNGDQVKKGDHLADRFLFEEEYLSATEYKIFESHYPTMFDVEERTENDRP
IVVITDIDPEVSKETGLKVGDIVTENEYEAYLQIYPEKIVADAGAQAIKKLLQNLDLEALQAEIEAELKK
LPSSSSKAIKLRRRLKMVKDFLKSGNKPEWMVLEVVPVIPPDLRPMIQIEGGRFATTDLNELYRRLINRN
NRLKKLLELGAPEIILRNEKRMLQEAVDALIHNGSDSEGKRSRRAVLKDRNGRPLKSLTDLLKGKKGRFR
RNLLGKRVDYSGRAVIVVGPNLKIHQCGIPKKMAMELFKPFVLAKLLGEGSSSKTMRKVKKAIIEKEMPE
AWEVLEEVIKGSVVLLNRAPTLHRMSIQAFEPKLVEGNAIQLHPVVCPPFNADFDGDQMAVHVPLSAAAQ
AEARFLMLSRYNIISPAHGKPISLPTQDIIIGSYYLTTVGKEFDSLKEEDVKWKFSSPEEAMLAYHLGFI
KLHTPILIKVVINGEEKRIKTTLGRVIFNGILPEDLRDYNRIFDKKQINALVYETFKRHGIDRAADLLDD
IKDIGFHYATVSGLTLSLKDLKIPPERDEILRKTWEKVRIIEENYEKGFLTEEQRKSEIIRLWMSVTEEI
TKLTSKTLAEDPFNPIYMMVNSGARGNIDQVKQLAGIRGLMIKAYDPRSREIKSKIFKGQAIHEALTFDY
PVDKNLREGVDILQFFISTYGARKGQVDTAMNTSFAGYLTRRLVDVAQSVTVSEPDCGTHEGIRAMDLIK
EGTVVEKMNEFLFGRVLARDVLDPETKEVLKNPETGKEYTRNTMLTDDDANFLASYKKMVDVVRYEEIDI
TELSLPNMYAEIAEPVGEYEEGTELTWDVVKAAKNEGKYRIKVKVYPVVGTVYAEEEPLYDKKGERQLLV
YQEVINEIVAKMLEENGIEKVPVRPDIIVRSPLTCESEYGVCAACYGMDLSNHKIVNVGEAVGIVAAQSI
GEPGTQLTMRTFHVGGVMGASDIVSGLTTVEKTFEPYAFLREEKSGGKKEIRKYYGSEAILCEVDGFVKD
IATDESGRTVIYIEDYAGNIHAYKVPKRAKVRVEKGQKVLRGETLTSGAIVWWKLLELESEKGVMTAMNL
LKIIKNAYVQQGVSIHDKHFEIIFKQMLSMATIVDPGDSDYLPDQLVPLVDIKRFNREILEGNAKVEENR
KWVIGKTLAKRIIAETEEGELVELAQKGDEVTEELLKKIIEAGIKEIDVFEKDKVVTYQILPKEPIKYKR
RLLSLKKAALNYPGWLSAAAFEETAWVLTAAAIEGKVDPLIGLKENVIVGQLIPAGTGLDVFAGIQVEET
PRAAVEEELA

>Tmaritima MSB8]
MPMSSFKRKIKAIQIKIASPEVIRSWSGGEVKKPETINYRTFKPERDGLFCERIFGPVKDYECACGKYKG
KKYEGTVCERCGVRVESREARRKRMGHIELAAPAVHIWYLESIPSVLGTLLNMSTSDLENIIYYGSRRVI
ERAFIVTDPKDTPFSQGDVIYETEYRIYRKKWDFDVEQAFVVKNPKSPVLSDIDGEVTLKTEKSITGREI
TWIIVKNITRATHTVLPGMILVVKDGQEVEKGQDLTKEMTIDPVYAPFDGHVEIDELSNTITLKPLTTSK
DQPVVFTIPYGAKILVSNGQKVKKGDQITTSTSLPAVKASISGTVRFGSNLNIRALEDGNFEVLSTGEVY
VEQVIEERKYPVFEGALVYVNNGDQVKKGDHLADRFLFEEEYLSATEYKIFESHYPTMFDVEERTENDRP
IVVITDIDPEVSKETGLKVGDIVTENEYEAYLQIYPEKIVADAGAQAIKKLLQNLDLEALQAEIEAELKK
LPSSSSKAIKLRRRLKMVKDFLKSGNKPEWMVLEVVPVIPPDLRPMIQIEGGRFATTDLNELYRRLINRN
NRLKKLLELGAPEIILRNEKRMLQEAVDALIHNGSDSEGKRSRRAVLKDRNGRPLKSLTDLLKGKKGRFR
RNLLGKRVDYSGRAVIVVGPNLKIHQCGIPKKMAMELFKPFVLAKLLGEGSSSKTMRKVKKAIIEKEMPE
AWEVLEEVIKGSVVLLNRAPTLHRMSIQAFEPKLVEGNAIQLHPVVCPPFNADFDGDQMAVHVPLSAAAQ
AEARFLMLSRYNIISPAHGKPISLPTQDIIIGSYYLTTVGKEFDSLKEEDVKWKFSSPEEAMLAYHLGFI
KLHTPILIKVAVNGEEKRIKTTLGRVIFNGILPEDLRDYNRIFDKKQINALVYETFKRHGIDRAADLLDD
IKDIGFHYATVSGLTLSLKDLKIPPERDEILRKTWEKVRIIEENYEKGFLTEEQRKSEIIRLWMSVTEEI
TKLTSKTLAEDPFNPIYMMVNSGARGNIDQVKQLAGIRGLMIKAYDPRSREIKSKIFKGQAIHEALTFDY
PVDKNLREGVDILQFFISTYGARKGQVDTAMNTSFAGYLTRRLVDVAQSVTVAEPDCGTHEGIRAMDLIK
EGTVVEKMNEFLFGRVLARDVLDPETKEVLKNPETGKEYTRNTMLTDDDANFLASYKKMVDVVRYEEIDI
TELSLPNMYAEIAEPVGEYEEGTELTWDVIKAAKNEGKYRIKVKVYPVVGTVYAEEEPLYDKKGERQLLV
YQEVINEIVAKMLEENGIEKVSVRPDIIVRSPLTCESEYGVCAACYGMDLSNHKIVNVGEAVGVVAAQSI
GEPGTQLTMRTFHVGGVMGASDIVSGLTTVEKTFEPYAFLREEKSGGKKEIRKYYGSEAILCEVDGFVKD
IATDESGRTVIYIEDYAGNIHAYKVPKRAKVRVEKGQKVLRGETLTSGAIVWWKLLELESEKGVMTAMNL
LKIIKNAYVQQGVSIHDKHFEIIFKQMLSMATIVDPGDSDYLPDQLVPLVDIKRFNREILEGNAKVEENR
KWVIGKTLAKRIITETEEGELVELAQKGDEVTEELLKKIIEAGIKEIDVFEKDKVVTYQILPKEPIKYKR
RLLSLKKAALNYPGWLSAAAFEETAWVLTAAAIEGKVDPLIGLKENVIVGQLIPAGTGLDVFAGIQVEET
PRAAVEEELA

>Tlettingae TMO]
MAISTFKRKIASVRVSVASPEIIRAWSSGEVKKPETINYRSFKPERDGLFCEKIFGPTKDYECACGKYKG
KKYEGTVCERCGVRVESKEARRKKMGHIELAAPVVHVWYLKSSPSILSTLLNIPARDLENIVYHGSRRII
ERSYIITDSKKTQFAAGDVLYETEYEVYKKVLDFDAEIAVTVKNPKSPVVSDIDGEVSIKSEQTNTGREI
IWITVKDSKKIPIQLQPGMILLSKNGQEVKEGTILVPEKQIAPFYAPFDGTVEIDEIASTLTIKPLTTSK
EQPVTVTIPYCVRVLVKNGSKVKAADELLSGGTIPAITSPASGKVVFGKELNVRPLEDDTYEVLSAGMLY
VEQLIQEKRYPIFEGSLPYVNDGDKVKAGDYLADRFLFEDEVLSAHEYKIFEDYYPQQFTVEAEVENDRP
IVAVTEIDDELSKETGLSVGSIITESEYEAYKELYPGKIEAHYGAAAVKKLLEKIDLEKLKAQIESELSQ
LPRSSGKALKLLKRLKIVKNLIKSGTKPEWMVLEAVPVIPPELRPMIQIDGGRFATTDLNDLYRRVINRN
NRLRRLLDLNAPDIIVRNEKRMLQESVDSLIYNGRIGKAVADRNGRALKSLTDLVKGKKGRFRRNLLGKR
VDYSGRAVIVVGPDLKIHQCGLPKKMAMELFRPFVLAQLLKEGGESSKTARKMKKAIIEKEMPEAWDILE
EVIKGHPVLLNRAPTLHRMSIQAFEPKLIEGNAIQLHPLVCPPFNADFDGDQMAVHVPLSAAAQAEAKYL
MLSRYNIISPAHGKPISMPGKDIIVGVYYLTAIGKDFDDVKTEEIRYRFGSTEEAILAYSLGYVDLHTPV
LAKVKVSDQEKIVKTTVGRIIFNEIILPDLRDYTRVFGKKEIKNLIYDTFKRHGIDATADLLDDMKDLGF
HYATVSGLTISLKDLIVSPKKDEIIRGAEQRVEQVEEEYRRGFLTFDERYREIIKIWNKATEDVQFVTQQ
ALGENPFNPIFMMVNSGARGNIDQVKQLAGMRGLMADPSGKTIEIPIISNFREGLTSMEFFISTHGARKG
AADTALRTSSAGYLTRRLVDVAQSIVITTTDCGTHEGLKAVELISDDLTVQKLKDFLFGRVLSRDVVDPL
TGEVIKNPVTGREYVRNAMLSDEDAEFLAEYVVSVPVSVEQVLDLQGLQLPHCYAEVCEEIRTVDGVYYE
EGTELNWDVVRNAKNAGKKQLKIKMYPVVGTISEQVIKDKKGEKELVVLREEIDELTAKILEENGVSQIK
VRPNIYVRSVLTCEAEKGVCAMCYGMDLSNHKVVNVGEAVGIIAAQSIGEPGTQLTMRTFHTGGIATTAD
ITQGLPRAEELFEARKKLKEPEGIFSTETGFVKDIKEVEGRQKIYIEDYSGGIHEYEVPEKTKVKVRIGQ
KVLPGTPLTTGAIRLRKLMDTLGVEATAMYLLKETQKVYVEQGVEIHNKHFEIIIKQMLGRVEIVDPGDT
DFLPGQLMTISEAEKINEKILRENANAQSNRNFVLGKILAKKVVAKVSDEVEEIASEGTEVTEEILEKAV
ESGVKEICIYDEGKQITYQIAPKEPMRYRRRLLRITKASLEQKGWLSAASFQQTPQVLTEAAVEGSIDLL
EGLKENVIVGQLVPAGTGLETFANIQIEETPRAAEAEKMA

>Marinitoga piezophila KA3 gi|214040202|gb|EEB80852.1| DNA-directed RNA polymerase, beta' subunit [Marinitoga piezophila KA3]
MSSFKRKIKAIQIKIASPEVIRSWSGGEVKKPETINYRTFKPERDGLFCERIFGPVKDYECACGKYKGKK
YEGTVCERCGVRVESREARRKRMGHIELAAPAVHIWYLESIPSVLGTLLNMSTSDLENIIYYGSRRVIER
AFIVTDPKDTPFSQGDVIYETEYRIYRKKWDFEVEQAFVVKNPKSPVLSDIDGEVTLKTEKSITGREITW
IIVKNITRATHTVLPGMILVVKDGQEVEKGQDLTKEMTIDPVYAPFDGHVEIDELSNTITLKPLTTSKDQ
PVVFTAPYGAKILVSNGQKVKKGDQITTSTSLPSVKSSISGTVRFGSNLNIRALEDGNFEVLSTGEVYVE
QVIEERKYPVFEGALVYVNNGDQVKKGDHLADRFLFEEEYLSATEYKIFESHYPTMFDVEERTENDRPIV
VITDIDPEVSKETGLKVGDIVTENEYEAYLQIYPEKIVADAGAQAIKKLLQNLDLEALQAEIEAELKKLP
SSSSKAIKLRRRLKMVKDFLKSGNKPEWMVLEVVPVIPPDLRPMIQIEGGRFATTDLNELYRRLINRNNR
LKKLLELGAPEIILRNEKRMLQEAVDALIHNGSDSEGKRSRRAVLKDRNGRPLKSLTDLLKGKKGRFRRN
LLGKRVDYSGRAVIVVGPHLKIHQCGIPKKMAMELFKPFVLAKLLGEGSSSKTMRKVKKAIIEKEMPEAW
EVLEEVIKGSVVLLNRAPTLHRMSIQAFEPKLVEGNAIQLHPVVCPPFNADFDGDQMAVHVPLSAAAQAE
ARFLMLSRYNIISPAHGKPISLPTQDIIIGSYYLTTVSKEFDSLKEEDVKWKFSSPEEAMLAYHLGFIKL
HTPILIKVVINGEEKRIKTTLGRVIFNSILPEDLRDYNRIFDKKQINTLVYETFKRHGIDRAADLLDDIK
DIGFHYATVSGLTLSLKDLKIPPERDEILRKTWEKVRIIEENYEKGFLTEEQRKSEIIRLWMSVTEEITK
LTSRTLAEDPFNPIYMMVNSGARGNIDQVKQLAGIRGLMIKAYDPRSREIKSKIFKGQAIHEALTFDYPV
DKNLREGVDILQFFISTYGARKGQVDTAMNTSFAGYLTRRLVDVAQSVTVAEPDCGTHEGIRAMDLIKEG
TVVEKMNEFLFGRVLAKDVLDPETKEVLKNPETGKEYTRNTMLTDDDANFLASYKKMVDVVRYEEIDITE
LSLPNMYAEIAEPVGEYEEGTELTWDVVKAAKNEGKYRIKVKVYPVVGTVYAEEEPLYDKKGERQLLVYQ
EVINEIVAKMLEENGIEKVPVRPDIIVRSPLTCESEYGVCAACYGMDLSNHKIVNVGESVGIVAAQSIGE
PGTQLTMRTFHVGGVMGASDIVSGLTTVEKTFEPYAFLREEKSGGKKEIRKYYGSESILCEVDGFVKDIA
TDESGRTVIYVEDYAGNIHAYKVPKRAKVRVEKGQKVLRGETLTSGAIVWWKLLELESEKGVMTAMNLLK
IIKNAYVQQGVSIHDKHFEIIFKQMLSMATIVDPGDSDYLPDQLVPLVDIKRFNREILEGNAKVEENRKW
VIGKTLAKRIIAETEEGELVELAQKGDEVTEELLKKIIEAGIKEIDVFEKDKVVTYQILPKEPIKYKRRL
LSLKKAALNYPGWLSAAAFEETAWVLTAAAIEGKVDPLIGLKENVIVGQLIPSGTGLDVFAGIQVEETPR
AAVEEELA



>Thermmelanesiensis BI429]
MMGSTFKRKISKVTVKVASPEVIRSWSSGEVKKPETINYRTFKPEKDGLFCEKIFGPTKDYECACGKYKG
KKYEGTVCERCGVRVESKEARRKRMGHIDLFAPVVHVWYLKSSPSILSSLLGIQAKELENVIYYGGKRII
EKILIVTNPKDTDFIKGSLLYQTEYEIYNQKLDFEVMPGVIIKSPVAPVISSISGEVKIRHEKTHTDREI
TWVDVRKISRAEHRVYNGMVLNVKNGDYVNQGDEIVSEMQIDPIYAPFDGTVEIDEISNTITIKPLTTSK
DMPVTFSLPYGVKPVVPNNSKVKKGDQLTNGTVLPAVIASVSGNISFGKELNVRPLEDGKYEVLTSGSVY
VENVVEEKHYPLFEGAFVYVKDGDEISEGQTIADRFLFEDEYLTLDEYKIFEQHYPAMFTAESEVENDRP
IVVITEIDDEVSVETGLKIGDIITDHQYSAYRTLYNDKIEADSGASAIKKLLQKLDLEKLKAEIESELKK
VSKSSGRAKKLLRRLKIVKDLLKSETKPEWMILEAIPVVPPDIRPMIQVEGGRFATTDLNDLYRRVINRN
NRLKKLYEMNSPEIIIKNEKRMLQEAVDSLIYNGRMGKAVTDRNGRALKSLTDLLKGKKGRFRRNLLGKR
VDYSGRAVIVVGPHLKIHECGLPKKMAMELFKPFVLAELLNKDDETSKTARKMKKAIIEKEMPQAYEVLE
EIIKGHPVLLNRAPTLHRMSLQAFEPKLIEGNAIQLHPLVCPPFNADFDGDQMAVHVPLSAAAQAEAKFL
MLSRYNIISPAHGKPISMPGKDIVAGVYYLTMVGKDYDKVQKENIKWKFSSIDEAELAYEFGHIRLHDPI
LVKVDDRVIKTTYGRLVFANIVPREFRDYNKTYGKGAIKDLVYKTFKKYGVDRTADLLDDIKDLGFHYAT
ISGLTVSITDFYISPERRRIIDEAKKKISEVEELFALGFLSDEERYRETIKIWADATEKVQDATFEYIGK
DPFNPVYIMVDSGARGNKDQLKQLAGMRGLMADPSGRTIEIPIISNFREGLSVLEFFISTHGARKGSADT
ALRTSSAGYLTRRLVDVAQSVVITTTDCGTENGVRATVLKSSDGLTVEKLEDFLFGRVLAKDVYDPKTNS
VLVNPENGKEYTRDTMIDDDDAKFLGNYSVRIPVSRELEINLTNPELPENYCELITDFIYDGVHYDEGTE
VNWDIIRKAKNSGLEKLTVKEYPIVGKVSVETVVSQKDIKQLVVDEELIMPTTAKILEGHNVESVQVRPE
IIVRSVLTCEAEHGVCSKCYGMDLSNHKIIGVGEAVGVVAAQSIGEPGTQLTMRTFHTGGIATTADITQG
LPRAEELFEARKKLKEPEGIFSRVKGYVKDIVEDETGKKKVYIEDEAGDIHEYDIPTKVKVSVNKGQKIL
PGQSLSTGAIRPRKILETLDVDTTALYLLKEIKKVYVEQGVDIHDKHFEIIIKQMLDKVEVIDPGDTDYL
PGDLLRLQMVKRINKQILEENVHVETNRKRVIGKILHQHLIAEDENGEIVEIAPEGVEVTEEILEKAIKS
GIKEIIVKNGDGEIVTYQILPKEPIKYRRRLLRITKASLERVGWLSAASFQQTPQVLTEAAIEGSVDHLL
GLKENVIVGQLIPAGTGLDMFANIQIEETPRLAQKEKMA

>Fervidonodosum Rt17-B1]
MSSSFKRKIASVNVRVASPEVIRNWSNGEVKKAETINYRTFKPERDGLFCERIFGPVKDYECACGKYSGK
KYEGTVCEKCGVKVESKDARRRRFGHIELAAPVTHVWYLKNSPSVIATLLDMTVKDIETIVYFGSRRVNE
RVVIVTDPKNTPFIKGSILNQTEYEIYAQKWDFEVSPAYIVKEPRSPLVSDIDGEVHIKHEKTHTDRELY
WIVVKNISRTELKVYTGMVLNFKDNDQVNQGDEIVSEKRVEAIFAPFDGTVEVDEISETITINPLPTSKN
NPITFSLPYGVRALVKNNEKVKKGQQLTTETILNSIVAPVSGTIRYSKQLNLRPLENGLYEVLTNGVIYI
ENVQNIKQYPVFEGAPIQVEDGQMVKAGDILADRFLFEEEKLTIEEYKLFSEYYPGMFVVEEQIENDKPI
MVITDIDPSVSEETGIKKGQVITQQDYEAYSRIYPGKIEAETGAMAIKKLLEKIDLEVMKAEIEAELKKI
PKSSVRAKKLLKKMKIVKDLIDSQTKPEWMVLEALPVVPPEIRPMIQIDGGRFATTDLNDLYRRVIMRNN
RLKKLLEMNAPEVIVRNEKRMLQEAVDNLIFNGKIGKAYVDRNGRQLKSLTDLIRGKKGRFRRNLLGKRV
DYSGRAVIVVGPHLKIHECGLPKKMALELFEPFVIAELSKEENTEAPQTKVKKYRKELQREDPKAWEKLE
KVIQGRVVLLNRAPTLHRMSIQAFEPKLIEGNAIQLHPLVCPPFNADFDGDQMAVHLPLSPAAQAEARLL
MLSRYNIISPAHGKPISMPGKDIVAGVYYLTMVDKNYDKIEPENIKWKFANPEEAELAYEFGFIKLHEPI
IIKINDKAIKTTFGRVIFNSILPEELRDYNKTFGKNGIKDVVYKTFKTHGIDRTADLLDSIKDLGFHYAT
ISGLTISLKDFMISPKKNEIITNAMKKIEYIEKLYDDGLLSDEEKYKETIKIWTETTNLVQEETYRYLGE
NPFNPVYIMVDSGARGNKDQLKQLSGMRGLMADPSGRTIEIPIISNFREGLSVLEFFISTHGARKGSADT
ALRTSSAGYLTRRLVDVVQSVVVTEPDCGTHEGVRATLLKSSDNFVVEKIEDFIFGRVLAKDIYEPGTGN
ILVNPNTNKSYTRDTVILDEDAKFLSNYKKRVNVVEESILDLSVGNIPEVYAELAEDIDTPSGLIPSETE
IDWDVVRKLRDAGIKNVKIKLYPIVGSVISEEIVWDKDRKKQIAVEEEQVDVALAKLLEENNIDSVYVRP
EIYVRSVLTCESEHGVCAKCYGLDLSNHKVVTVGESVGIIAAQSIGEPGTQLTMRTFHTGGIATTADITQ
GLPRVEELFEARKKTKDPEGIFSKVKGTVVDISNDEPKKIYIQDELGGIHEYEVPSRVRVNVTVGQKVLP
GQSLTSGSLKVRKILEELGPEETATYLLKEIKRVYVQQGVDIHDKHFELIIRQMLNKAEVIDSGDTEFLP
GDLVPISLLNKVNREIMEGNAKVEMNRKKIIGRELAKHIIVKNEDGEIVELAAEGEEVTEELLEKLIEYG
IKEVVIMNHDKEKEVYQILPKETVKYRRRLLRITQASLEYEGWLSAASFQQTQQVLTDAAIKGAVDYLKG
LKENVIVGQLIPAGTGFDIFSSVQYEETPRLAKEEKEKFA

>Kosmotoga
MAISTFNRKISTVQIKIASPERIRSWSSGEVKKPETINYRTFKPERDGLFCEKIFGPTKDYECACGKYKG
KKYEGTICERCGVRVESKEARRRRIGHIELAAPVVHVWYLKSAPSILASLLNIPSKDLENIIYYGSKRVI
EKLYVVTDPKGTDFFPGQTLYQTEYDIYSKKWDFDVEQGYKIRSPRGPVIAEIDGKVKIENGTGNTEREL
NWIIIEGENGITKKYPIFEGGLIYVQDGDEVRQGDTLADRFLFEDEVLSEKEFKIFEEYYPGKFESETDT
ESDRPIVIVTKIDEDVSKETGLKVGDIIIENEYDAYKEIYPGKIECDYGALAIQKLLRSLDLEELKIQIE
HELKGIPKSSARALKLLRRLKFVKDFLKSGNKPEWIVLEALPVIPPELRPMIQIEGGRFATTDLNDLYRR
VINRNNRLAKLLSIGAPDIIVRNEKRMLQEAVDSLIYNGRVGKAVTDKSGRPLKSLTDLVKGKKGRFRRN
LLGKRVDYSGRAVIVVGPDLKIHECGIPKRMAMELFKPFVLGKLLHGSESSKTARKLKKTIIEKEMPEAW
EVLEDVIKGHPVLLNRAPTLHRISIQAFIPRLVEGNAIQLHPLVCAPFNADFDGDQMAVHVPLSAAAQAE
AKFLMLSRYNVISPANGKPISMPGKDIIVGVYYLTTVDHEYKVFEEKLNKYQEELKSQGIDGVELRRRVR
EKALEKINWKFSSEAEALLAYDIGIIKLHEPILVKLDENKGDLTLTTVGRIIFNAILPEDLKDYSTTFGK
KAIKNLIYRCFQEYGIDRTADLLDDMMRLGFHYATISGLTISIRDIVIYPEKDKIIEEARKKVDKIEDLY
RKGFLNELDRSQEIIKIWEKTTEELMRKTFDEFKKYPFNPVFMMVDSGARGNIDQLKQLAGMRGLMADPS
GKTIEVPIISNFRDGLTELEFFTSTHGARKGSADTALRTSFAGYLTRRLVDVAQGVTITTPDCGTSNGIE
AFEMMADDVTIEKLEDFIFGRVLAEDVIDPETNEVLKNPVSGKEYIRDTMIRDEDAKFVASFRKTIPVKK
TEKVNLNEVGHFGYYAELAEDVEIGDKEFKAGTQLTSDILHELKTLEVGEVMLDIYPAVGKVYVGPKFRD
KNGTVLVKYQEKIDVVTAKKLVDNGFTSVEVRPVIKIRSVLTCDADHGVCAMCYGMDLSNHEIVNVGEAV
GIVAAQSIGEPGTQLTMRTFHTGGIATGADITRGLPRAEELFEARKKLKDPEALFAEEEGIVKDIATDEK
GRKKIYIETLEGKIKEHDLSTVIKPRVEVGDKVLKGESLTTGTIRPRKLMEKLGVIPTAMYLLMETKRVY
AEQGVEIHDKHFELIIRQMLSMVEVVDPGSTDYLPGDLLSLQDVKKINREILEDNKKVEENREYVIGRRL
ARRILDEDEEGNVTKIAVEGEPITEELMNKIIETGIKEITIYDVTEDEYQKLLEEIDPELVIPQKTIQIN
PKETIKYRRRLLRITKASLESHGWLSAASFQQTPQVLTEASVEGKVDYLLGLKENVIVGQLIPAGTGLDM
YANIQIEEAREVTEEAKDVG

>Pmobilis SJ95]
MANVSSFQRKIAKIKIGIASPQSILEASNGEVKKPETLNHRTGKPEKDGLFCEKIFGPVKDYECACGKYK
GKKYEGTVCERCGVKVESKEARRRKIGHIELATPISHIWYLKSSPSILSIILNIGVKDLENIIYYGSKRV
IERAYLTLPGPENENLGYLPGEILYQREYEIYDEYLDLRVEPAVKIVSVKGMPVADIDGKVEIKSELTHT
ERELNWIIIRDDTGVERKYPVFEGSSIMVENGQEVEKGTPLADRFLFEEDYLTQKEYSLFLEYYPGSIEV
ERDIERDTPIVVITDIDKRFAKRIDKKIGDILLEDEARAYEEVMKVLNSKIKEERENVIDKELVSEIEFP
EKKFEKGTKITQEVLNELQEFGVKDLVAKEEDGTEKIFQINRYEKFEYGYGAEAIQKLLTKIDLEVLKAR
LESELEKLDRKSQKSVKILRRLKLVKDFIKSGNQPEWLITNIIPVIPPDLRPLIQIDGGRFAATDLNDLY
RKVINRNNRLRKLLEMEAPEIIVRNEKRILQQAVDSLFYNGRVGKPMTDRNRRPLRSLTDLLKGKKGRFR
RNLLGKRVDYSGRAVIAVGPDLKIHECGLPKKMALELFKPFVLAELLRDSNVASKSARKFKKTIIEKEMP
EAWEVLEEVIKGHPVLLNRAPTLHRVSIQAFIPKLIEGNAIRLHPLVCPPFNADFDGDQMAIHIPLSNIA
QAESKFLMLSRYNIISPANGKPLSMPGKDIIAGAYYLTMHEDEKFKNLKVPTKVSELGKNGYVKHIFSED
LEATYAYEYLKIVDSDIYLQDGKLIWKKSDLPLHEPVAFRYKDGSILKTTIGKIIFNEEVPEDLRDYTQK
MDKKNLKELIFNTFEKHGIDRTADLLDSIKDFGFHYATLSGLTISIRDVLVSPKREELIEESKGEVLRIE
SLYEEGYLTDNERYKEIIKIWESATAKVTEETAKTYRKYTFNPIWMMIESGARGNIDQLKQLAGMRGLMA
DPSGKIIEVPITSNFKNGLSELEFFTSTHGSRKGSADTALRTSTAGYLTRRLVDVAQSITITEEDCGTDK
GIEARELWADDSKIENLSDFLFGRVLAKDVLDPETKEVIFNPQADKKYERGIILKEKDAQFLANYVKEIP
VSKEKTIKIEDMPKDSYLESLEDVQVEGKVLIKKGEEITEEAIEEAFLHGIQKLDVKEYTAVDYVYSGED
LKVEIDGKTVTLLKYQERIDLKVSKVLEKHGIKTVTVRPSIFIRSPLTCESENGLCAKCYGMDLSNYKLV
NRGEAVGIIAAQSIGEPGTQLTMRTFHTGGIATTSDITQGLPRAEELFEARKKTKGPEGEFSKTKGIVRA
IERDTENKRGRRLKIIIENSDGELESYEADYRTKAVVEEGDKVLAGQRLTTGNIKPRNILKELGVGPLAN
YLLSEIKKIYAEQGVDIHDKHFEIIIRQMINKVEIIDGGDTDFMPGDLVSYGKVQKINEEILEENSYITE
NRELVVGKKLAKRVIIPAEDEEEEEDKIFEQGTEITEEILNQIIETNIKEIEVYEEYKEITTEEGKTHLV
GTSKKYLINPKDTIKYERRLLRITKASLEREGWLSAASFQQTVQILTEAAIEGKVDRLKGLKENVIVGQP
IPAGTGLKLYADQNYEVVQPEKEAEAAQEKSVG

>Tnaphthophila RKU-10]
MPMSSFKRKIKAIQIKIASPEVIRSWSGGEVKKPETINYRTFKPERDGLFCERIFGPVKDYECACGKYKG
KKYEGTVCERCGVRVESREARRKRMGHIELAAPAVHIWYLESIPSVLGTLLNMSTSDLENIIYYGSRRVI
ERAFIVTDPKDTPFSQGDVIYETEYRIYRKKWDFEVEQAFVVKNPKSPVLSDIDGEVTLKTEKSITGREI
TWIIVKNITRATHTVLPGMILIVKDGQEVEKGQDLTKEMTIDPVYAPFDGHVEIDELSNTITLKPLTTSK
DQPVVFTAPYGAKILVSNGQKVKKGDQITTSTSLPSVKSSISGTVRFGSNLNIRALEDGNFEVLSTGEVY
VEQVIEERKYPVFEGALVYVNNGDQVKKGDHLADRFLFEEEYLSATEYKIFESHYPTMFDVEERTENDRP
IVVITDIDPEVSKETGLKVGDIVTENEYEAYLQIYPEKIVADAGAQAIKKLLQNLDLEALQAEIEAELKK
LPSSSSKAIKLRRRLKMVKDFLKSGNKPEWMVLEVVPVIPPDLRPMIQIEGGRFATTDLNELYRRLINRN
NRLKKLLELGAPEIILRNEKRMLQEAVDALIHNGSDSEGKRSRRAVLKDRNGRPLKSLTDLLKGKKGRFR
RNLLGKRVDYSGRAVIVVGPHLKIHQCGIPKKMAMELFKPFVLAKLLGEGSSSKTMRKVKKAIIEKEMPE
AWEVLEEVIKGSVVLLNRAPTLHRMSIQAFEPKLVEGNAIQLHPVVCPPFNADFDGDQMAVHVPLSAAAQ
AEARFLMLSRYNIISPAHGKPISLPTQDIIIGSYYLTTVSKEFDSLREEDVKWKFSSPEEAMLAYHLGFI
KLHTPILIKVAVNGEEKRIKTTLGRVIFNSILPEDLRDYNRIFDKKQINTLVYETFKRHGIDRAADLLDD
IKDIGFHYATVSGLTLSLKDLKVPPERDEILRKTWEKVRIIEENYEKGFLTEEQRKSEIIRLWMSVTEEI
TKLTSRTLAEDPFNPIYMMVNSGARGNIDQVKQLAGIRGLMIKAYDPRSREIKSKIFKGQAIHEALTFDY
PVDKNLREGVDILQFFISTYGARKGQVDTAMNTSFAGYLTRRLVDVAQSVTVAEPDCGTHDGIRAMDLIK
EGTVVEKMNEFLFGRVLARDVLDPETKEVLKNPETGKEYTRNTMLTDDDANFLASYKKMVDVVRYEEIDI
TELSLPNMYAEIAEPVGEYEEGTELTWDVVKAAKNEGKYRIKVKVYPVVGTVYAEEEPLYDKKGERQLLV
YQEVINEIVAKMLEENGIEKVPVRPDIIVRSPLTCESEYGVCAACYGMDLSNHKIVNVGESVGIVAAQSI
GEPGTQLTMRTFHVGGVMGASDIVSGLTTVEKTFEPYAFLREEKSGGKKEIKKYYGSEAILCEVDGFVRD
IATDESGRTVIYVEDYAGNIHAYKVPKRAKVRVEKGQKVLRGETLTSGAIVWWKLLELESEKGVMTAMNL
LKIIKNAYVQQGVSIHDKHFEIIFKQMLSMATIIDPGDSDYLPDQLVPLVDIKRFNREILEGNAKVEENR
KWVIGKTLAKRIITETEGGELVELAQKGDEVTEELLKKIIEAGIKEIDVFEKDKVVTYQILPKEPIKYKR
RLLSLKKAALNYPGWLSAAAFEETAWVLTAAAIEGKVDPLIGLKENVIVGQLIPSGTGLDVFAGIQVEET
PRAAVEEELA

>Tneapolitana DSM 4359]
MPMSSFKRKIKAIQIKIASPDVIRSWSGGEVKKPETINYRTFKPERDGLFCERIFGPVKDYECACGKYKG
KKYEGTVCERCGVRVESREARRKRMGHIELAAPAVHIWYLESIPSVLGTLLNMNVSDLENIIYYGSRRVI
ERAFIVTDPKDTPFAQGDIIYETEYRIYRKKWDFEVEQAFIVKNPRSPVLSDIDGEVILRTEKTVTGREI
TWIIVRNVNRAEHTVLPGMIITVKDGQEVEKGQDLTREMNVDPLYAPFDGHVEIDEISNTITVKPLTTSK
DQPVVFTVPYGARVLVSNGQKVKKGDQLTTSTTLPAVKASISGRVKFGSNLNVRALEDGNFEVLSSGNVY
IEQVIEERKYPVFEGALVYVNNGDQVKKGDHLADRFLFEEEYLSSTEYKIFESHYPTMFDVEERTENDRP
IVVITDIDPEVSKETGLKMGDIITENEYEAYLQIYPEKIVADAGAQAIKKLLQNLDLEELRAELEAELKK
LPASSSKAMKLRRRLKMVKDFIKSGNKPEWMVLEVVPVIPPDLRPMIQIEGGRFATTDLNELYRRLINRN
NRLRKLLELGAPEIILRNEKRMLQEAVDALIHNGSDSEGKRSRRAVLKDRNGRPLKSLTDLLKGKKGRFR
RNLLGKRVDYSGRAVIVVGPHLKIHQCGIPKKMAMELFKPFVLAKLLGEGSTSKTMRKVKKAIIEKEMPE
AWEVLEEVIKGSVVLLNRAPTLHRMSIQAFEPKLVEGNAIQLHPVVCPPFNADFDGDQMAVHVPLSAAAQ
AEARFLMLSRYNIISPAHGKPISLPTQDIIIGSYYLTTVGKDFDSLKEEDIRWRFSSPEEAMLAYHLGYI
KLHTPILIKVSIKGEEKRIKTTLGRVIFNSILPEDLRDYNRIFDKKQINALVYETFKRYGIDRAADLLDD
VKDLGFHYATVSGLTLSLKDLKIPPERDEILKRTWEKVRIIEENYERGFLTEEQRKSEIIRLWMNVTEEI
TELTSKTLAEDPFNPIYMMVNSGARGNIDQVKQLAGIRGLMIKAYDPRSREIKSKIFKGQAIHEALTFDY
PVDKNLREGVDILQFFISTYGARKGQVDTAMNTSFAGYLTRRLVDVAQSVTVTEPDCGTHEGIRAMDLIK
DGTVVEKMNEFLFGRVLASDVLDPETKEVLKNPETGKEYTRNTMLTDDDANFLASYKKMVDVVKYDEIDI
TELSLPNMYAEIAEPVGEYKEGTELTWDVVKAARNEGKYRIKVKMYPVVGTVYANEQPLYDKKGERELLV
YQEVINEVVAKLLEENGVEKVLVRPDIIVRSPLTCESEYGVCAACYGMDLSNHKIVNVGEAVGIVAAQSI
GEPGTQLTMRTFHVGGVMGASDIVSGLTTVEKTFEPYAFLREEKSGGKKEIRKYYGSEAVLCEVDGFVKD
IATDETGRTVIYIEDYAGGIHAYRIPKRAKVKVKKGQKVLRGDTLTTGAIVWWKLLELESEKGVLTAMNL
LKIIKNAYVQQGVSIHDKHFEIIFRQMLSMALVIDPGDSDYLPDQLVPLVDIKRTNREILEGNARVEENR
KWVIGKMLAKRVITETDDGELVELAQKGEEVTEELLKKFIEAGIKEIDVVEKDRVVTYQILPKEPIKYKR
RLLSLKKAALNYPGWLSAAAFEETAWVLTAAAIEGKVDPLIGLKENVIVGQLIPAGTGLDVFAGIQVEET
PRAAAEEKLA

>Thermo_africanus TCF52B]
MGSTFKREIAKVTVKVASPEVIRSWSSGEVKKPETINYRTFKPEKDGLFCEKIFGPTKDYECACGKYKGK
KYEGTVCERCGVRVESKEARRRRMGHIDLVAPVVHVWYLKSSPSILSSLLGIPAKELENVVYYGGKRIIE
KILIVTDPKNTDFIKGSQLYQTEYEIYSQKLDFEVVPGVIIKSPSTPVTSSISGEVKIRHEKTHTDREIT
WVDVRKISRAEHRLYTGMILNVKNGDKVNQGDEIVSEMQIDPIYAPFDGTVEIDEISESITVRPLSTSKD
IPVTFSLPYGVKPTVSNGAKVKKGDQLTNGTVLPAVVASVSGTISFGKDLNVRPREDGKYEVLKNGTLFV
ENVVEEKHYPLFEGALIYVEDGQEINEGDVIADRFLFEDEYLTIDEFKIFEEHYPAMFTAESEVENDRPI
VVITKIDDEVSVETGLKIGDIITDDQYWAYRVLYGEKIEADSGAAAIKKLLQNLDLEKLKAEIEAELKKV
SKSSGRAKKLLRRLKIVKDLLKSETKPEWMVLEAIPVVPPDIRPMIQVEGGRFATTDLNDLYRRVINRNN
RLKKLYEMNSPEIIIKNEKRMLQEAVDSLIYNGRMGKAVTDRNGRPLKSLTDLLKGKKGRFRRNLLGKRV
DYSGRAVIVVGPHLKIHECGLPKKMAMELFKPFVLAELLNKDDETSKTARKMKKAIIEKELPQAYEVLEE
IIKGHPVLLNRAPTLHRMSLQAFEPRLIEGNAIQLHPLVCPPFNADFDGDQMAVHVPLSAAAQAEAKFLM
LSRYNIISPAHGKPISMPGKDIVAGVYYLTMVDKNFDSVKEKDIKWKFSSIEEAGLAYEFGYIKLHDPIL
VKVDDKVIKTTYGRLIFASIVPDEFKDYNKTYGKGAIKDLVYNTFKKYGVDRTADLLDDIKDLGFHYATI
SGLTVSITDFYISPEREKIIEQAKAKVSEIEELFAEGFLSDEERYRETIKIWADATEKVQDATFEYIGKD
PFNPIYIMVDSGARGNKDQLKQLAGMRGLMADPSGRTIEIPIISNFREGLSVLEFFISTHGARKGSADTA
LRTSSAGYLTRRLVDVAQSVVVTTTDCGTHNGVRATVLKSSDGLTVEKLEDFLFGRVLAKDVFDPKTNNV
LVNPETGKQYTRDTIIDDDDAKFLGNYSVRIPVVTEGEIDLSSPELPESYCELAEDFVYNDVHYEVGTEV
NWDVVRKATSAGLSKLKVKIYPVVGKVSVETVLSSKDSKQLVVDEELIEVTTAKILEENNVESVQVRPEI
IVRSVLTCEAEHGVCSKCYGMDLSNHQIVGVGESVGVVAAQSIGEPGTQLTMRTFHTGGIATTADITQGL
PRAEELFEARKKLKEPEGVFSRVKGYVKDIVEDETGRKKVYIEDEAGDIHEYEIPIKVKVAVNKGQKVLP
GQSLSTGAIRPRKILETLDVDATALYLLKEIKKVYVEQGVDIHDKHFEIIIKQMLDKVEVVDPGDTDYLP
GDLVRLETVKRINKEILESNVQVDSNRKRVIGKELHHHLIAEDENGQIVEIAKEGEEVTEEILEKAIKLG
IKDLVVKNGEGEIVTYQILPKEPIKYRRRLLRITKASLERVGWLSAASFQQTPQVLTEAAIEGAEDLLLG
LKENVIVGQLIPAGTGLDMFANIQIEETPRFAQEKEKMA
